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OPENSEQ.org
GLPC - Anaerobic glycerol-3-phosphate dehydrogenase subunit C
UniProt: P0A996 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10393
Length: 396 (389)
Sequences: 2778
Seq/Len: 7.14
GLPC
Paralog alert: 0.64 [within 20: 0.02] - ratio of genomes with paralogs
Cluster includes: GLCF GLPC YKGE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
292_K 321_E 3.636 1.00
385_E 393_Q 3.617 1.00
181_D 389_T 3.595 1.00
184_K 392_A 3.409 1.00
201_C 244_C 3.112 1.00
162_Q 192_G 2.974 1.00
275_W 312_E 2.891 1.00
292_K 323_T 2.734 1.00
182_L 240_T 2.66 1.00
148_W 180_K 2.646 1.00
169_C 201_C 2.641 1.00
270_A 388_I 2.525 1.00
249_R 272_R 2.49 1.00
325_L 357_I 2.457 1.00
202_C 244_C 2.4 1.00
220_I 224_E 2.365 1.00
171_V 179_G 2.343 1.00
293_V 390_L 2.324 1.00
211_F 214_K 2.314 1.00
191_T 273_W 2.193 1.00
162_Q 235_I 2.189 1.00
297_T 311_L 2.167 1.00
311_L 324_V 2.162 1.00
71_K 74_D 2.122 1.00
294_V 325_L 2.12 1.00
97_H 100_L 2.078 1.00
169_C 244_C 2.045 1.00
268_E 276_R 2.038 1.00
238_I 273_W 2.024 1.00
366_V 390_L 2.018 1.00
169_C 202_C 1.926 1.00
177_Q 389_T 1.92 1.00
63_E 71_K 1.905 1.00
219_A 252_Y 1.87 1.00
182_L 270_A 1.862 1.00
165_F 240_T 1.837 1.00
186_L 238_I 1.79 1.00
163_V 273_W 1.775 1.00
189_M 395_L 1.766 1.00
161_D 191_T 1.761 1.00
241_S 369_C 1.748 1.00
216_R 220_I 1.709 1.00
163_V 193_V 1.699 1.00
204_V 243_T 1.691 1.00
183_I 193_V 1.686 1.00
292_K 363_D 1.675 1.00
239_A 245_T 1.672 1.00
32_K 37_D 1.672 1.00
178_L 389_T 1.666 1.00
200_K 221_T 1.632 1.00
297_T 324_V 1.63 1.00
291_L 363_D 1.627 1.00
185_V 391_L 1.62 1.00
58_N 300_H 1.606 1.00
163_V 238_I 1.575 1.00
231_G 262_G 1.561 1.00
293_V 320_L 1.549 1.00
350_G 354_F 1.546 1.00
81_A 212_T 1.543 1.00
222_N 252_Y 1.536 0.99
13_T 37_D 1.535 0.99
39_E 42_R 1.526 0.99
185_V 274_L 1.523 0.99
24_V 348_A 1.521 0.99
185_V 395_L 1.514 0.99
268_E 272_R 1.51 0.99
298_P 367_T 1.494 0.99
357_I 365_V 1.483 0.99
293_V 366_V 1.483 0.99
368_D 387_P 1.475 0.99
123_Q 126_D 1.434 0.99
314_L 366_V 1.434 0.99
145_F 183_I 1.396 0.99
182_L 186_L 1.395 0.99
312_E 315_R 1.386 0.99
276_R 280_E 1.386 0.99
385_E 389_T 1.367 0.99
343_Y 347_Q 1.362 0.98
302_E 307_T 1.321 0.98
236_P 268_E 1.314 0.98
275_W 313_L 1.313 0.98
385_E 390_L 1.312 0.98
188_A 392_A 1.306 0.98
357_I 376_I 1.301 0.98
295_Y 310_T 1.3 0.98
149_Y 183_I 1.297 0.98
274_L 313_L 1.295 0.98
9_C 15_C 1.294 0.98
225_S 228_E 1.281 0.98
189_M 277_K 1.278 0.97
168_G 241_S 1.273 0.97
204_V 208_A 1.272 0.97
207_I 212_T 1.266 0.97
162_Q 236_P 1.266 0.97
208_A 243_T 1.263 0.97
