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OPENSEQ.org
UVRA - UvrABC system protein A
UniProt: P0A698 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11061
Length: 940 (938)
Sequences: 2381
Seq/Len: 2.54
UVRA
Paralog alert: 0.23 [within 20: 0.04] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
279_T 408_S 5.124 1.00
21_I 27_I 5.071 1.00
614_K 629_T 4.952 1.00
590_Q 595_K 4.492 1.00
619_R 674_R 4.29 1.00
784_T 787_E 4.235 1.00
166_L 179_I 3.951 1.00
794_E 814_M 3.867 1.00
10_R 74_D 3.776 1.00
7_R 20_V 3.698 1.00
433_D 481_S 3.535 1.00
742_A 765_Q 3.521 1.00
21_I 558_I 3.487 1.00
340_S 343_V 3.475 1.00
917_V 927_C 3.433 1.00
590_Q 596_R 3.424 1.00
576_P 579_A 3.424 1.00
570_E 585_E 3.365 1.00
556_H 574_E 3.358 1.00
560_I 571_V 3.291 1.00
525_E 935_F 3.278 1.00
341_A 345_K 3.274 1.00
637_C 898_A 3.265 1.00
567_H 794_E 3.221 1.00
628_L 915_I 3.18 1.00
931_H 934_R 3.148 1.00
336_W 344_H 3.13 1.00
105_H 432_S 3.123 1.00
630_L 650_I 3.067 1.00
299_E 337_G 3.039 1.00
635_F 887_V 3.035 1.00
917_V 924_V 3.028 1.00
303_A 333_E 3.026 1.00
630_L 886_V 3.005 1.00
614_K 677_Q 3.003 1.00
27_I 540_T 2.992 1.00
866_A 869_Q 2.978 1.00
612_V 629_T 2.965 1.00
19_L 558_I 2.961 1.00
811_Q 815_D 2.958 1.00
45_L 542_I 2.956 1.00
551_I 557_V 2.937 1.00
783_K 791_M 2.858 1.00
5_E 20_V 2.846 1.00
904_L 915_I 2.833 1.00
267_L 418_A 2.799 1.00
573_A 579_A 2.773 1.00
914_E 929_A 2.767 1.00
616_T 627_T 2.759 1.00
297_N 300_L 2.728 1.00
783_K 799_F 2.683 1.00
630_L 636_T 2.661 1.00
119_R 422_Y 2.65 1.00
468_K 472_N 2.643 1.00
548_E 552_R 2.628 1.00
628_L 902_V 2.566 1.00
178_R 201_E 2.562 1.00
557_V 577_L 2.494 1.00
566_V 822_R 2.484 1.00
438_H 910_S 2.481 1.00
6_V 19_L 2.471 1.00
798_E 801_D 2.462 1.00
125_V 255_I 2.453 1.00
718_V 721_S 2.44 1.00
341_A 344_H 2.439 1.00
573_A 583_V 2.431 1.00
325_A 330_F 2.422 1.00
557_V 580_I 2.397 1.00
791_M 799_F 2.39 1.00
616_T 675_D 2.371 1.00
779_K 784_T 2.362 1.00
636_T 884_T 2.342 1.00
152_A 228_S 2.329 1.00
573_A 580_I 2.326 1.00
6_V 9_A 2.311 1.00
614_K 627_T 2.308 1.00
604_R 922_E 2.29 1.00
29_V 558_I 2.287 1.00
815_D 877_K 2.264 1.00
292_D 298_P 2.242 1.00
624_K 914_E 2.233 1.00
120_C 123_H 2.218 1.00
632_V 682_F 2.197 1.00
349_Y 378_L 2.191 1.00
117_E 452_R 2.185 1.00
3_K 20_V 2.183 1.00
620_G 671_A 2.169 1.00
920_T 923_T 2.168 1.00
221_F 232_A 2.164 1.00
375_E 383_R 2.149 1.00
615_L 618_A 2.142 1.00
412_T 427_P 2.129 1.00
638_I 650_I 2.108 1.00
615_L 630_L 2.106 1.00
444_N 464_G 2.095 1.00
629_T 918_S 2.094 1.00
658_A 853_L 2.088 1.00
577_L 581_M 2.072 1.00
426_T 430_A 2.059 1.00
794_E 819_T 2.059 1.00
449_A 452_R 2.039 1.00
525_E 529_G 2.037 1.00
615_L 673_Y 2.026 0.99
900_W 923_T 2.025 0.99
476_N 911_G 2.022 0.99
616_T 677_Q 2.016 0.99
682_F 853_L 2.015 0.99
639_T 903_D 2.009 0.99
525_E 549_D 2.007 0.99
790_D 822_R 1.991 0.99
15_K 570_E 1.987 0.99
786_H 790_D 1.985 0.99
715_F 788_V 1.973 0.99
427_P 430_A 1.967 0.99
895_I 901_I 1.965 0.99
522_R 907_E 1.963 0.99
120_C 256_C 1.952 0.99
193_E 196_K 1.946 0.99
620_G 672_P 1.915 0.99
797_R 811_Q 1.915 0.99
10_R 72_D 1.895 0.99
177_A 184_C 1.887 0.99
797_R 814_M 1.873 0.99
589_G 593_S 1.869 0.99
431_I 439_A 1.852 0.99
