OPENSEQ.org - MOAC - ECOLI GREMLIN

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MOAC - Cyclic pyranopterin monophosphate synthase accessory protein

UniProt:	P0A738	Sequence MSQLTHINAAGEAHMVDVSAKAETVREARAEAFVTMRSETLAMIIDGRHHKGDVFATARIAGIQAAKRTWDLIPLCHPLMLSKVEVNLQAEPEHNRVRIETLCRLTGKTGVEMEALTAASVAALTIYDMCKAVQKDMVIGPVRLLAKSGGKSGDFKVEADD	Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene:	EG11666
Length:	161 (156)
Sequences:	1428
Seq/Len:	9.15

MOAC
Paralog alert: 0.03 [within 20: 0.00] - ratio of genomes with paralogs

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Scaled Score	Prob
68_R	71_D	5.413	1.00
99_I	123_A	3.463	1.00
101_T	118_A	3.332	1.00
32_A	119_A	3.029	1.00
43_M	133_V	2.975	1.00
146_A	154_D	2.81	1.00
32_A	142_V	2.767	1.00
31_E	145_L	2.747	1.00
42_A	46_D	2.61	1.00
31_E	98_R	2.554	1.00
8_N	12_E	2.506	1.00
23_E	108_K	2.422	1.00
35_T	140_G	2.41	1.00
146_A	156_K	2.073	1.00
31_E	143_R	1.991	1.00
62_G	122_A	1.989	1.00
148_S	154_D	1.901	1.00
25_V	104_R	1.888	1.00
66_A	118_A	1.863	1.00
120_S	142_V	1.832	1.00
36_M	40_T	1.831	1.00
136_D	155_F	1.816	1.00
34_V	123_A	1.756	1.00
33_F	96_R	1.754	1.00
91_E	94_H	1.7	1.00
7_I	57_T	1.675	1.00
127_Y	144_L	1.663	1.00
27_E	102_L	1.659	1.00
90_A	97_V	1.642	1.00
29_R	102_L	1.569	1.00
72_L	121_V	1.514	1.00
33_F	98_R	1.49	1.00
135_K	152_S	1.478	1.00
41_L	90_A	1.476	1.00
37_R	40_T	1.474	1.00
88_L	97_V	1.457	1.00
32_A	123_A	1.444	1.00
62_G	86_V	1.435	0.99
60_I	75_L	1.409	0.99
38_S	42_A	1.388	0.99
45_I	90_A	1.383	0.99
130_C	137_M	1.379	0.99
72_L	117_T	1.376	0.99
89_Q	98_R	1.368	0.99
45_I	92_P	1.348	0.99
80_M	105_L	1.331	0.99
53_D	56_A	1.325	0.99
33_F	141_P	1.314	0.99
44_I	130_C	1.312	0.99
83_K	104_R	1.302	0.99
80_M	107_G	1.296	0.99
123_A	139_I	1.296	0.99
35_T	138_V	1.279	0.99
17_D	104_R	1.269	0.98
19_S	82_S	1.257	0.98
143_R	157_V	1.245	0.98
56_A	59_R	1.245	0.98
34_V	137_M	1.241	0.98
81_L	103_C	1.239	0.98
19_S	104_R	1.208	0.98
27_E	104_R	1.196	0.97
116_L	124_L	1.184	0.97
138_V	141_P	1.181	0.97
62_G	101_T	1.18	0.97
120_S	139_I	1.174	0.97
27_E	148_S	1.173	0.97
43_M	49_H	1.17	0.97
119_A	142_V	1.126	0.96
23_E	106_T	1.125	0.96
81_L	111_V	1.12	0.96
31_E	100_E	1.104	0.95
79_L	103_C	1.072	0.94
13_A	56_A	1.066	0.94
29_R	146_A	1.056	0.94
39_E	42_A	1.05	0.94
66_A	81_L	1.049	0.93
57_T	60_I	1.031	0.93
12_E	59_R	1.03	0.93
91_E	98_R	1.027	0.92
34_V	126_I	1.022	0.92
89_Q	100_E	1.019	0.92
101_T	119_A	1.009	0.92
87_N	100_E	1.005	0.91

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling

HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:

Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	P(%)	HHΔ		Acc
1ekrA	1	1	100	-0.01	Contact Map	0.689
2eeyA	1	0.9938	100	-0.004	Contact Map	0.728
4fdfA	2	0.9876	100	0.012	Contact Map	0.792
2iihA	1	0.9752	100	0.024	Contact Map	0.75
2eknA	3	0.9379	100	0.064	Contact Map	0.9
2ohdA	6	0.8944	100	0.113	Contact Map	0.932
1ccwB	2	0.3665	8.1	0.962	Contact Map	0.389
1gvpA	1	0.1863	4.4	0.966	Contact Map	0.095
3mhsE	1	0.2857	4.3	0.967	Contact Map	0.184
3bkrA	1	0.4161	4.1	0.967	Contact Map	0.792

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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