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OPENSEQ.org
HSLO - 33 kDa chaperonin
UniProt: P0A6Y5 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12930
Length: 292 (283)
Sequences: 1093
Seq/Len: 3.86
HSLO
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
83_N 87_Q 4.358 1.00
72_D 110_N 3.667 1.00
29_Q 32_L 3.189 1.00
250_D 254_A 3.14 1.00
241_L 249_V 3.074 1.00
24_V 50_V 2.815 1.00
251_S 255_E 2.745 1.00
42_K 164_K 2.734 1.00
52_T 80_I 2.57 1.00
22_V 50_V 2.371 1.00
89_R 231_T 2.23 1.00
34_N 268_N 2.23 1.00
257_G 274_A 2.211 1.00
248_E 251_S 2.118 1.00
234_R 276_D 2.057 1.00
258_E 271_L 2.021 1.00
49_L 90_G 2.005 1.00
103_D 106_T 1.988 1.00
87_Q 227_E 1.988 1.00
51_A 156_I 1.913 1.00
249_V 281_R 1.9 1.00
30_Q 34_N 1.884 1.00
234_R 272_F 1.884 1.00
10_Y 19_G 1.869 1.00
262_H 269_H 1.864 1.00
137_A 156_I 1.847 1.00
19_G 209_L 1.842 1.00
48_L 78_A 1.83 1.00
31_I 49_L 1.828 1.00
113_V 129_V 1.827 1.00
30_Q 33_E 1.815 0.99
34_N 228_F 1.81 0.99
232_C 263_C 1.761 0.99
274_A 278_A 1.742 0.99
246_D 250_D 1.731 0.99
53_S 226_V 1.72 0.99
114_V 126_Q 1.696 0.99
81_N 89_R 1.666 0.99
19_G 213_Y 1.61 0.99
66_T 81_N 1.607 0.98
75_M 92_A 1.598 0.98
45_L 90_G 1.597 0.98
141_E 145_M 1.596 0.98
237_C 261_M 1.572 0.98
95_Q 98_I 1.56 0.98
52_T 67_V 1.549 0.98
55_L 144_F 1.482 0.97
52_T 82_G 1.475 0.97
207_E 210_W 1.473 0.97
190_T 194_T 1.468 0.97
237_C 240_A 1.465 0.97
275_M 278_A 1.458 0.97
230_C 266_C 1.45 0.97
187_H 216_E 1.42 0.96
113_V 131_L 1.398 0.96
159_G 163_G 1.393 0.95
101_N 163_G 1.389 0.95
273_N 276_D 1.389 0.95
144_F 152_T 1.388 0.95
9_R 20_E 1.384 0.95
252_I 258_E 1.378 0.95
232_C 266_C 1.364 0.95
190_T 193_E 1.348 0.94
51_A 140_L 1.343 0.94
95_Q 197_T 1.343 0.94
37_Y 42_K 1.337 0.94
263_C 266_C 1.325 0.94
100_E 163_G 1.321 0.93
68_Q 126_Q 1.321 0.93
204_P 207_E 1.313 0.93
100_E 197_T 1.298 0.93
203_L 211_R 1.289 0.92
45_L 228_F 1.276 0.92
6_Q 206_N 1.273 0.92
191_L 194_T 1.273 0.92
170_M 192_T 1.272 0.92
16_A 184_D 1.258 0.91
6_Q 205_A 1.25 0.91
13_E 219_T 1.245 0.91
191_L 215_E 1.243 0.90
159_G 202_T 1.239 0.90
14_N 217_E 1.231 0.90
230_C 263_C 1.213 0.89
8_H 205_A 1.212 0.89
253_L 277_I 1.212 0.89
234_R 238_A 1.207 0.89
105_K 134_D 1.207 0.89
44_V 75_M 1.205 0.89
71_G 109_G 1.204 0.88
41_V 92_A 1.2 0.88
183_D 186_D 1.194 0.88
69_L 78_A 1.193 0.88
28_L 46_A 1.192 0.88
41_V 75_M 1.189 0.88
180_A 186_D 1.18 0.87
260_D 269_H 1.177 0.87
238_A 272_F 1.173 0.87
54_L 58_T 1.166 0.86
244_L 249_V 1.153 0.85
6_Q 223_P 1.15 0.85
166_A 201_L 1.148 0.85
165_P 202_T 1.146 0.85
238_A 242_K 1.144 0.85
95_Q 100_E 1.143 0.85
198_E 201_L 1.128 0.84
36_D 97_E 1.109 0.82
48_L 80_I 1.108 0.82
191_L 216_E 1.097 0.81
48_L 136_L 1.084 0.80
101_N 162_D 1.082 0.80
183_D 187_H 1.08 0.80
64_D 81_N 1.08 0.80
127_G 143_Y 1.077 0.80
18_R 228_F 1.076 0.79
100_E 159_G 1.068 0.79
174_V 185_F 1.066 0.79
191_L 214_H 1.062 0.78
98_I 101_N 1.055 0.78
245_P 265_Y 1.054 0.78
245_P 248_E 1.051 0.77
99_P 103_D 1.051 0.77
154_L 171_L 1.049 0.77
203_L 208_V 1.046 0.77
48_L 67_V 1.046 0.77
5_D 27_T 1.046 0.77
199_E 211_R 1.045 0.77
56_T 144_F 1.034 0.76
54_L 169_G 1.032 0.75
186_D 190_T 1.024 0.75
242_K 245_P 1.024 0.75
95_Q 163_G 1.014 0.74
50_V 167_A 1.013 0.73
247_E 254_A 1.006 0.73
7_L 57_A 1.002 0.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1i7fA111000.018Contact Map0.566
1vzyA20.95891000.063Contact Map0.806
1vq0A20.97261000.084Contact Map0.816
1hw7A10.86641000.163Contact Map0.575
2xigA40.359625.30.964Contact Map0.445
1hqmD10.311617.90.966Contact Map0.012
2ds5A20.116416.40.967Contact Map0.458
3eyyA20.345914.60.968Contact Map0.495
3iixA10.315111.70.969Contact Map0.466
1ovxA20.150710.50.97Contact Map0.532
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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