May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org
PPK - Polyphosphate kinase
UniProt: P0A7B1 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11510
Length: 688 (677)
Sequences: 1192
Seq/Len: 1.76
PPK
Paralog alert: 0.05 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
356_L 441_I 5.953 1.00
502_Y 629_L 5.291 1.00
525_A 531_S 5.29 1.00
560_N 581_R 4 1.00
520_R 605_K 3.936 1.00
524_N 529_L 3.536 1.00
548_R 551_A 3.503 1.00
535_L 613_W 3.461 1.00
519_D 548_R 3.273 1.00
519_D 551_A 3.102 1.00
608_L 626_T 3.004 1.00
58_K 286_D 2.884 1.00
573_L 576_I 2.858 1.00
515_Y 548_R 2.799 1.00
522_I 548_R 2.724 1.00
455_I 626_T 2.708 1.00
453_A 481_T 2.46 1.00
558_P 581_R 2.399 1.00
511_R 619_D 2.367 1.00
628_L 637_V 2.365 1.00
532_G 560_N 2.364 1.00
324_F 474_L 2.322 1.00
596_Y 613_W 2.294 1.00
398_V 423_V 2.29 1.00
336_I 476_A 2.251 1.00
125_H 129_Q 2.234 0.99
343_L 474_L 2.225 0.99
116_S 119_Q 2.219 0.99
122_W 186_P 2.201 0.99
599_E 604_K 2.153 0.99
519_D 522_I 2.125 0.99
545_L 618_I 2.111 0.99
54_F 80_I 2.107 0.99
356_L 474_L 2.103 0.99
523_A 527_Q 2.07 0.99
331_N 359_Q 2.064 0.99
514_L 545_L 2.064 0.99
356_L 439_F 2.061 0.99
335_A 341_V 2.06 0.99
581_R 653_Y 2.055 0.99
606_V 638_L 2.04 0.99
336_I 474_L 2.037 0.99
513_L 517_M 2.031 0.99
655_D 659_S 2.015 0.99
519_D 523_A 2.009 0.99
475_T 480_I 1.992 0.99
438_L 484_V 1.984 0.99
587_D 672_R 1.966 0.98
26_A 90_E 1.963 0.98
455_I 608_L 1.961 0.98
362_F 388_H 1.958 0.98
520_R 600_N 1.953 0.98
528_G 531_S 1.935 0.98
357_L 439_F 1.918 0.98
506_S 510_S 1.916 0.98
525_A 528_G 1.901 0.98
337_R 450_V 1.889 0.98
147_V 293_R 1.888 0.98
324_F 341_V 1.881 0.98
183_V 202_I 1.864 0.98
221_N 269_P 1.863 0.98
6_L 576_I 1.848 0.97
162_I 218_D 1.835 0.97
23_Q 652_R 1.833 0.97
558_P 579_N 1.833 0.97
530_P 599_E 1.831 0.97
16_S 83_R 1.816 0.97
583_I 651_A 1.813 0.97
517_M 605_K 1.791 0.97
16_S 19_E 1.786 0.97
550_Y 577_S 1.775 0.96
90_E 93_G 1.765 0.96
532_G 558_P 1.761 0.96
521_E 600_N 1.755 0.96
50_Y 288_I 1.75 0.96
147_V 662_Y 1.741 0.96
101_E 104_R 1.718 0.95
37_R 313_N 1.678 0.95
541_V 568_S 1.656 0.94
342_L 473_L 1.641 0.94
537_L 613_W 1.629 0.93
504_M 513_L 1.624 0.93
524_N 599_E 1.609 0.93
7_Y 547_D 1.607 0.93
414_W 419_T 1.574 0.92
600_N 604_K 1.571 0.92
147_V 292_G 1.569 0.92
337_R 445_E 1.562 0.91
288_I 293_R 1.561 0.91
525_A 529_L 1.557 0.91
522_I 526_Q 1.556 0.91
609_S 625_A 1.554 0.91
534_T 641_I 1.551 0.91
111_N 201_N 1.547 0.91
339_R 632_R 1.541 0.91
671_V 676_A 1.538 0.91
522_I 559_V 1.525 0.90
463_K 467_L 1.524 0.90
445_E 452_Y 1.52 0.90
148_Q 662_Y 1.514 0.90
