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OPENSEQ.org
GLK - Glucokinase
UniProt: P0A6V8 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12957
Length: 321 (317)
Sequences: 659
Seq/Len: 2.08
GLK
Paralog alert: 0.05 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
135_A 241_M 2.913 1.00
101_F 134_G 2.908 1.00
188_R 286_R 2.775 1.00
169_E 232_R 2.609 1.00
120_G 278_R 2.535 1.00
38_Y 47_V 2.444 1.00
278_R 282_E 2.387 1.00
104_V 261_A 2.375 1.00
162_D 247_N 2.139 0.99
196_V 215_P 2.137 0.99
70_D 83_I 2.115 0.99
118_Q 297_Y 2.059 0.99
131_A 258_V 1.993 0.99
180_E 200_R 1.971 0.99
31_K 51_E 1.953 0.99
128_K 255_F 1.892 0.98
305_G 309_S 1.89 0.98
120_G 282_E 1.878 0.98
288_K 292_H 1.825 0.98
260_I 265_V 1.802 0.98
198_L 202_I 1.788 0.98
185_S 188_R 1.762 0.97
244_F 251_N 1.749 0.97
141_V 244_F 1.732 0.97
249_A 294_I 1.728 0.97
246_G 284_K 1.713 0.97
10_V 61_I 1.692 0.96
234_L 271_F 1.66 0.96
35_G 77_H 1.639 0.95
115_H 301_H 1.628 0.95
195_L 233_A 1.615 0.95
177_L 189_V 1.613 0.95
195_L 234_L 1.606 0.95
135_A 265_V 1.588 0.94
185_S 285_G 1.581 0.94
101_F 305_G 1.577 0.94
269_L 298_L 1.55 0.93
70_D 82_S 1.547 0.93
177_L 197_N 1.544 0.93
188_R 285_G 1.543 0.93
98_I 312_H 1.531 0.93
215_P 219_T 1.523 0.92
241_M 265_V 1.515 0.92
261_A 305_G 1.5 0.92
137_T 192_G 1.496 0.92
108_I 132_V 1.49 0.91
202_I 229_D 1.485 0.91
171_A 178_R 1.457 0.90
107_A 304_P 1.454 0.90
161_V 186_A 1.45 0.90
173_I 201_A 1.45 0.90
40_S 43_A 1.449 0.90
234_L 268_F 1.449 0.90
278_R 296_V 1.445 0.90
243_R 280_A 1.434 0.89
238_C 275_S 1.433 0.89
60_C 98_I 1.425 0.89
12_G 137_T 1.42 0.88
62_A 132_V 1.41 0.88
141_V 251_N 1.408 0.88
176_I 201_A 1.407 0.88
245_G 281_F 1.395 0.87
220_E 224_A 1.392 0.87
104_V 305_G 1.388 0.87
83_I 95_L 1.379 0.86
13_T 137_T 1.364 0.86
81_F 97_I 1.351 0.85
105_S 153_S 1.342 0.84
139_L 186_A 1.322 0.83
221_R 230_C 1.32 0.83
9_D 13_T 1.32 0.83
10_V 15_A 1.317 0.83
242_G 246_G 1.315 0.83
163_F 240_I 1.307 0.82
105_S 254_T 1.3 0.82
17_L 44_V 1.295 0.81
192_G 263_G 1.284 0.81
162_D 199_Y 1.279 0.80
139_L 158_G 1.278 0.80
238_C 268_F 1.276 0.80
277_F 296_V 1.27 0.80
189_V 198_L 1.263 0.79
134_G 305_G 1.251 0.78
98_I 102_T 1.247 0.78
177_L 246_G 1.244 0.78
261_A 299_I 1.238 0.77
105_S 144_L 1.234 0.77
289_E 292_H 1.234 0.77
185_S 286_R 1.223 0.76
163_F 189_V 1.222 0.76
43_A 46_R 1.216 0.75
161_V 251_N 1.21 0.75
181_I 188_R 1.207 0.75
254_T 258_V 1.206 0.74
104_V 299_I 1.196 0.74
133_Y 245_G 1.193 0.73
183_H 284_K 1.193 0.73
62_A 104_V 1.19 0.73
253_G 290_Y 1.188 0.73
66_P 75_T 1.183 0.72
162_D 183_H 1.173 0.72
42_E 85_E 1.172 0.71
120_G 296_V 1.162 0.70
143_H 153_S 1.162 0.70
106_M 153_S 1.156 0.70
7_V 48_Y 1.154 0.70
143_H 252_L 1.152 0.70
242_G 284_K 1.144 0.69
181_I 197_N 1.141 0.68
190_L 240_I 1.136 0.68
104_V 134_G 1.135 0.68
13_T 192_G 1.129 0.67
147_V 152_V 1.129 0.67
168_E 175_E 1.128 0.67
6_L 19_L 1.125 0.67
41_L 44_V 1.12 0.66
17_L 45_I 1.114 0.66
246_G 285_G 1.114 0.66
7_V 309_S 1.109 0.65
63_I 259_F 1.109 0.65
249_A 281_F 1.108 0.65
11_G 137_T 1.108 0.65
65_C 81_F 1.107 0.65
13_T 263_G 1.107 0.65
186_A 244_F 1.104 0.65
112_K 115_H 1.092 0.64
239_V 276_G 1.09 0.63
143_H 154_L 1.088 0.63
65_C 95_L 1.086 0.63
165_P 174_L 1.086 0.63
33_Y 51_E 1.084 0.63
306_L 309_S 1.081 0.62
195_L 214_K 1.08 0.62
45_I 61_I 1.073 0.62
104_V 304_P 1.07 0.61
242_G 280_A 1.069 0.61
76_N 137_T 1.067 0.61
137_T 263_G 1.067 0.61
105_S 142_A 1.065 0.61
14_N 44_V 1.062 0.60
118_Q 121_G 1.061 0.60
190_L 241_M 1.056 0.60
76_N 192_G 1.055 0.60
117_I 273_K 1.053 0.59
182_G 283_D 1.051 0.59
242_G 275_S 1.05 0.59
8_G 17_L 1.048 0.59
227_C 230_C 1.046 0.59
108_I 268_F 1.045 0.58
11_G 192_G 1.045 0.58
235_S 271_F 1.041 0.58
299_I 311_A 1.011 0.55
7_V 28_S 1.011 0.55
163_F 198_L 1.008 0.54
218_I 233_A 1.008 0.54
70_D 139_L 1.008 0.54
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1sz2A211000.537Contact Map0.682
3vpzA10.99381000.54Contact Map0.574
2q2rA20.95951000.588Contact Map0.521
3vglA10.9191000.708Contact Map0.465
2qm1A40.91591000.711Contact Map0.507
2ap1A10.90341000.712Contact Map0.432
2aa4A20.86291000.717Contact Map0.475
4db3A10.90031000.717Contact Map0.474
3mcpA10.90651000.719Contact Map0.34
4htlA10.88161000.72Contact Map0.412
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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