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OPENSEQ.org

IHFA - Integration host factor subunit alpha
UniProt: P0A6X7 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10440
Length: 99 (92)
Sequences: 2908
Seq/Len: 31.61

IHFA
Paralog alert: 0.56 [within 20: 0.04] - ratio of genomes with paralogs
Cluster includes: DBHA DBHB IHFA IHFB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
55_R 80_T 3.643 1.00
61_P 70_D 3.041 1.00
24_K 28_E 2.882 1.00
59_Q 72_P 2.814 1.00
56_D 77_R 2.805 1.00
62_G 73_I 2.586 1.00
37_A 42_E 2.547 1.00
63_R 68_G 2.544 1.00
10_E 20_K 2.432 1.00
85_Q 89_S 2.408 1.00
12_L 27_V 2.256 1.00
61_P 72_P 2.205 1.00
22_D 25_E 2.159 1.00
54_L 77_R 2.134 1.00
57_K 78_V 1.865 1.00
30_F 34_I 1.77 1.00
63_R 70_D 1.727 1.00
38_L 87_L 1.596 1.00
43_Q 53_D 1.573 1.00
53_D 82_R 1.548 1.00
21_R 25_E 1.522 1.00
43_Q 51_N 1.448 1.00
38_L 54_L 1.448 1.00
11_Y 15_K 1.441 1.00
19_S 22_D 1.429 1.00
47_S 84_G 1.407 0.99
56_D 75_A 1.401 0.99
23_A 26_L 1.339 0.99
59_Q 75_A 1.296 0.99
35_R 87_L 1.29 0.99
34_I 44_V 1.234 0.98
66_K 69_E 1.226 0.98
50_G 81_F 1.212 0.98
15_K 36_R 1.203 0.98
18_L 23_A 1.189 0.98
11_Y 33_E 1.129 0.97
39_E 90_R 1.111 0.96
12_L 30_F 1.099 0.96
11_Y 14_D 1.072 0.95
49_F 52_F 1.068 0.95
16_L 23_A 1.064 0.95
10_E 14_D 1.038 0.94
15_K 32_E 1.037 0.94
32_E 35_R 1.029 0.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1owfA111000.102Contact Map0.682
2iieA1199.90.147Contact Map0.765
2o97B10.909199.90.165Contact Map0.614
3c4iA20.979899.90.169Contact Map0.875
1mulA10.909199.90.169Contact Map0.776
1b8zA20.909199.90.169Contact Map0.813
1exeA20.979899.90.171Contact Map0.64
1p71A20.949599.90.173Contact Map0.82
1owfB10.939499.90.175Contact Map0.675
3rhiA40.929399.90.175Contact Map0.916

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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