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NANA - N-acetylneuraminate lyase
UniProt: P0A6L4 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10637
Length: 297 (289)
Sequences: 4518
Seq/Len: 15.63

NANA
Paralog alert: 0.62 [within 20: 0.03] - ratio of genomes with paralogs
Cluster includes: DAPA NANA YAGE YJHH
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
228_D 231_T 4.396 1.00
17_D 21_A 3.457 1.00
32_Q 69_E 3.233 1.00
119_C 154_T 3.083 1.00
96_K 131_G 3 1.00
24_K 61_Q 2.846 1.00
80_V 92_A 2.826 1.00
261_Y 286_K 2.75 1.00
28_R 69_E 2.682 1.00
223_A 231_T 2.619 1.00
24_K 65_I 2.618 1.00
197_G 202_A 2.543 1.00
28_R 65_I 2.43 1.00
32_Q 73_K 2.32 1.00
231_T 234_K 2.261 1.00
92_A 103_V 2.24 1.00
60_E 94_S 2.172 1.00
115_F 151_Q 2.124 1.00
222_K 226_E 2.121 1.00
223_A 228_D 2.111 1.00
9_M 41_G 2.104 1.00
116_E 120_D 2.085 1.00
28_R 68_E 2.068 1.00
10_A 210_Y 2.019 1.00
32_Q 36_Q 2.016 1.00
40_D 222_K 2.015 1.00
146_K 173_Q 2.014 1.00
127_D 158_L 1.988 1.00
61_Q 64_E 1.963 1.00
119_C 123_R 1.915 1.00
116_E 154_T 1.904 1.00
123_R 127_D 1.885 1.00
33_F 37_Q 1.872 1.00
64_E 68_E 1.87 1.00
85_T 121_H 1.867 1.00
152_I 164_L 1.857 1.00
198_L 224_L 1.848 1.00
135_V 163_A 1.847 1.00
31_V 66_V 1.846 1.00
123_R 158_L 1.825 1.00
153_N 180_E 1.771 1.00
23_D 26_S 1.737 1.00
135_V 206_I 1.731 1.00
234_K 238_E 1.712 1.00
67_A 76_L 1.704 1.00
218_Q 222_K 1.703 1.00
61_Q 65_I 1.696 1.00
216_R 238_E 1.696 1.00
126_I 158_L 1.69 1.00
37_Q 215_W 1.679 1.00
56_L 87_E 1.666 1.00
26_S 29_R 1.659 1.00
148_T 151_Q 1.65 1.00
283_P 286_K 1.635 1.00
58_E 271_R 1.635 1.00
286_K 290_Q 1.612 1.00
89_Q 124_A 1.61 1.00
105_A 125_I 1.584 1.00
27_L 66_V 1.572 1.00
27_L 62_V 1.559 1.00
129_A 132_L 1.558 1.00
120_D 123_R 1.558 1.00
115_F 148_T 1.538 1.00
35_I 73_K 1.475 1.00
257_T 282_L 1.475 1.00
155_L 161_V 1.456 1.00
283_P 287_A 1.451 1.00
15_P 27_L 1.451 1.00
13_L 259_L 1.443 1.00
103_V 129_A 1.436 1.00
63_L 78_A 1.429 1.00
88_S 125_I 1.425 1.00
9_M 43_Y 1.416 1.00
93_A 97_R 1.405 0.99
219_G 223_A 1.389 0.99
96_K 129_A 1.379 0.99
92_A 129_A 1.377 0.99
120_D 124_A 1.373 0.99
44_V 66_V 1.354 0.99
65_I 68_E 1.345 0.99
35_I 74_I 1.341 0.99
31_V 70_A 1.34 0.99
178_R 186_L 1.333 0.99
31_V 69_E 1.327 0.99
260_H 267_V 1.326 0.99
65_I 69_E 1.319 0.99
82_C 88_S 1.312 0.99
279_E 282_L 1.295 0.99
219_G 222_K 1.284 0.99
40_D 218_Q 1.278 0.99
8_V 39_I 1.27 0.99
60_E 90_Q 1.264 0.99
57_S 61_Q 1.244 0.98
50_E 256_K 1.226 0.98
56_L 94_S 1.225 0.98
124_A 272_K 1.201 0.98
224_L 229_I 1.199 0.98
257_T 261_Y 1.193 0.98
77_I 135_V 1.189 0.98
26_S 266_S 1.188 0.98
195_A 232_A 1.178 0.98
279_E 283_P 1.171 0.98
229_I 233_Q 1.167 0.97
70_A 76_L 1.158 0.97
260_H 265_V 1.149 0.97
77_I 102_A 1.147 0.97
230_Q 233_Q 1.143 0.97
89_Q 93_A 1.14 0.97
287_A 291_Q 1.128 0.97
43_Y 104_S 1.125 0.97
60_E 64_E 1.125 0.97
6_R 225_K 1.125 0.97
63_L 95_A 1.124 0.97
21_A 86_A 1.116 0.96
278_D 281_Y 1.111 0.96
80_V 95_A 1.105 0.96
56_L 90_Q 1.105 0.96
67_A 101_D 1.1 0.96
28_R 32_Q 1.091 0.96
103_V 134_M 1.084 0.96
174_M 197_G 1.08 0.95
107_T 147_L 1.075 0.95
84_S 87_E 1.074 0.95
60_E 97_R 1.068 0.95
219_G 231_T 1.067 0.95
154_T 157_T 1.055 0.95
284_E 287_A 1.053 0.95
94_S 97_R 1.049 0.94
10_A 39_I 1.046 0.94
45_G 62_V 1.045 0.94
80_V 103_V 1.035 0.94
124_A 128_S 1.031 0.94
176_Q 180_E 1.031 0.94
56_L 91_L 1.029 0.94
103_V 132_L 1.024 0.93
257_T 286_K 1.022 0.93
96_K 132_L 1.019 0.93
30_L 259_L 1.015 0.93
116_E 119_C 1.015 0.93
33_F 264_V 1.01 0.93
126_I 161_V 1.01 0.93
196_S 199_L 1.002 0.92
277_V 285_L 1.001 0.92
259_L 262_M 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3na8A40.98651000.039Contact Map0.797
3eb2A40.99331000.041Contact Map0.756
2wkjA40.99661000.047Contact Map0.823
1xkyA40.97981000.05Contact Map0.852
3qzeA40.98991000.05Contact Map0.841
3si9A40.99331000.05Contact Map0.835
4ahqA40.98321000.051Contact Map0.771
2v9dA40.99331000.052Contact Map0.769
4fhaA20.98991000.053Contact Map0.77
3fluA40.98651000.054Contact Map0.844

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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