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OPENSEQ.org
SELA - L-seryl-tRNA(Sec) selenium transferase
UniProt: P0A821 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10941
Length: 463 (456)
Sequences: 480
Seq/Len: 1.05
SELA
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
208_A 247_L 3.893 1.00
162_A 318_H 3.678 1.00
163_A 318_H 3.465 1.00
248_G 255_V 3.321 1.00
135_A 146_D 3.231 1.00
91_L 98_A 3.184 1.00
221_L 256_V 3.149 1.00
390_C 408_A 3.1 1.00
212_R 250_E 2.978 1.00
288_L 315_L 2.813 1.00
437_G 444_L 2.732 1.00
101_A 337_T 2.703 1.00
392_S 406_S 2.52 0.99
245_V 255_V 2.494 0.99
140_R 342_L 2.481 0.99
160_M 256_V 2.442 0.99
173_S 206_T 2.427 0.99
390_C 406_S 2.413 0.99
99_L 353_T 2.358 0.99
101_A 340_L 2.337 0.99
282_I 306_V 2.294 0.99
98_A 353_T 2.251 0.98
168_K 220_A 2.246 0.98
120_Y 436_I 2.216 0.98
15_I 44_L 2.188 0.98
108_V 329_M 2.176 0.98
131_D 321_K 2.161 0.98
120_Y 124_D 2.151 0.98
103_A 350_K 2.142 0.98
176_E 224_K 2.022 0.96
198_H 216_N 1.981 0.96
79_A 133_A 1.959 0.95
15_I 40_L 1.957 0.95
437_G 446_L 1.953 0.95
256_V 290_S 1.95 0.95
365_Q 369_Q 1.889 0.94
359_R 367_Q 1.888 0.94
138_L 147_A 1.883 0.94
274_K 280_E 1.815 0.92
99_L 114_S 1.809 0.92
207_H 237_K 1.779 0.91
107_A 336_A 1.76 0.90
18_L 40_L 1.747 0.90
309_K 313_A 1.746 0.90
392_S 447_D 1.743 0.90
288_L 311_M 1.719 0.89
134_L 147_A 1.718 0.89
171_V 178_V 1.713 0.89
160_M 290_S 1.712 0.89
188_D 319_P 1.695 0.88
248_G 253_V 1.653 0.86
192_Q 318_H 1.647 0.86
158_L 323_A 1.631 0.85
222_L 248_G 1.629 0.85
408_A 445_W 1.618 0.85
207_H 239_I 1.607 0.84
170_V 195_C 1.605 0.84
227_T 230_Y 1.605 0.84
287_S 308_K 1.591 0.83
451_L 454_E 1.59 0.83
409_L 448_L 1.584 0.83
131_D 189_V 1.576 0.83
308_K 311_M 1.56 0.82
372_Q 409_L 1.554 0.81
162_A 192_Q 1.547 0.81
46_E 71_R 1.538 0.80
406_S 447_D 1.518 0.79
222_L 253_V 1.503 0.78
33_H 37_V 1.502 0.78
422_E 425_A 1.486 0.77
169_E 216_N 1.482 0.77
148_C 321_K 1.476 0.76
91_L 393_Q 1.474 0.76
438_R 447_D 1.464 0.76
215_V 253_V 1.446 0.74
16_D 19_L 1.412 0.72
21_D 24_F 1.409 0.72
448_L 451_L 1.408 0.71
241_E 286_V 1.407 0.71
389_P 407_A 1.406 0.71
178_V 330_T 1.406 0.71
104_A 107_A 1.4 0.71
359_R 364_I 1.39 0.70
406_S 448_L 1.373 0.69
43_M 68_V 1.366 0.68
391_L 403_R 1.358 0.68
98_A 296_L 1.354 0.67
105_V 113_R 1.346 0.67
134_L 138_L 1.334 0.66
337_T 352_P 1.32 0.64
9_Y 51_I 1.313 0.64
9_Y 52_R 1.312 0.64
176_E 233_Q 1.299 0.62
169_E 219_T 1.29 0.62
104_A 336_A 1.289 0.62
435_V 458_L 1.285 0.61
422_E 442_G 1.276 0.60
91_L 398_S 1.274 0.60
428_W 444_L 1.27 0.60
37_V 41_R 1.263 0.59
176_E 279_Q 1.256 0.59
410_T 443_R 1.244 0.58
