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OPENSEQ.org
GLGC - Glucose-1-phosphate adenylyltransferase
UniProt: P0A6V1 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10379
Length: 431 (406)
Sequences: 2859
Seq/Len: 7.04
GLGC
Paralog alert: 0.37 [within 20: 0.13] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
379_L 382_C 4.441 1.00
154_I 158_E 3.953 1.00
345_V 348_S 3.752 1.00
362_I 365_A 3.511 1.00
367_L 373_V 3.451 1.00
156_H 164_T 3.43 1.00
363_D 380_R 3.358 1.00
358_S 375_R 3.054 1.00
357_N 375_R 2.94 1.00
360_C 377_C 2.859 1.00
184_D 188_K 2.846 1.00
350_L 356_V 2.818 1.00
374_G 392_E 2.773 1.00
384_I 390_I 2.743 1.00
346_V 363_D 2.681 1.00
384_I 388_C 2.67 1.00
347_Q 364_S 2.666 1.00
169_P 258_P 2.624 1.00
353_R 370_E 2.574 1.00
22_A 66_I 2.573 1.00
364_S 381_R 2.551 1.00
153_L 217_V 2.476 1.00
162_R 219_D 2.441 1.00
375_R 392_E 2.377 1.00
152_M 166_A 2.264 1.00
182_A 208_K 2.221 1.00
135_Y 157_V 2.209 1.00
169_P 209_S 2.198 1.00
365_A 379_L 2.193 1.00
155_D 159_K 2.179 1.00
344_V 361_N 2.168 1.00
22_A 61_C 2.098 1.00
152_M 217_V 2.064 1.00
58_L 69_M 2.062 1.00
372_W 389_V 2.052 1.00
225_E 229_E 2.032 1.00
359_F 376_S 2.019 1.00
230_D 236_S 1.972 1.00
161_A 255_Y 1.969 1.00
365_A 382_C 1.943 1.00
159_K 255_Y 1.934 1.00
348_S 362_I 1.922 1.00
367_L 371_V 1.905 1.00
377_C 394_M 1.815 1.00
351_F 369_P 1.807 1.00
19_K 134_E 1.805 1.00
229_E 251_A 1.803 1.00
167_C 256_A 1.789 1.00
378_R 395_V 1.757 1.00
220_A 224_Y 1.751 1.00
352_S 369_P 1.737 1.00
135_Y 219_D 1.708 1.00
331_N 347_Q 1.704 1.00
179_G 194_E 1.686 1.00
371_V 388_C 1.677 1.00
137_V 217_V 1.676 1.00
184_D 190_I 1.671 1.00
402_E 405_R 1.643 1.00
189_I 256_A 1.643 1.00
30_G 42_K 1.626 1.00
139_L 149_Y 1.619 1.00
349_V 366_V 1.616 1.00
165_V 189_I 1.612 1.00
338_C 350_L 1.604 1.00
125_L 228_E 1.6 1.00
361_N 378_R 1.594 1.00
115_R 119_D 1.588 1.00
182_A 193_V 1.571 1.00
61_C 139_L 1.565 1.00
379_L 384_I 1.549 1.00
370_E 387_A 1.54 0.99
363_D 378_R 1.523 0.99
330_L 346_V 1.521 0.99
182_A 191_E 1.498 0.99
193_V 200_P 1.492 0.99
355_R 372_W 1.487 0.99
340_I 343_S 1.483 0.99
136_V 220_A 1.475 0.99
172_I 209_S 1.462 0.99
155_D 257_H 1.457 0.99
40_R 79_T 1.454 0.99
55_D 83_H 1.448 0.99
32_R 42_K 1.446 0.99
345_V 350_L 1.436 0.99
362_I 367_L 1.424 0.99
376_S 393_G 1.405 0.99
79_T 82_Q 1.398 0.99
71_V 84_I 1.391 0.99
341_S 358_S 1.389 0.99
359_F 375_R 1.381 0.99
354_V 386_R 1.378 0.99
68_R 97_E 1.376 0.99
322_R 338_C 1.376 0.99
369_P 386_R 1.374 0.99
188_K 255_Y 1.37 0.99
55_D 59_S 1.369 0.99
357_N 374_G 1.367 0.98
152_M 164_T 1.363 0.98
357_N 360_C 1.359 0.98
