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OPENSEQ.org

RNH - Ribonuclease HI
UniProt: P0A7Y4 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10860
Length: 155 (144)
Sequences: 1910
Seq/Len: 13.26

RNH
Paralog alert: 0.06 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
57_E 106_R 3.947 1.00
101_V 105_Q 3.851 1.00
86_K 108_D 3.737 1.00
72_Q 76_Q 3.71 1.00
76_Q 80_Q 3.546 1.00
66_I 119_E 3.54 1.00
54_V 57_E 3.242 1.00
7_I 55_A 3.034 1.00
126_G 131_E 2.921 1.00
14_L 138_R 2.78 1.00
52_A 74_V 2.569 1.00
34_T 132_R 2.521 1.00
14_L 142_M 2.296 1.00
14_L 141_A 2.295 1.00
46_R 102_D 2.063 1.00
64_E 115_Q 2.044 1.00
52_A 67_L 2.019 1.00
84_N 88_R 1.942 1.00
57_E 110_A 1.893 1.00
3_K 61_E 1.751 1.00
66_I 117_K 1.697 1.00
69_T 75_R 1.675 1.00
50_M 54_V 1.652 1.00
12_S 141_A 1.617 1.00
36_S 139_A 1.602 1.00
135_E 139_A 1.596 1.00
6_E 27_R 1.57 1.00
122_K 125_A 1.517 1.00
77_G 104_W 1.515 1.00
68_S 119_E 1.487 1.00
21_G 141_A 1.464 1.00
4_Q 66_I 1.459 1.00
138_R 142_M 1.457 1.00
24_A 55_A 1.437 1.00
22_Y 37_A 1.419 1.00
12_S 137_A 1.417 1.00
27_R 129_E 1.404 0.99
111_L 118_W 1.367 0.99
25_I 133_C 1.363 0.99
4_Q 64_E 1.34 0.99
9_T 51_A 1.321 0.99
27_R 32_E 1.311 0.99
24_A 35_F 1.29 0.99
110_A 113_Q 1.279 0.99
23_G 140_A 1.246 0.98
132_R 135_E 1.232 0.98
23_G 136_L 1.217 0.98
36_S 140_A 1.216 0.98
92_T 98_V 1.212 0.98
8_F 129_E 1.203 0.98
106_R 110_A 1.195 0.98
22_Y 39_Y 1.193 0.98
133_C 140_A 1.183 0.98
8_F 68_S 1.179 0.98
138_R 141_A 1.179 0.98
88_R 95_K 1.17 0.97
72_Q 75_R 1.165 0.97
75_R 79_T 1.153 0.97
53_I 106_R 1.147 0.97
84_N 87_K 1.134 0.97
21_G 137_A 1.129 0.97
6_E 68_S 1.127 0.97
49_L 73_Y 1.106 0.96
6_E 66_I 1.091 0.96
72_Q 120_W 1.065 0.95
22_Y 54_V 1.064 0.95
20_G 47_M 1.061 0.95
53_I 107_L 1.055 0.95
36_S 136_L 1.04 0.94
125_A 131_E 1.037 0.94
8_F 127_H 1.035 0.94
42_T 46_R 1.016 0.93
109_A 112_G 1.004 0.93
39_Y 46_R 1.003 0.93
128_P 132_R 1.003 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1jl1A111000.209Contact Map0.718
2e4lA111000.251Contact Map0.784
3h08A20.93551000.257Contact Map0.866
4ibnA10.99351000.283Contact Map0.724
1rilA111000.286Contact Map0.704
2lsnA10.93551000.301Contact Map0.584
2qkbA20.93551000.309Contact Map0.729
3qioA10.90971000.325Contact Map0.61
4mh8A10.97421000.332Contact Map
4hkqA10.97421000.339Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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