51_I 101_A 1.229 0.56
91_L 230_Y 1.222 0.55
221_L 248_G 1.219 0.55
223_M 256_V 1.218 0.55
138_L 306_V 1.211 0.54
189_V 323_A 1.208 0.54
188_D 191_R 1.202 0.54
188_D 202_T 1.19 0.52
170_V 221_L 1.186 0.52
12_L 44_L 1.183 0.52
135_A 316_Q 1.182 0.52
410_T 445_W 1.18 0.52
326_A 330_T 1.179 0.51
364_I 448_L 1.176 0.51
223_M 290_S 1.173 0.51
388_M 410_T 1.171 0.51
79_A 91_L 1.16 0.50
268_S 274_K 1.145 0.48
172_V 219_T 1.144 0.48
164_T 315_L 1.14 0.48
431_L 434_P 1.131 0.47
209_N 213_Q 1.131 0.47
105_V 109_A 1.131 0.47
392_S 408_A 1.128 0.47
100_Q 428_W 1.127 0.47
245_V 248_G 1.125 0.46
248_G 254_P 1.122 0.46
165_A 221_L 1.113 0.45
241_E 257_T 1.111 0.45
19_L 36_V 1.109 0.45
190_M 207_H 1.108 0.45
165_A 248_G 1.106 0.45
89_T 183_A 1.106 0.45
257_T 281_L 1.102 0.44
15_I 406_S 1.102 0.44
43_M 71_R 1.102 0.44
422_E 439_I 1.099 0.44
89_T 393_Q 1.097 0.44
160_M 221_L 1.096 0.44
134_L 331_L 1.089 0.43
347_L 351_L 1.086 0.43
160_M 315_L 1.083 0.42
139_C 147_A 1.075 0.42
102_E 113_R 1.073 0.42
304_I 334_L 1.072 0.41
189_V 192_Q 1.07 0.41
115_P 396_S 1.07 0.41
215_V 222_L 1.07 0.41
221_L 254_P 1.067 0.41
171_V 458_L 1.066 0.41
89_T 394_I 1.061 0.40
176_E 238_A 1.06 0.40
158_L 288_L 1.058 0.40
84_I 451_L 1.058 0.40
255_V 287_S 1.055 0.40
91_L 205_R 1.055 0.40
316_Q 330_T 1.052 0.40
117_T 122_L 1.051 0.40
147_A 170_V 1.05 0.39
165_A 255_V 1.05 0.39
148_C 396_S 1.046 0.39
233_Q 401_V 1.042 0.39
230_Y 371_L 1.039 0.39
189_V 202_T 1.037 0.38
276_P 327_D 1.037 0.38
31_Y 91_L 1.034 0.38
15_I 37_V 1.031 0.38
86_L 396_S 1.03 0.38
56_T 64_W 1.027 0.37
171_V 222_L 1.027 0.37
134_L 146_D 1.027 0.37
305_I 309_K 1.026 0.37
116_V 450_C 1.026 0.37
246_A 250_E 1.025 0.37
344_P 347_L 1.023 0.37
161_L 190_M 1.022 0.37
180_I 202_T 1.022 0.37
107_A 111_A 1.02 0.37
131_D 347_L 1.02 0.37
310_E 313_A 1.016 0.36
430_E 434_P 1.014 0.36
98_A 148_C 1.014 0.36
363_V 366_I 1.011 0.36
212_R 247_L 1.01 0.36
368_A 371_L 1.01 0.36
131_D 148_C 1.009 0.36
208_A 237_K 1.004 0.35
241_E 281_L 1.003 0.35
169_E 196_T 1.003 0.35
54_S 198_H 1.002 0.35
365_Q 389_P 1 0.35
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3w1hA50.96111000.628Contact Map0.725
3w1iA100.83151000.759Contact Map0.754
3madA20.866199.80.893Contact Map0.509
4lhdA20.842399.80.901Contact Map0.369
2oatA30.848899.70.907Contact Map0.511
3mc6A10.833799.70.909Contact Map0.428
2vi8A10.747399.70.909Contact Map0.594
2hufA20.725799.70.91Contact Map0.555
2bkwA10.701999.70.91Contact Map0.502
2yrrA20.682599.70.911Contact Map0.566
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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