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OPENSEQ.org

GLPE - Thiosulfate sulfurtransferase GlpE
UniProt: P0A6V5 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10395
Length: 108 (102)
Sequences: 5500
Seq/Len: 53.92

GLPE
Paralog alert: 0.82 [within 20: 0.14] - ratio of genomes with paralogs
Cluster includes: GLPE PSPE YIBN
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
32_F 36_H 3.542 1.00
51_F 54_D 2.63 1.00
32_F 42_H 2.625 1.00
31_S 70_S 2.22 1.00
13_H 17_Q 2.131 1.00
29_P 33_A 2.073 1.00
8_N 11_D 2.031 1.00
62_M 89_I 2.005 1.00
28_D 46_D 1.999 1.00
66_Y 94_E 1.941 1.00
64_M 93_F 1.867 1.00
45_N 74_A 1.807 1.00
63_V 78_L 1.805 1.00
71_S 88_S 1.711 1.00
77_Y 81_Q 1.698 1.00
6_C 90_D 1.69 1.00
60_P 85_V 1.625 1.00
29_P 42_H 1.56 1.00
22_V 41_F 1.548 1.00
24_V 63_V 1.525 1.00
12_A 62_M 1.497 1.00
57_F 83_Y 1.469 1.00
36_H 64_M 1.452 1.00
49_G 77_Y 1.449 1.00
6_C 88_S 1.442 1.00
60_P 87_Y 1.428 1.00
12_A 89_I 1.419 1.00
75_A 86_V 1.419 1.00
37_A 64_M 1.395 0.99
91_G 95_A 1.36 0.99
22_V 59_T 1.337 0.99
48_L 74_A 1.326 0.99
15_K 60_P 1.3 0.99
32_F 40_A 1.293 0.99
93_F 102_A 1.283 0.99
35_G 93_F 1.275 0.99
64_M 89_I 1.272 0.99
11_D 14_Q 1.264 0.99
69_N 73_G 1.233 0.98
23_L 64_M 1.226 0.98
9_V 95_A 1.193 0.98
35_G 97_Q 1.19 0.98
22_V 56_D 1.181 0.98
55_N 61_V 1.178 0.98
47_T 51_F 1.156 0.97
21_A 62_M 1.138 0.97
22_V 61_V 1.133 0.97
43_L 51_F 1.093 0.96
14_Q 18_E 1.048 0.94
4_F 79_L 1.026 0.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1gmxA1199.90.129Contact Map0.666
1yt8A1199.90.157Contact Map0.709
3tp9A20.96399.90.159Contact Map0.827
1qxnA2199.90.163Contact Map0.616
3emeA10.935299.90.17Contact Map0.718
3gk5A10.96399.90.175Contact Map0.765
3fojA10.907499.90.175Contact Map0.725
3icsA20.944499.90.177Contact Map0.827
1tq1A10.953799.90.182Contact Map0.303
2hhgA1199.90.184Contact Map0.725

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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