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OPENSEQ.org

RL7 - 50S ribosomal protein L7/L12
UniProt: P0A7K2 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10873
Length: 121 (121)
Sequences: 1427
Seq/Len: 11.79

RL7
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
76_A 107_L 3.309 1.00
108_K 112_E 3.118 1.00
13_A 30_K 3.067 1.00
111_L 116_A 2.905 1.00
60_K 117_E 2.84 1.00
60_K 119_E 2.774 1.00
106_A 110_A 2.752 1.00
82_K 86_D 2.72 1.00
7_Q 11_A 2.671 1.00
75_G 110_A 2.639 1.00
109_K 113_E 2.585 1.00
61_A 117_E 2.558 1.00
72_A 75_G 2.244 1.00
100_S 103_D 2.163 1.00
58_I 94_A 2.068 1.00
65_N 68_A 1.976 1.00
9_I 27_M 1.848 1.00
10_E 14_A 1.78 1.00
68_A 114_A 1.699 1.00
103_D 106_A 1.65 1.00
56_D 98_G 1.64 1.00
52_K 56_D 1.609 1.00
62_A 89_E 1.529 1.00
86_D 90_S 1.478 1.00
10_E 13_A 1.474 1.00
73_V 88_V 1.452 1.00
8_I 11_A 1.404 0.99
21_V 25_S 1.393 0.99
11_A 14_A 1.367 0.99
5_K 15_M 1.354 0.99
108_K 118_V 1.353 0.99
102_D 106_A 1.344 0.99
17_V 20_V 1.333 0.99
61_A 64_A 1.25 0.99
55_F 101_K 1.234 0.98
5_K 26_A 1.23 0.98
106_A 109_K 1.215 0.98
103_D 107_L 1.214 0.98
12_V 27_M 1.208 0.98
96_K 103_D 1.192 0.98
72_A 113_E 1.157 0.97
7_Q 10_E 1.148 0.97
25_S 28_E 1.135 0.97
105_E 109_K 1.12 0.96
99_V 120_V 1.112 0.96
51_E 101_K 1.103 0.96
12_V 31_F 1.096 0.96
6_D 26_A 1.095 0.96
96_K 107_L 1.092 0.96
76_A 110_A 1.088 0.96
66_K 88_V 1.059 0.95
4_T 7_Q 1.04 0.94
8_I 23_L 1.034 0.94
105_E 120_V 1.032 0.94
67_V 74_R 1.025 0.93
16_S 19_D 1.023 0.93
13_A 31_F 1.021 0.93
72_A 110_A 1.02 0.93
90_S 93_A 1.015 0.93
11_A 15_M 1.011 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4kix6111000.007Contact Map0.23
2zjq510.99171000.036Contact Map0.029
2j01L10.99171000.037Contact Map
1dd3A20.98351000.045Contact Map0.619
2ftcE20.98351000.08Contact Map0.07
1ctfA10.611699.90.319Contact Map0.603
4kbue10.809999.90.369Contact Map0.185
4kcze10.801799.90.374Contact Map0.213
1dd4C20.330698.70.721Contact Map0.398
1zavU60.247997.50.791Contact Map0.83

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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