125_L 224_Y 1.354 0.98
400_A 404_A 1.352 0.98
24_I 61_C 1.341 0.98
371_V 384_I 1.329 0.98
46_H 51_F 1.329 0.98
334_V 345_V 1.325 0.98
188_K 253_L 1.319 0.98
163_C 248_I 1.298 0.98
336_G 352_S 1.296 0.98
66_I 153_L 1.294 0.98
377_C 392_E 1.291 0.98
273_Y 289_D 1.287 0.98
205_D 208_K 1.28 0.97
84_I 99_V 1.271 0.97
138_I 218_F 1.258 0.97
172_I 201_S 1.257 0.97
129_R 224_Y 1.249 0.97
339_V 355_R 1.245 0.97
337_G 353_R 1.239 0.97
366_V 383_V 1.236 0.97
40_R 46_H 1.233 0.97
237_S 243_D 1.224 0.96
151_R 154_I 1.223 0.96
368_L 383_V 1.215 0.96
350_L 354_V 1.214 0.96
128_I 223_L 1.214 0.96
191_E 201_S 1.214 0.96
317_K 339_V 1.198 0.96
28_G 32_R 1.198 0.96
50_K 59_S 1.197 0.96
54_I 71_V 1.192 0.96
335_S 352_S 1.191 0.96
180_V 211_A 1.188 0.95
374_G 389_V 1.186 0.95
25_L 28_G 1.181 0.95
163_C 245_I 1.173 0.95
189_I 254_A 1.17 0.95
54_I 84_I 1.163 0.95
167_C 181_M 1.161 0.95
371_V 385_D 1.16 0.95
328_M 344_V 1.157 0.95
134_E 219_D 1.153 0.94
163_C 254_A 1.147 0.94
338_C 354_V 1.142 0.94
249_T 254_A 1.139 0.94
396_I 415_V 1.124 0.93
60_N 64_S 1.123 0.93
399_N 402_E 1.121 0.93
162_R 253_L 1.121 0.93
167_C 210_L 1.12 0.93
129_R 228_E 1.12 0.93
27_G 30_G 1.113 0.93
377_C 390_I 1.112 0.93
360_C 392_E 1.11 0.93
233_D 243_D 1.106 0.93
42_K 142_D 1.099 0.92
378_R 398_E 1.096 0.92
122_T 228_E 1.095 0.92
19_K 157_V 1.095 0.92
51_F 55_D 1.093 0.92
221_D 225_E 1.092 0.92
395_V 398_E 1.091 0.92
335_S 338_C 1.076 0.91
151_R 155_D 1.065 0.91
25_L 120_A 1.062 0.91
237_S 242_K 1.062 0.91
54_I 80_L 1.06 0.90
357_N 372_W 1.06 0.90
140_A 143_H 1.055 0.90
162_R 222_Y 1.044 0.90
32_R 43_P 1.043 0.90
155_D 255_Y 1.042 0.89
174_E 177_A 1.041 0.89
21_V 128_I 1.035 0.89
247_K 251_A 1.032 0.89
283_Y 368_L 1.031 0.89
134_E 221_D 1.03 0.89
183_V 210_L 1.03 0.89
187_D 258_P 1.03 0.89
193_V 198_N 1.028 0.89
183_V 256_A 1.025 0.88
382_C 396_I 1.025 0.88
354_V 369_P 1.023 0.88
70_G 102_L 1.022 0.88
343_S 360_C 1.02 0.88
27_G 33_L 1.018 0.88
226_L 251_A 1.017 0.88
404_A 409_R 1.015 0.88
345_V 362_I 1.014 0.88
30_G 43_P 1.014 0.88
354_V 371_V 1 0.87
28_G 179_G 1 0.87
360_C 376_S 1 0.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3brkX10.97451000.41Contact Map0.775
1yp2A40.94431000.458Contact Map0.824
2ggoA10.83061000.524Contact Map0.764
4g3qA10.90491000.55Contact Map0.721
3st8A10.90491000.55Contact Map0.728
1hm9A20.8841000.552Contact Map0.705
2v0hA10.86081000.571Contact Map0.719
4fceA10.87241000.572Contact Map0.712
3jukA40.5941000.634Contact Map0.723
2e3dA40.62651000.646Contact Map0.766
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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