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OPENSEQ.org
DEOC - Deoxyribose-phosphate aldolase
UniProt: P0A6L0 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10221
Length: 259 (239)
Sequences: 1450
Seq/Len: 6.07
DEOC
Paralog alert: 0.13 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
208_T 211_D 4.385 1.00
119_F 160_K 3.188 1.00
115_E 153_K 3.153 1.00
126_K 136_L 3.063 1.00
111_M 149_A 3.014 1.00
114_N 117_V 2.981 1.00
144_E 173_V 2.848 1.00
92_A 96_Y 2.819 1.00
159_I 198_V 2.687 1.00
110_L 115_E 2.499 1.00
14_L 216_L 2.498 1.00
119_F 123_K 2.312 1.00
151_I 181_S 2.295 1.00
83_I 87_L 2.264 1.00
109_A 117_V 2.24 1.00
179_P 214_K 2.198 1.00
109_A 114_N 2.172 1.00
183_R 187_E 2.14 1.00
45_A 71_A 2.138 1.00
121_L 125_C 2.087 1.00
26_D 112_A 2.08 1.00
103_V 122_V 2.059 1.00
105_F 110_L 2.036 1.00
19_T 29_V 2.029 1.00
153_K 156_E 1.921 1.00
152_R 188_V 1.895 1.00
123_K 127_E 1.891 1.00
30_I 55_I 1.848 1.00
90_T 101_V 1.847 1.00
82_D 92_A 1.813 1.00
19_T 24_D 1.808 1.00
90_T 129_C 1.785 1.00
69_R 99_D 1.777 1.00
207_R 211_D 1.775 1.00
84_D 92_A 1.764 1.00
57_R 99_D 1.754 1.00
30_I 59_T 1.728 1.00
92_A 95_A 1.708 1.00
82_D 96_Y 1.677 1.00
213_Q 217_A 1.67 1.00
138_V 163_A 1.664 1.00
91_R 95_A 1.658 1.00
143_G 174_A 1.626 1.00
49_Y 78_H 1.621 1.00
212_A 235_F 1.59 0.99
50_P 72_T 1.567 0.99
129_C 136_L 1.558 0.99
110_L 157_I 1.545 0.99
34_H 59_T 1.545 0.99
34_H 40_V 1.539 0.99
49_Y 80_N 1.527 0.99
53_I 70_I 1.51 0.99
186_M 199_G 1.495 0.99
209_A 213_Q 1.455 0.99
186_M 196_K 1.45 0.99
15_M 240_L 1.422 0.98
147_D 180_E 1.406 0.98
99_D 134_V 1.389 0.98
143_G 173_V 1.389 0.98
30_I 34_H 1.387 0.98
44_A 69_R 1.381 0.98
119_F 157_I 1.377 0.98
19_T 28_K 1.37 0.98
146_K 149_A 1.363 0.98
50_P 81_D 1.362 0.98
13_K 67_E 1.354 0.98
155_S 185_M 1.353 0.98
140_I 151_I 1.344 0.98
55_I 59_T 1.338 0.98
54_P 96_Y 1.327 0.97
211_D 214_K 1.323 0.97
56_A 70_I 1.321 0.97
142_T 203_A 1.32 0.97
110_L 154_A 1.317 0.97
81_D 85_I 1.317 0.97
182_A 200_F 1.304 0.97
140_I 166_I 1.289 0.97
155_S 189_I 1.285 0.97
211_D 215_Y 1.285 0.97
159_I 195_E 1.281 0.97
179_P 218_I 1.268 0.96
43_T 240_L 1.266 0.96
135_L 164_D 1.261 0.96
159_I 197_T 1.254 0.96
118_G 121_L 1.25 0.96
105_F 154_A 1.242 0.96
175_V 178_T 1.239 0.96
26_D 52_F 1.239 0.96
85_I 88_A 1.237 0.96
147_D 151_I 1.225 0.95
94_I 128_A 1.212 0.95
26_D 55_I 1.196 0.94
126_K 130_A 1.192 0.94
210_E 214_K 1.189 0.94
12_L 42_N 1.181 0.94
83_I 121_L 1.169 0.93
155_S 166_I 1.169 0.93
51_R 106_P 1.166 0.93
54_P 58_K 1.162 0.93
23_D 144_E 1.131 0.92
220_D 232_H 1.115 0.91
140_I 154_A 1.103 0.90
47_C 73_V 1.098 0.90
210_E 213_Q 1.091 0.90
103_V 125_C 1.089 0.90
18_T 32_L 1.088 0.90
158_S 161_A 1.086 0.90
74_T 101_V 1.085 0.90
57_R 70_I 1.079 0.89
214_K 218_I 1.077 0.89
27_E 30_I 1.076 0.89
42_N 67_E 1.069 0.89
152_R 187_E 1.066 0.88
47_C 71_A 1.057 0.88
179_P 215_Y 1.048 0.87
94_I 134_V 1.048 0.87
189_I 200_F 1.046 0.87
78_H 172_K 1.041 0.87
126_K 164_D 1.041 0.87
61_K 64_G 1.038 0.87
199_G 226_D 1.031 0.86
169_S 176_N 1.026 0.86
166_I 185_M 1.013 0.85
207_R 239_S 1.009 0.84
28_K 31_A 1.003 0.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1p1xA20.98841000.182Contact Map0.728
4eivA20.9731000.182Contact Map0.55
2a4aA20.95751000.186Contact Map0.687
1vcvA20.8341000.282Contact Map0.692
3oa3A20.91511000.296Contact Map0.744
3r12A20.88031000.301Contact Map0.865
3ngjA40.8611000.325Contact Map0.849
3ndoA20.85711000.355Contact Map0.705
1ub3A40.84941000.399Contact Map0.769
1n7kA20.85711000.438Contact Map0.674
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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