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OPENSEQ.org
HTPG - Chaperone protein HtpG
UniProt: P0A6Z3 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10461
Length: 624 (620)
Sequences: 1520
Seq/Len: 2.45
HTPG
Paralog alert: 0.09 [within 20: 0.02] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
74_R 185_D 5.022 1.00
140_R 177_T 4.877 1.00
79_S 175_E 4.416 1.00
150_N 166_D 4.265 1.00
94_L 139_V 4.031 1.00
70_D 73_K 3.851 1.00
367_D 370_K 3.827 1.00
67_V 197_I 3.501 1.00
417_E 475_F 3.355 1.00
136_K 155_E 3.283 1.00
404_S 458_L 3.217 1.00
435_A 441_A 3.168 1.00
247_K 259_D 3.061 1.00
418_D 421_S 2.92 1.00
64_R 209_E 2.884 1.00
509_T 513_D 2.884 1.00
422_R 456_E 2.859 1.00
398_K 417_E 2.832 1.00
506_K 509_T 2.79 1.00
598_D 617_R 2.74 1.00
186_E 192_R 2.732 1.00
516_K 525_D 2.713 1.00
71_K 189_D 2.692 1.00
90_V 141_T 2.668 1.00
138_T 155_E 2.633 1.00
513_D 517_A 2.627 1.00
397_A 472_L 2.617 1.00
241_I 245_E 2.574 1.00
515_V 593_V 2.564 1.00
140_R 153_F 2.551 1.00
90_V 152_V 2.508 1.00
417_E 476_D 2.469 1.00
138_T 179_H 2.465 1.00
398_K 475_F 2.453 1.00
36_I 197_I 2.427 1.00
515_V 570_L 2.423 1.00
104_S 107_E 2.402 1.00
135_D 182_E 2.365 1.00
197_I 227_I 2.363 1.00
438_Y 442_K 2.356 1.00
251_K 259_D 2.302 1.00
151_G 167_I 2.268 1.00
29_E 192_R 2.262 1.00
325_I 352_L 2.26 1.00
474_E 477_G 2.161 1.00
190_D 194_R 2.146 1.00
405_T 456_E 2.112 1.00
43_A 63_L 2.111 1.00
404_S 414_V 2.109 1.00
135_D 179_H 2.06 1.00
500_S 503_E 2.049 0.99
88_D 92_D 2.019 0.99
89_E 143_A 2.015 0.99
406_H 454_G 2.01 0.99
130_A 137_V 2.009 0.99
68_S 79_S 2.001 0.99
405_T 459_L 1.952 0.99
414_V 422_R 1.929 0.99
247_K 260_P 1.909 0.99
591_E 620_Q 1.899 0.99
524_K 542_D 1.888 0.99
194_R 225_E 1.879 0.99
66_R 209_E 1.876 0.99
243_D 247_K 1.869 0.99
192_R 195_S 1.856 0.99
140_R 167_I 1.85 0.99
243_D 263_W 1.847 0.99
450_L 483_V 1.808 0.98
364_A 401_R 1.807 0.98
406_H 424_K 1.798 0.98
283_Q 377_Q 1.797 0.98
211_E 224_W 1.796 0.98
523_V 526_V 1.789 0.98
242_T 245_E 1.784 0.98
550_M 554_F 1.784 0.98
502_K 506_K 1.781 0.98
469_M 480_F 1.775 0.98
528_L 570_L 1.771 0.98
28_K 184_E 1.735 0.98
401_R 415_S 1.731 0.98
153_F 165_A 1.72 0.98
134_A 178_L 1.712 0.98
402_F 460_L 1.703 0.97
247_K 263_W 1.702 0.97
244_E 248_E 1.682 0.97
75_T 177_T 1.677 0.97
499_E 502_K 1.675 0.97
578_K 582_D 1.673 0.97
382_L 396_I 1.661 0.97
86_T 143_A 1.65 0.97
140_R 175_E 1.644 0.97
417_E 420_V 1.637 0.97
130_A 178_L 1.636 0.97
429_K 479_P 1.602 0.96
136_K 179_H 1.596 0.96
517_A 520_G 1.595 0.96
448_E 535_T 1.592 0.96
503_E 506_K 1.591 0.96
209_E 226_K 1.583 0.96
49_R 56_L 1.583 0.96
180_L 188_L 1.57 0.95
5_E 87_R 1.57 0.95
90_V 94_L 1.563 0.95
138_T 177_T 1.556 0.95
49_R 143_A 1.555 0.95
244_E 247_K 1.555 0.95
155_E 163_T 1.532 0.95
236_R 245_E 1.527 0.94
549_Q 552_K 1.508 0.94
364_A 415_S 1.506 0.94
314_M 352_L 1.504 0.94
282_S 373_T 1.502 0.94
360_L 399_L 1.499 0.94
474_E 479_P 1.499 0.94
94_L 164_V 1.496 0.94
43_A 206_L 1.493 0.93
67_V 193_V 1.486 0.93
280_I 360_L 1.482 0.93
71_K 188_L 1.481 0.93
373_T 376_Q 1.465 0.93
423_M 478_K 1.444 0.92
356_V 360_L 1.441 0.92
518_L 593_V 1.44 0.92
503_E 507_A 1.438 0.92
24_L 334_V 1.436 0.92
414_V 458_L 1.436 0.92
211_E 222_I 1.428 0.91
66_R 79_S 1.422 0.91
429_K 481_Q 1.414 0.91