354_F 358_E 1.261 0.97
330_C 372_C 1.252 0.97
15_C 19_C 1.24 0.97
236_P 273_W 1.238 0.97
253_P 264_R 1.237 0.97
85_T 213_D 1.219 0.96
364_L 385_E 1.211 0.96
263_L 267_I 1.206 0.96
327_S 353_L 1.204 0.96
16_T 35_G 1.203 0.96
123_Q 127_A 1.198 0.96
313_L 391_L 1.195 0.96
279_D 312_E 1.191 0.96
158_Q 192_G 1.187 0.96
9_C 19_C 1.187 0.96
365_V 376_I 1.185 0.96
290_P 321_E 1.184 0.96
355_R 358_E 1.179 0.95
272_R 309_Y 1.178 0.95
181_D 392_A 1.178 0.95
18_A 65_A 1.172 0.95
266_H 276_R 1.16 0.95
224_E 228_E 1.158 0.95
122_R 126_D 1.155 0.95
188_A 395_L 1.155 0.95
10_I 16_T 1.153 0.95
332_I 337_G 1.145 0.94
315_R 321_E 1.143 0.94
207_I 247_A 1.136 0.94
230_V 266_H 1.135 0.94
306_W 309_Y 1.132 0.94
312_E 316_N 1.132 0.94
373_K 384_C 1.128 0.94
164_A 234_G 1.123 0.94
227_R 262_G 1.122 0.94
50_D 83_Y 1.122 0.94
224_E 227_R 1.111 0.93
183_I 187_N 1.11 0.93
229_A 234_G 1.108 0.93
306_W 310_T 1.101 0.93
74_D 254_E 1.1 0.93
187_N 193_V 1.096 0.92
315_R 322_L 1.091 0.92
178_L 181_D 1.091 0.92
297_T 310_T 1.091 0.92
350_G 375_Q 1.089 0.92
317_I 320_L 1.087 0.92
167_H 179_G 1.085 0.92
60_K 63_E 1.081 0.92
309_Y 312_E 1.081 0.92
268_E 273_W 1.081 0.92
278_L 313_L 1.08 0.92
308_L 315_R 1.079 0.92
272_R 306_W 1.078 0.92
12_C 15_C 1.076 0.92
164_A 229_A 1.074 0.91
32_K 38_G 1.074 0.91
185_V 392_A 1.074 0.91
18_A 39_E 1.073 0.91
294_V 360_S 1.072 0.91
165_F 182_L 1.07 0.91
9_C 12_C 1.07 0.91
91_R 341_E 1.068 0.91
22_S 30_G 1.062 0.91
291_L 364_L 1.056 0.90
185_V 388_I 1.055 0.90
227_R 231_G 1.052 0.90
243_T 300_H 1.052 0.90
79_A 83_Y 1.048 0.90
171_V 240_T 1.044 0.90
236_P 266_H 1.043 0.90
308_L 311_L 1.041 0.90
218_Q 221_T 1.039 0.90
288_P 320_L 1.038 0.89
271_T 368_D 1.031 0.89
354_F 380_T 1.026 0.89
299_C 329_C 1.02 0.88
307_T 310_T 1.02 0.88
191_T 277_K 1.02 0.88
12_C 19_C 1.019 0.88
271_T 387_P 1.019 0.88
40_R 43_L 1.015 0.88
16_T 32_K 1.009 0.88
122_R 125_L 1.006 0.87
63_E 73_G 1.003 0.87
83_Y 87_R 1.003 0.87
389_T 392_A 1.002 0.87
351_A 355_R 1.002 0.87
347_Q 379_S 1.002 0.87
292_K 361_G 1 0.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3kwlA10.79551000.47Contact Map0.537
3cf4A10.80051000.586Contact Map0.128
3c8yA10.767799.60.822Contact Map0.162
2h88B20.217299.20.856Contact Map0.454
3vr8B20.229899.20.856Contact Map0.408
2wdqB30.212199.20.857Contact Map0.482
1kf6B20.222299.20.86Contact Map0.353
2bs2B20.212199.10.865Contact Map0.448
1hfeL20.760198.10.901Contact Map0.128
3i9v920.343498.10.902Contact Map0.249
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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