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OPENSEQ.org

HYPA - Protein HypA
UniProt: P0A700 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10483
Length: 116 (114)
Sequences: 780
Seq/Len: 6.84

HYPA
Paralog alert: 0.48 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: HYBF HYPA
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
48_F 62_L 2.963 1.00
48_F 60_C 2.641 1.00
75_T 97_M 2.548 1.00
23_A 113_I 2.394 1.00
32_K 107_Q 2.354 1.00
28_G 63_H 2.189 1.00
32_K 65_E 2.11 1.00
28_G 61_K 2.032 1.00
17_Q 20_K 1.97 1.00
32_K 109_R 1.967 1.00
72_W 79_Y 1.962 1.00
72_W 99_Q 1.96 1.00
72_W 77_Q 1.922 1.00
14_I 26_V 1.91 1.00
27_T 114_D 1.719 1.00
52_C 59_G 1.697 1.00
18_A 56_V 1.684 1.00
54_G 58_E 1.67 1.00
6_L 39_V 1.656 1.00
14_I 111_I 1.598 1.00
78_Q 92_Q 1.571 1.00
35_A 66_E 1.57 1.00
7_C 44_L 1.569 1.00
55_S 58_E 1.554 0.99
30_W 110_R 1.523 0.99
18_A 23_A 1.519 0.99
9_R 13_L 1.505 0.99
70_E 102_A 1.493 0.99
71_C 80_V 1.492 0.99
43_S 46_F 1.471 0.99
74_E 99_Q 1.458 0.99
70_E 79_Y 1.451 0.99
71_C 98_L 1.435 0.99
35_A 68_E 1.393 0.99
108_I 111_I 1.38 0.99
34_G 103_D 1.365 0.98
6_L 38_C 1.345 0.98
71_C 82_L 1.315 0.98
30_W 63_H 1.297 0.98
14_I 108_I 1.286 0.97
53_R 58_E 1.251 0.97
80_V 98_L 1.242 0.97
25_R 59_G 1.226 0.96
31_L 64_L 1.226 0.96
41_T 66_E 1.204 0.96
7_C 43_S 1.169 0.95
28_G 112_E 1.154 0.94
25_R 114_D 1.139 0.94
67_Q 105_G 1.136 0.94
8_Q 51_V 1.122 0.93
11_L 51_V 1.115 0.93
12_E 15_E 1.113 0.93
11_L 57_A 1.096 0.92
79_Y 101_V 1.07 0.91
14_I 29_V 1.062 0.90
5_T 9_R 1.054 0.90
10_A 31_L 1.053 0.90
43_S 47_C 1.049 0.89
13_L 108_I 1.04 0.89
18_A 26_V 1 0.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3a43A20.99141000.031Contact Map0.803
2kdxA10.99141000.049Contact Map0.716
2k2dA10.6379990.667Contact Map0.706
3pwfA20.810395.50.824Contact Map0.53
1lkoA10.862195.50.824Contact Map0.482
2lcqA10.8879950.83Contact Map0.378
4aybP10.379394.90.831Contact Map0.041
1yuzA20.775993.90.839Contact Map0.609
1s24A10.551781.20.873Contact Map0.729
3h0gL20.543180.70.873Contact Map0.593

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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