250_Y 256_D 1.412 0.91
262_T 359_M 1.408 0.91
447_L 483_V 1.404 0.90
248_E 251_K 1.398 0.90
136_K 157_A 1.395 0.90
69_F 193_V 1.39 0.90
405_T 422_R 1.381 0.89
362_K 366_D 1.38 0.89
258_N 282_S 1.379 0.89
450_L 488_E 1.377 0.89
321_V 356_V 1.353 0.88
369_E 373_T 1.349 0.88
522_R 594_E 1.348 0.88
305_F 308_D 1.347 0.88
36_I 67_V 1.345 0.88
29_E 199_K 1.342 0.88
102_T 119_L 1.341 0.88
384_E 388_E 1.336 0.87
504_A 573_D 1.327 0.87
78_I 176_I 1.314 0.86
141_T 152_V 1.303 0.85
403_A 438_Y 1.3 0.85
420_V 476_D 1.296 0.85
414_V 456_E 1.292 0.85
32_L 78_I 1.29 0.85
331_P 342_S 1.286 0.84
502_K 505_E 1.281 0.84
258_N 283_Q 1.278 0.84
394_E 476_D 1.268 0.83
267_R 275_T 1.262 0.83
439_A 442_K 1.258 0.83
610_D 613_L 1.257 0.83
67_V 227_I 1.25 0.82
66_R 224_W 1.249 0.82
89_E 92_D 1.246 0.82
209_E 224_W 1.244 0.82
570_L 577_V 1.236 0.81
616_R 620_Q 1.232 0.81
260_P 263_W 1.232 0.81
417_E 421_S 1.231 0.81
243_D 370_K 1.228 0.80
15_Q 103_K 1.227 0.80
102_T 269_E 1.224 0.80
389_D 392_N 1.221 0.80
64_R 81_N 1.22 0.80
138_T 153_F 1.214 0.79
233_L 241_I 1.214 0.79
615_I 619_N 1.212 0.79
74_R 182_E 1.208 0.79
294_K 311_E 1.208 0.79
99_K 104_S 1.208 0.79
370_K 373_T 1.195 0.78
280_I 321_V 1.189 0.77
428_E 492_K 1.182 0.77
259_D 282_S 1.18 0.77
30_I 129_S 1.18 0.77
424_K 454_G 1.176 0.76
169_K 175_E 1.175 0.76
319_R 384_E 1.163 0.75
420_V 478_K 1.157 0.75
595_L 614_F 1.153 0.74
77_T 177_T 1.149 0.74
368_A 372_Q 1.147 0.74
405_T 447_L 1.147 0.74
71_K 190_D 1.147 0.74
297_L 314_M 1.146 0.74
442_K 459_L 1.137 0.73
531_R 538_I 1.135 0.73
77_T 175_E 1.125 0.72
371_Y 399_L 1.123 0.72
90_V 139_V 1.122 0.71
246_Y 265_H 1.119 0.71
67_V 498_D 1.118 0.71
151_G 170_E 1.116 0.71
375_W 382_L 1.114 0.71
21_I 30_I 1.11 0.70
72_D 136_K 1.1 0.69
579_R 582_D 1.097 0.69
531_R 540_S 1.088 0.68
532_L 538_I 1.088 0.68
450_L 455_I 1.085 0.68
361_E 398_K 1.082 0.67
237_N 240_E 1.077 0.67
246_Y 279_Y 1.076 0.67
590_S 594_E 1.075 0.67
591_E 617_R 1.074 0.67
366_D 369_E 1.071 0.66
46_L 172_R 1.07 0.66
189_D 192_R 1.066 0.66
534_D 616_R 1.066 0.66
193_V 227_I 1.064 0.66
167_I 170_E 1.063 0.65
307_M 310_A 1.059 0.65
135_D 181_R 1.059 0.65
104_S 108_S 1.057 0.65
408_D 442_K 1.05 0.64
214_E 221_V 1.048 0.64
266_N 355_R 1.048 0.64
420_V 475_F 1.046 0.64
151_G 171_D 1.045 0.63
4_Q 165_A 1.043 0.63
512_I 528_L 1.042 0.63
263_W 279_Y 1.041 0.63
402_F 414_V 1.037 0.63
398_K 476_D 1.037 0.63
69_F 189_D 1.03 0.62
213_R 222_I 1.028 0.62
63_L 172_R 1.027 0.61
86_T 146_E 1.018 0.60
505_E 509_T 1.016 0.60
34_E 38_N 1.015 0.60
75_T 179_H 1.012 0.60
312_Q 349_R 1.011 0.60
295_H 560_K 1.008 0.59
236_R 240_E 1.007 0.59
553_L 556_A 1.006 0.59
395_A 398_K 1.006 0.59
31_F 133_V 1.002 0.59
196_I 224_W 1.002 0.59
524_K 565_K 1.001 0.59
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2cg9A20.98241000.159Contact Map0.715
2ioqA211000.166Contact Map0.696
2o1uA20.9841000.191Contact Map0.784
1y4sA20.89581000.245Contact Map0.805
3hjcA10.65381000.431Contact Map0.772
3q6mA30.62981000.433Contact Map0.835
2cgeA30.6251000.438Contact Map0.712
2gq0A20.48561000.56Contact Map0.865
1hk7A20.45991000.569Contact Map0.867
1y6zA20.41351000.583Contact Map0.836
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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