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OPENSEQ.org

SURE - 5'/3'-nucleotidase SurE
UniProt: P0A840 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11817
Length: 253 (244)
Sequences: 1510
Seq/Len: 6.19

SURE
Paralog alert: 0.09 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
113_G 120_A 3.701 1.00
2_R 28_D 3.445 1.00
170_G 221_Y 3.229 1.00
174_T 223_S 3.035 1.00
123_V 160_V 3.006 1.00
172_R 221_Y 2.913 1.00
163_L 220_G 2.875 1.00
23_L 88_V 2.809 1.00
52_R 190_D 2.803 1.00
87_V 113_G 2.579 1.00
158_I 224_I 2.53 1.00
215_A 219_E 2.444 1.00
216_A 223_S 2.354 1.00
21_K 135_A 2.309 1.00
238_D 241_S 2.205 1.00
5_L 20_A 2.166 1.00
93_A 131_Y 2.153 1.00
187_P 195_T 2.137 1.00
188_Q 196_L 2.098 1.00
174_T 216_A 2.03 1.00
169_K 221_Y 2.027 1.00
123_V 138_T 2.016 1.00
134_A 160_V 1.938 1.00
121_L 158_I 1.897 1.00
55_T 58_N 1.856 1.00
86_I 142_L 1.855 1.00
97_L 217_V 1.812 1.00
11_V 60_D 1.8 1.00
49_S 64_Q 1.768 1.00
5_L 29_V 1.755 1.00
123_V 158_I 1.72 1.00
41_A 44_S 1.684 1.00
38_R 41_A 1.675 1.00
78_A 187_P 1.673 1.00
137_V 160_V 1.673 1.00
26_F 143_R 1.657 1.00
217_V 223_S 1.604 1.00
25_E 139_C 1.595 0.99
14_P 18_T 1.592 0.99
20_A 60_D 1.565 0.99
164_P 167_Q 1.508 0.99
88_V 123_V 1.478 0.99
175_R 212_T 1.475 0.99
139_C 143_R 1.473 0.99
53_T 79_L 1.467 0.99
6_S 89_S 1.46 0.99
97_L 100_D 1.432 0.99
20_A 31_V 1.432 0.99
158_I 222_V 1.428 0.99
3_I 86_I 1.427 0.99
13_A 93_A 1.417 0.99
18_T 22_A 1.405 0.98
136_A 165_L 1.393 0.98
154_R 233_A 1.381 0.98
14_P 93_A 1.367 0.98
89_S 109_A 1.365 0.98
145_L 149_P 1.362 0.98
22_A 25_E 1.36 0.98
137_V 222_V 1.357 0.98
141_I 158_I 1.347 0.98
103_Y 112_E 1.313 0.97
216_A 221_Y 1.304 0.97
137_V 168_I 1.298 0.97
230_D 234_H 1.282 0.97
35_D 38_R 1.282 0.97
111_M 229_V 1.271 0.96
150_L 156_L 1.254 0.96
191_P 198_W 1.241 0.96
22_A 135_A 1.24 0.96
175_R 211_G 1.234 0.96
114_R 155_I 1.233 0.96
6_S 109_A 1.231 0.96
20_A 24_R 1.23 0.96
2_R 30_Q 1.221 0.95
6_S 113_G 1.212 0.95
234_H 238_D 1.207 0.95
50_S 198_W 1.203 0.95
30_Q 61_I 1.196 0.95
46_T 70_D 1.191 0.94
238_D 242_D 1.191 0.94
189_Q 195_T 1.189 0.94
6_S 72_V 1.188 0.94
101_V 107_V 1.186 0.94
5_L 23_L 1.181 0.94
110_A 120_A 1.175 0.94
5_L 88_V 1.174 0.94
130_H 133_T 1.169 0.94
233_A 236_A 1.169 0.94
190_D 194_N 1.155 0.93
210_P 219_E 1.14 0.92
171_I 224_I 1.139 0.92
143_R 147_K 1.134 0.92
192_R 196_L 1.126 0.92
163_L 168_I 1.125 0.92
135_A 139_C 1.104 0.91
80_M 84_P 1.098 0.91
107_V 227_L 1.087 0.90
20_A 29_V 1.083 0.90
41_A 75_G 1.078 0.89
163_L 167_Q 1.077 0.89
43_N 112_E 1.074 0.89
169_K 220_G 1.072 0.89
23_L 26_F 1.068 0.89
42_S 108_A 1.061 0.88
228_H 233_A 1.049 0.88
102_I 111_M 1.033 0.87
43_N 108_A 1.033 0.87
211_G 215_A 1.028 0.86
155_I 227_L 1.024 0.86
144_A 148_E 1.023 0.86
151_R 154_R 1.018 0.86
51_L 64_Q 1.015 0.85
127_G 162_D 1.005 0.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2v4nA111000.026Contact Map0.696
3ty2A20.98021000.033Contact Map0.822
2phjA20.97231000.034Contact Map0.806
1j9jA20.95261000.05Contact Map0.761
1l5xA20.98021000.073Contact Map0.691
2e6cA40.92091000.078Contact Map0.739
3h4tA10.853845.40.955Contact Map0.659
1iirA10.83441.60.956Contact Map0.566
1rrvA20.91740.20.956Contact Map0.663
2yjnA10.865622.70.962Contact Map0.684

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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