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OPENSEQ.org
FIS - DNA-binding protein fis
UniProt: P0A6R3 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10317
Length: 98 (96)
Sequences: 184
Seq/Len: 1.92
FIS
Paralog alert: 0.00 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
55_L 67_M 1.73 0.96
62_L 83_I 1.518 0.91
27_L 31_V 1.438 0.88
63_L 84_N 1.421 0.87
67_M 92_L 1.415 0.87
2_F 5_R 1.357 0.83
11_L 17_N 1.351 0.83
14_S 17_N 1.333 0.82
71_R 75_T 1.322 0.81
50_L 72_G 1.32 0.81
39_F 42_L 1.304 0.80
24_Q 45_Q 1.297 0.80
63_L 91_K 1.293 0.79
30_S 58_V 1.287 0.79
28_R 57_E 1.277 0.78
70_T 93_K 1.259 0.77
11_L 14_S 1.258 0.77
41_Q 86_G 1.239 0.75
74_Q 91_K 1.22 0.73
27_L 40_A 1.214 0.73
76_R 83_I 1.201 0.72
57_E 67_M 1.175 0.69
28_R 86_G 1.165 0.68
29_D 75_T 1.164 0.68
31_V 55_L 1.161 0.68
5_R 9_D 1.14 0.66
12_T 18_S 1.139 0.66
64_D 70_T 1.129 0.65
36_K 39_F 1.125 0.64
8_S 16_V 1.123 0.64
63_L 76_R 1.123 0.64
10_V 13_V 1.114 0.63
29_D 58_V 1.104 0.62
55_L 69_Y 1.096 0.61
50_L 54_V 1.079 0.60
31_V 57_E 1.075 0.59
63_L 92_L 1.073 0.59
67_M 72_G 1.072 0.59
92_L 97_M 1.07 0.59
65_M 95_Y 1.06 0.58
17_N 20_D 1.054 0.57
28_R 75_T 1.049 0.56
51_Y 55_L 1.044 0.56
46_D 76_R 1.041 0.56
8_S 12_T 1.034 0.55
8_S 15_T 1.031 0.54
31_V 34_A 1.029 0.54
36_K 65_M 1.023 0.54
26_P 50_L 1.022 0.54
10_V 14_S 1.022 0.54
8_S 13_V 1.018 0.53
5_R 13_V 1.016 0.53
56_A 93_K 1.015 0.53
41_Q 70_T 1.014 0.53
25_K 43_N 1.011 0.52
2_F 16_V 1.007 0.52
2_F 11_L 1.006 0.52
39_F 53_L 1.004 0.52
13_V 17_N 1.002 0.51
15_T 20_D 1 0.51
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1etoA2199.90.427Contact Map0.257
1ntcA20.8776990.695Contact Map0.06
4l4uA10.989898.90.701Contact Map0.609
3e7lA40.60298.80.71Contact Map0.259
2m8gX10.673598.70.721Contact Map0.292
1umqA10.765398.70.727Contact Map0.218
1g2hA10.612298.60.733Contact Map0.189
1ojlA60.938898.50.744Contact Map0.215
4l5eA10.469497.90.781Contact Map0.271
1hqcA20.979697.10.812Contact Map0.057
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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