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OPENSEQ.org
NAGB - Glucosamine-6-phosphate deaminase
UniProt: P0A759 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10633
Length: 266 (249)
Sequences: 2367
Seq/Len: 9.51
NAGB
Paralog alert: 0.34 [within 20: 0.02] - ratio of genomes with paralogs
Cluster includes: AGAI NAGB YIEK
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
87_S 91_R 3.194 1.00
7_T 241_E 2.796 1.00
206_S 242_P 2.778 1.00
117_E 120_Q 2.755 1.00
210_L 246_E 2.658 1.00
51_A 54_E 2.531 1.00
107_L 186_L 2.5 1.00
90_H 95_D 2.461 1.00
123_E 127_S 2.42 1.00
198_E 234_K 2.337 1.00
140_N 207_Q 2.262 1.00
91_R 95_D 2.183 1.00
239_C 244_T 2.177 1.00
212_L 239_C 2.109 1.00
20_I 48_T 2.077 1.00
62_S 98_D 2.073 1.00
22_N 26_A 2.03 1.00
105_N 124_K 2.015 1.00
8_T 11_Q 1.998 1.00
79_K 86_Y 1.924 1.00
44_T 202_L 1.847 1.00
23_R 198_E 1.83 1.00
132_H 197_E 1.827 1.00
12_V 204_L 1.805 1.00
210_L 214_A 1.774 1.00
119_R 123_E 1.762 1.00
9_A 13_G 1.753 1.00
21_V 55_M 1.749 1.00
14_K 51_A 1.744 1.00
13_G 47_T 1.736 1.00
116_A 120_Q 1.709 1.00
194_L 228_C 1.679 1.00
68_T 94_F 1.667 1.00
23_R 35_F 1.661 1.00
213_Q 217_E 1.656 1.00
40_P 71_M 1.654 1.00
138_V 203_V 1.651 1.00
64_K 98_D 1.629 1.00
86_Y 90_H 1.617 1.00
206_S 245_M 1.595 1.00
19_H 238_V 1.588 1.00
134_F 196_A 1.585 1.00
6_L 15_W 1.578 1.00
18_R 55_M 1.563 1.00
67_V 105_N 1.56 1.00
16_A 48_T 1.55 1.00
164_H 168_V 1.542 1.00
203_V 212_L 1.528 1.00
69_F 128_Y 1.507 1.00
20_I 37_L 1.504 1.00
70_N 89_M 1.461 1.00
74_Y 77_L 1.448 1.00
48_T 135_M 1.431 1.00
177_D 180_Q 1.43 1.00
28_K 33_R 1.423 0.99
161_T 184_Y 1.421 0.99
82_P 87_S 1.42 0.99
86_Y 106_L 1.414 0.99
120_Q 124_K 1.412 0.99
145_A 193_L 1.406 0.99
9_A 47_T 1.404 0.99
67_V 103_N 1.404 0.99
199_V 235_A 1.399 0.99
142_G 224_W 1.396 0.99
75_V 114_I 1.377 0.99
125_I 131_I 1.366 0.99
46_M 92_N 1.36 0.99
156_R 195_D 1.355 0.99
99_I 103_N 1.32 0.99
6_L 12_V 1.317 0.99
113_D 116_A 1.298 0.99
188_V 192_T 1.287 0.99
138_V 215_A 1.284 0.99
175_D 180_Q 1.284 0.99
54_E 58_A 1.28 0.99
151_S 158_R 1.267 0.99
38_G 134_F 1.266 0.99
32_D 197_E 1.261 0.98
24_I 66_V 1.261 0.98
215_A 237_M 1.255 0.98
24_I 35_F 1.247 0.98
18_R 22_N 1.243 0.98
209_A 245_M 1.242 0.98
50_K 92_N 1.228 0.98
46_M 50_K 1.222 0.98
21_V 61_V 1.22 0.98
16_A 200_M 1.215 0.98
90_H 101_A 1.197 0.98
214_A 224_W 1.193 0.98
67_V 100_P 1.189 0.98
212_L 237_M 1.186 0.97
240_D 243_S 1.181 0.97
6_L 238_V 1.179 0.97
9_A 204_L 1.174 0.97
244_T 247_L 1.172 0.97
25_N 60_Q 1.169 0.97
5_P 244_T 1.169 0.97
38_G 71_M 1.165 0.97
56_H 60_Q 1.165 0.97
212_L 215_A 1.145 0.97
120_Q 123_E 1.143 0.97
111_A 114_I 1.141 0.97
19_H 198_E 1.134 0.96
94_F 104_I 1.13 0.96
16_A 202_L 1.122 0.96
12_V 238_V 1.116 0.96
21_V 25_N 1.115 0.96
43_G 88_F 1.11 0.96
20_I 133_L 1.108 0.96
84_S 87_S 1.097 0.96
62_S 65_H 1.095 0.95
19_H 200_M 1.094 0.95
80_E 87_S 1.094 0.95
115_D 119_R 1.091 0.95
48_T 202_L 1.09 0.95
114_I 159_I 1.081 0.95
126_R 195_D 1.08 0.95
36_V 67_V 1.067 0.95
100_P 103_N 1.067 0.95
36_V 69_F 1.055 0.94
111_A 117_E 1.048 0.94
116_A 119_R 1.047 0.94
122_E 192_T 1.047 0.94
4_I 238_V 1.044 0.94
44_T 204_L 1.041 0.94
35_F 66_V 1.036 0.93
53_V 96_H 1.036 0.93
43_G 173_F 1.028 0.93
133_L 200_M 1.027 0.93
51_A 55_M 1.027 0.93
88_F 92_N 1.02 0.93
125_I 130_K 1.018 0.93
28_K 65_H 1.012 0.92
16_A 238_V 1.008 0.92
198_E 236_I 1.006 0.92
101_A 104_I 1.003 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3icoA40.87971000.15Contact Map0.765
3oc6A10.86471000.15Contact Map0.733
3tx2A10.86841000.151Contact Map0.707
3eb9A20.87591000.171Contact Map0.728
1ne7A60.99621000.199Contact Map0.872
3lwdA10.83831000.201Contact Map0.536
3e15A40.94741000.201Contact Map0.632
1fs5A20.99621000.201Contact Map0.843
1vl1A10.81581000.202Contact Map0.703
3hn6A60.99621000.207Contact Map0.9
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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