358_R 388_H 1.511 0.90
522_I 525_A 1.508 0.89
141_N 144_T 1.504 0.89
123_L 202_I 1.503 0.89
604_K 638_L 1.489 0.89
24_E 650_K 1.482 0.88
562_L 645_F 1.478 0.88
273_V 289_V 1.472 0.88
524_N 600_N 1.462 0.87
40_G 301_I 1.461 0.87
453_A 484_V 1.459 0.87
19_E 90_E 1.452 0.87
174_I 203_L 1.451 0.87
146_L 293_R 1.446 0.87
81_Q 85_L 1.445 0.87
535_L 561_L 1.439 0.86
518_V 533_I 1.438 0.86
560_N 645_F 1.436 0.86
109_L 198_L 1.428 0.86
511_R 515_Y 1.426 0.86
477_D 629_L 1.425 0.86
119_Q 195_P 1.424 0.85
103_A 108_F 1.412 0.85
554_S 578_D 1.41 0.85
511_R 542_D 1.402 0.84
147_V 289_V 1.401 0.84
101_E 105_N 1.397 0.84
596_Y 609_S 1.396 0.84
504_M 609_S 1.392 0.84
289_V 293_R 1.391 0.84
331_N 334_D 1.383 0.83
130_Y 444_K 1.382 0.83
368_A 442_S 1.379 0.83
228_T 263_V 1.372 0.82
57_L 76_L 1.371 0.82
529_L 601_G 1.37 0.82
128_K 209_D 1.367 0.82
644_L 673_A 1.367 0.82
534_T 645_F 1.363 0.82
593_D 644_L 1.359 0.82
147_V 288_I 1.355 0.81
6_L 547_D 1.355 0.81
34_E 588_R 1.352 0.81
377_A 381_R 1.352 0.81
42_Y 87_A 1.346 0.81
453_A 475_T 1.34 0.80
547_D 576_I 1.339 0.80
540_L 563_V 1.326 0.79
26_A 94_L 1.32 0.79
83_R 86_K 1.316 0.79
597_I 641_I 1.313 0.78
37_R 301_I 1.311 0.78
28_K 97_E 1.309 0.78
643_I 671_V 1.308 0.78
540_L 569_L 1.304 0.78
357_L 382_I 1.299 0.77
147_V 291_G 1.29 0.77
525_A 530_P 1.289 0.77
487_V 624_V 1.289 0.77
342_L 633_L 1.282 0.76
514_L 613_W 1.275 0.76
455_I 624_V 1.274 0.75
532_G 599_E 1.272 0.75
290_P 293_R 1.272 0.75
343_L 352_H 1.265 0.75
561_L 582_A 1.263 0.75
676_A 679_D 1.26 0.74
35_R 94_L 1.258 0.74
355_E 359_Q 1.257 0.74
471_Y 595_V 1.249 0.73
147_V 290_P 1.245 0.73
204_R 265_Q 1.243 0.73
514_L 625_A 1.236 0.72
105_N 308_K 1.232 0.72
313_N 588_R 1.22 0.71
151_K 173_E 1.218 0.71
597_I 606_V 1.217 0.71
575_G 578_D 1.213 0.70
231_A 242_S 1.211 0.70
534_T 562_L 1.211 0.70
232_E 242_S 1.21 0.70
42_Y 231_A 1.208 0.70
505_V 624_V 1.207 0.70
377_A 436_A 1.206 0.70
146_L 288_I 1.205 0.70
14_W 18_N 1.203 0.69
117_V 120_Q 1.202 0.69
377_A 462_E 1.2 0.69
323_W 339_R 1.19 0.68
486_R 501_D 1.19 0.68
381_R 462_E 1.19 0.68
600_N 603_D 1.188 0.68
513_L 516_E 1.187 0.68
672_R 675_L 1.187 0.68
146_L 290_P 1.185 0.68
27_D 650_K 1.185 0.68
105_N 310_N 1.184 0.68
354_L 462_E 1.181 0.67
655_D 663_V 1.18 0.67
482_N 486_R 1.176 0.67
124_R 208_D 1.172 0.66
162_I 220_L 1.17 0.66
559_V 613_W 1.17 0.66
535_L 596_Y 1.169 0.66
76_L 242_S 1.168 0.66
19_E 83_R 1.167 0.66
134_H 442_S 1.161 0.65
151_K 156_Y 1.161 0.65
344_Y 379_D 1.158 0.65
562_L 641_I 1.158 0.65
88_D 92_D 1.155 0.65
74_R 78_G 1.155 0.65
643_I 677_I 1.153 0.65
471_Y 640_I 1.153 0.65
