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OPENSEQ.org
CLPX - ATP-dependent Clp protease ATP-binding subunit ClpX
UniProt: P0A6H1 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10159
Length: 424 (409)
Sequences: 1352
Seq/Len: 3.31
CLPX
Paralog alert: 0.05 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
319_E 360_K 6.467 1.00
324_Q 328_E 5.446 1.00
162_I 238_V 4.813 1.00
319_E 356_D 4.676 1.00
400_E 404_D 4.165 1.00
318_S 321_A 4.101 1.00
71_R 75_D 4.077 1.00
349_E 395_K 3.843 1.00
379_A 403_I 3.582 1.00
347_D 395_K 3.505 1.00
353_E 400_E 3.461 1.00
361_K 364_A 3.133 1.00
177_Q 239_D 2.882 1.00
174_Q 177_Q 2.668 1.00
320_E 356_D 2.537 1.00
88_L 128_L 2.46 1.00
351_R 399_D 2.434 1.00
111_G 130_E 2.429 1.00
166_L 238_V 2.424 1.00
26_R 38_D 2.396 1.00
68_H 386_D 2.225 1.00
254_L 290_V 2.198 1.00
339_A 342_N 2.196 1.00
357_A 360_K 2.142 1.00
327_K 352_D 2.137 1.00
73_H 135_L 2.132 1.00
334_T 355_L 2.093 1.00
357_A 404_D 2.067 1.00
162_I 181_V 1.987 1.00
390_M 393_V 1.91 1.00
166_L 173_V 1.893 1.00
247_C 308_L 1.884 0.99
356_D 360_K 1.862 0.99
346_V 387_L 1.845 0.99
70_I 135_L 1.785 0.99
71_R 82_E 1.769 0.99
13_L 28_L 1.748 0.99
256_K 259_S 1.729 0.99
392_D 413_Y 1.691 0.99
352_D 356_D 1.664 0.98
117_L 312_A 1.642 0.98
141_T 181_V 1.635 0.98
29_I 41_V 1.621 0.98
338_Q 347_D 1.602 0.98
13_L 22_Q 1.599 0.98
72_N 75_D 1.57 0.97
158_V 210_A 1.561 0.97
47_I 51_E 1.541 0.97
390_M 413_Y 1.531 0.97
358_I 376_V 1.519 0.97
156_E 196_P 1.506 0.97
20_K 39_E 1.499 0.96
191_R 196_P 1.483 0.96
22_Q 30_A 1.478 0.96
222_V 238_V 1.455 0.96
286_L 289_Q 1.43 0.95
169_C 214_L 1.408 0.94
319_E 323_I 1.387 0.94
401_S 406_Q 1.387 0.94
30_A 35_Y 1.378 0.94
30_A 47_I 1.376 0.93
72_N 76_D 1.358 0.93
137_D 175_K 1.348 0.93
221_A 235_F 1.34 0.92
321_A 324_Q 1.34 0.92
86_K 382_D 1.329 0.92
342_N 347_D 1.324 0.92
341_F 380_L 1.322 0.92
360_K 400_E 1.321 0.92
224_P 233_Q 1.314 0.91
225_Q 234_E 1.308 0.91
123_S 314_L 1.298 0.91
361_K 378_A 1.296 0.90
109_E 134_R 1.294 0.90
71_R 385_Y 1.285 0.90
116_L 254_L 1.269 0.89
312_A 316_E 1.267 0.89
401_S 405_G 1.259 0.89
300_L 304_F 1.234 0.87
22_Q 43_L 1.228 0.87
357_A 403_I 1.224 0.87
160_N 163_Q 1.221 0.87
30_A 51_E 1.214 0.86
305_I 361_K 1.205 0.86
323_I 356_D 1.192 0.85
358_I 379_A 1.19 0.85
334_T 376_V 1.188 0.85
267_G 272_A 1.186 0.84
29_I 47_I 1.179 0.84
383_T 398_I 1.178 0.84
72_N 385_Y 1.172 0.83
94_N 384_M 1.172 0.83
387_L 396_V 1.17 0.83
350_F 399_D 1.166 0.83
106_N 339_A 1.163 0.83
35_Y 49_R 1.161 0.83
86_K 385_Y 1.151 0.82
14_Y 24_E 1.146 0.81
364_A 406_Q 1.142 0.81
71_R 89_A 1.141 0.81
402_V 409_P 1.128 0.80
290_V 311_V 1.126 0.80
47_I 50_E 1.123 0.80
32_P 47_I 1.122 0.80
34_V 43_L 1.119 0.79
79_I 324_Q 1.118 0.79
224_P 230_H 1.109 0.78
198_I 230_H 1.107 0.78
350_F 398_I 1.107 0.78
382_D 408_K 1.105 0.78
195_N 198_I 1.102 0.78
320_E 323_I 1.101 0.78
87_V 381_L 1.097 0.77
289_Q 376_V 1.095 0.77
238_V 243_I 1.093 0.77
35_Y 43_L 1.093 0.77
71_R 374_S 1.091 0.77
23_H 35_Y 1.089 0.77
325_I 332_A 1.087 0.77
164_K 221_A 1.085 0.76
215_I 316_E 1.084 0.76
25_V 38_D 1.081 0.76
38_D 47_I 1.077 0.76
53_K 59_R 1.072 0.75
83_Q 288_A 1.068 0.75
351_R 397_V 1.067 0.75
83_Q 381_L 1.057 0.74
224_P 231_P 1.055 0.73
407_S 410_L 1.054 0.73
145_A 183_I 1.054 0.73
386_D 408_K 1.052 0.73
198_I 231_P 1.05 0.73
397_V 410_L 1.048 0.73
22_Q 27_K 1.047 0.73
75_D 85_K 1.042 0.72
20_K 43_L 1.042 0.72
173_V 236_L 1.04 0.72
14_Y 23_H 1.04 0.72
262_V 289_Q 1.038 0.72
228_R 231_P 1.037 0.72
399_D 407_S 1.037 0.72
68_H 72_N 1.035 0.71
333_L 376_V 1.033 0.71
252_A 374_S 1.031 0.71
260_H 297_K 1.03 0.71
78_V 128_L 1.029 0.71
265_G 273_T 1.028 0.71
162_I 166_L 1.025 0.70
66_T 73_H 1.02 0.70
224_P 227_G 1.017 0.69
71_R 380_L 1.016 0.69
198_I 228_R 1.014 0.69
97_K 344_E 1.013 0.69
32_P 35_Y 1.013 0.69
141_T 194_D 1.012 0.69
118_I 290_V 1.011 0.69
99_L 343_L 1.01 0.69
50_E 239_D 1.01 0.69
214_L 238_V 1.007 0.68
68_H 389_S 1.007 0.68
341_F 383_T 1.005 0.68
254_L 287_L 1.001 0.68
166_L 214_L 1 0.68
66_T 391_E 1 0.68
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1g41A10.71231000.677Contact Map0.531
1um8A10.84911000.693Contact Map0.634
3hwsA60.85611000.711Contact Map0.639
1ofhA30.71231000.792Contact Map0.656
1r6bX10.84671000.809Contact Map0.463
3pxiA30.79251000.84Contact Map0.503
1qvrA30.83731000.844Contact Map0.461
4fcwA30.69341000.851Contact Map0.499
4m4wJ60.575599.90.867Contact Map0.343
3sylA20.667599.90.883Contact Map0.432
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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