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MSRB - Peptide methionine sulfoxide reductase MsrB
UniProt: P0A746 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12394
Length: 137 (126)
Sequences: 2216
Seq/Len: 17.59

MSRB
Paralog alert: 0.20 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
15_S 18_Q 3.352 1.00
33_G 121_S 3.082 1.00
20_Y 24_N 3.01 1.00
81_I 94_R 2.756 1.00
20_Y 26_G 2.629 1.00
84_L 89_Q 2.619 1.00
25_H 94_R 2.586 1.00
48_I 100_A 2.532 1.00
22_T 100_A 2.522 1.00
93_I 119_V 2.407 1.00
18_Q 47_L 2.376 1.00
82_K 89_Q 2.146 1.00
70_Y 112_P 2.103 1.00
39_K 62_S 2.07 1.00
58_T 70_Y 2.047 1.00
51_A 96_G 1.991 1.00
51_A 97_N 1.979 1.00
49_C 98_C 1.935 1.00
54_F 117_Y 1.91 1.00
22_T 48_I 1.907 1.00
45_H 127_T 1.871 1.00
38_N 126_F 1.81 1.00
85_S 88_M 1.702 1.00
41_D 129_G 1.682 1.00
22_T 47_L 1.68 1.00
107_P 115_E 1.665 1.00
23_Q 48_I 1.638 1.00
21_V 122_A 1.602 1.00
79_R 94_R 1.565 1.00
34_R 121_S 1.537 1.00
80_Y 115_E 1.493 1.00
95_C 98_C 1.48 1.00
29_P 32_T 1.471 1.00
79_R 99_D 1.467 1.00
51_A 77_S 1.42 1.00
10_L 23_Q 1.418 1.00
25_H 81_I 1.409 1.00
108_D 114_G 1.396 0.99
17_M 20_Y 1.393 0.99
35_L 38_N 1.391 0.99
94_R 99_D 1.334 0.99
58_T 71_E 1.328 0.99
39_K 61_D 1.328 0.99
6_S 9_E 1.324 0.99
79_R 96_G 1.317 0.99
34_R 125_R 1.306 0.99
7_A 24_N 1.279 0.99
36_L 39_K 1.278 0.99
45_H 50_D 1.26 0.99
52_P 73_V 1.25 0.99
19_F 23_Q 1.201 0.98
9_E 12_K 1.142 0.97
46_C 95_C 1.132 0.97
41_D 57_Q 1.122 0.97
86_H 89_Q 1.119 0.96
16_E 20_Y 1.109 0.96
43_V 52_P 1.099 0.96
38_N 44_Y 1.093 0.96
40_R 128_D 1.073 0.95
46_C 98_C 1.068 0.95
11_K 19_F 1.067 0.95
70_Y 113_T 1.064 0.95
74_S 77_S 1.057 0.95
35_L 126_F 1.051 0.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2k8dA10.97081000.043Contact Map0.467
3cxkA20.97081000.045Contact Map0.764
3e0mA411000.049Contact Map0.816
3e0oA60.98541000.051Contact Map0.816
3hcgA40.99271000.053Contact Map0.833
3hcjA20.99271000.057Contact Map0.682
2l1uA10.95621000.061Contact Map0.327
3maoA10.75911000.277Contact Map0.653
2kaoA10.81021000.287Contact Map0.249
3ky9A20.605818.30.953Contact Map0.332

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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