531_S 599_E 1.148 0.64
316_L 678_Y 1.147 0.64
264_Y 268_M 1.145 0.64
511_R 544_G 1.145 0.64
438_L 487_V 1.145 0.64
136_T 492_E 1.143 0.64
152_D 156_Y 1.143 0.64
500_F 505_V 1.14 0.63
665_R 668_R 1.139 0.63
531_S 558_P 1.138 0.63
344_Y 593_D 1.137 0.63
553_S 577_S 1.134 0.63
455_I 480_I 1.134 0.63
227_M 262_F 1.133 0.63
71_S 79_K 1.13 0.62
147_V 660_N 1.13 0.62
197_I 202_I 1.127 0.62
572_N 578_D 1.122 0.62
443_R 452_Y 1.121 0.61
131_L 199_L 1.116 0.61
131_L 202_I 1.112 0.60
95_Y 99_L 1.11 0.60
549_L 580_I 1.108 0.60
333_F 452_Y 1.108 0.60
37_R 467_L 1.104 0.60
146_L 289_V 1.102 0.59
296_N 299_D 1.099 0.59
400_V 414_W 1.094 0.59
596_Y 625_A 1.091 0.58
9_E 76_L 1.088 0.58
24_E 30_N 1.088 0.58
226_K 263_V 1.087 0.58
363_D 443_R 1.085 0.58
28_K 101_E 1.08 0.57
160_E 271_A 1.078 0.57
418_L 423_V 1.077 0.57
281_T 622_I 1.077 0.57
43_S 91_F 1.075 0.57
147_V 195_P 1.075 0.57
182_F 299_D 1.073 0.56
546_V 568_S 1.072 0.56
523_A 526_Q 1.072 0.56
38_F 313_N 1.07 0.56
562_L 583_I 1.07 0.56
571_P 578_D 1.068 0.56
294_Y 660_N 1.068 0.56
152_D 161_I 1.065 0.56
146_L 292_G 1.063 0.55
126_Y 130_Y 1.055 0.54
450_V 476_A 1.052 0.54
244_M 412_I 1.052 0.54
382_I 566_M 1.05 0.54
559_V 580_I 1.049 0.54
287_S 291_G 1.049 0.54
331_N 337_R 1.048 0.54
91_F 95_Y 1.044 0.53
151_K 154_Y 1.041 0.53
586_V 650_K 1.039 0.53
440_L 453_A 1.039 0.53
135_I 282_I 1.037 0.53
115_L 197_I 1.037 0.53
136_T 370_K 1.035 0.52
124_R 209_D 1.033 0.52
224_S 265_Q 1.032 0.52
567_C 582_A 1.027 0.51
314_K 574_E 1.027 0.51
675_L 679_D 1.027 0.51
358_R 385_S 1.024 0.51
526_Q 555_S 1.022 0.51
518_V 549_L 1.02 0.51
400_V 462_E 1.02 0.51
522_I 551_A 1.02 0.51
367_L 449_V 1.018 0.50
541_V 615_T 1.015 0.50
34_E 589_Y 1.015 0.50
28_K 208_D 1.014 0.50
148_Q 293_R 1.014 0.50
232_E 461_N 1.013 0.50
521_E 602_G 1.012 0.50
532_G 597_I 1.011 0.50
248_S 416_K 1.011 0.50
103_A 114_Q 1.01 0.50
418_L 425_V 1.009 0.50
112_E 201_N 1.008 0.49
388_H 506_S 1.005 0.49
597_I 604_K 1.003 0.49
347_Y 644_L 1.003 0.49
147_V 294_Y 1.002 0.49
535_L 559_V 1.001 0.49
371_I 434_I 1.001 0.49
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1xdpA20.99561000.239Contact Map0.663
2o8rA20.98551000.256Contact Map0.683
4gelA20.280599.40.948Contact Map0.612
3hsiA30.502999.20.955Contact Map0.449
1byrA10.219599.10.955Contact Map0.631
4ggjA10.274799.10.956Contact Map0.545
1v0wA10.508799.10.956Contact Map0.436
2c1lA20.271883.10.984Contact Map0.459
1yd0A10.135244.10.988Contact Map0.245
1yd6A40.138127.60.989Contact Map0.315
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
Page generated in 0.2292 seconds.