708_F 785_I 1.851 0.99
419_R 427_P 1.803 0.99
298_P 344_H 1.802 0.99
853_L 886_V 1.796 0.98
807_A 811_Q 1.774 0.98
202_V 227_L 1.766 0.98
578_E 582_A 1.762 0.98
169_L 202_V 1.76 0.98
412_T 430_A 1.76 0.98
298_P 337_G 1.76 0.98
156_K 231_T 1.755 0.98
412_T 419_R 1.745 0.98
900_W 918_S 1.742 0.98
148_L 207_F 1.718 0.98
166_L 177_A 1.707 0.98
121_P 260_M 1.707 0.98
331_D 343_V 1.697 0.98
437_G 476_N 1.693 0.98
27_I 558_I 1.693 0.98
657_I 673_Y 1.693 0.98
150_L 234_V 1.682 0.97
177_A 186_L 1.671 0.97
617_G 625_D 1.669 0.97
793_I 821_I 1.659 0.97
730_R 775_T 1.658 0.97
579_A 583_V 1.643 0.97
578_E 584_P 1.643 0.97
178_R 244_E 1.629 0.97
619_R 672_P 1.627 0.97
659_Q 665_A 1.624 0.97
655_F 855_I 1.623 0.97
426_T 434_M 1.62 0.97
860_T 894_V 1.616 0.97
737_G 741_E 1.614 0.96
419_R 429_P 1.612 0.96
626_V 915_I 1.612 0.96
335_P 338_S 1.605 0.96
440_M 444_N 1.604 0.96
615_L 676_I 1.604 0.96
154_I 165_T 1.604 0.96
330_F 343_V 1.604 0.96
412_T 429_P 1.603 0.96
345_K 349_Y 1.603 0.96
139_V 221_F 1.601 0.96
295_I 336_W 1.599 0.96
630_L 638_I 1.598 0.96
532_I 553_A 1.594 0.96
506_V 511_V 1.588 0.96
233_V 244_E 1.579 0.96
288_Y 382_E 1.576 0.96
630_L 902_V 1.576 0.96
116_G 421_V 1.573 0.96
472_N 529_G 1.572 0.96
596_R 866_A 1.571 0.96
334_A 338_S 1.559 0.95
416_R 419_R 1.557 0.95
306_A 336_W 1.553 0.95
652_D 656_P 1.551 0.95
596_R 869_Q 1.548 0.95
408_S 416_R 1.548 0.95
876_H 897_T 1.542 0.95
123_H 256_C 1.539 0.95
112_F 431_I 1.539 0.95
620_G 653_T 1.538 0.95
615_L 654_L 1.538 0.95
112_F 427_P 1.538 0.95
772_N 775_T 1.532 0.95
779_K 787_E 1.528 0.95
907_E 931_H 1.525 0.95
135_M 221_F 1.516 0.94
875_L 887_V 1.514 0.94
117_E 126_P 1.502 0.94
17_I 571_V 1.498 0.94
615_L 653_T 1.493 0.94
17_I 29_V 1.491 0.94
532_I 535_R 1.489 0.94
856_L 875_L 1.483 0.94
140_L 214_T 1.481 0.94
289_F 294_V 1.48 0.94
26_L 541_V 1.479 0.94
289_F 397_L 1.475 0.93
923_T 926_E 1.469 0.93
139_V 209_V 1.469 0.93
925_A 940_L 1.469 0.93
552_R 581_M 1.468 0.93
139_V 234_V 1.466 0.93
338_S 342_N 1.463 0.93
6_V 73_V 1.448 0.93
441_E 445_N 1.448 0.93
122_D 256_C 1.448 0.93
120_C 253_C 1.446 0.92
302_L 332_V 1.443 0.92
426_T 431_I 1.443 0.92
657_I 676_I 1.441 0.92
674_R 677_Q 1.438 0.92
435_S 438_H 1.424 0.92
27_I 542_I 1.424 0.92
347_V 377_V 1.421 0.92
626_V 904_L 1.416 0.91
174_Y 204_V 1.409 0.91
158_R 162_H 1.408 0.91
327_H 354_E 1.4 0.91
26_L 543_V 1.397 0.91
724_R 777_E 1.396 0.91
178_R 235_A 1.393 0.91
324_L 330_F 1.386 0.90
8_G 16_N 1.373 0.90
157_E 274_A 1.373 0.90
876_H 880_D 1.37 0.90
573_A 576_P 1.368 0.89
336_W 347_V 1.361 0.89
157_E 199_T 1.359 0.89
16_N 74_D 1.356 0.89
683_D 849_T 1.35 0.89
295_I 348_L 1.333 0.88
710_P 713_E 1.333 0.88
869_Q 873_D 1.33 0.88
797_R 807_A 1.33 0.88
17_I 560_I 1.329 0.88
655_F 659_Q 1.326 0.87
650_I 654_L 1.319 0.87
917_V 923_T 1.319 0.87
167_E 170_A 1.318 0.87
123_H 258_Y 1.309 0.87
138_N 141_S 1.306 0.86
879_R 885_I 1.303 0.86
170_A 187_S 1.3 0.86
296_Q 308_R 1.298 0.86
142_Q 245_L 1.295 0.86
624_K 910_S 1.295 0.86
926_E 937_K 1.294 0.86
605_V 879_R 1.294 0.86
422_Y 427_P 1.292 0.86
796_A 823_L 1.292 0.86
184_C 190_P 1.291 0.85
150_L 224_A 1.287 0.85
710_P 805_A 1.285 0.85
295_I 344_H 1.284 0.85
303_A 332_V 1.284 0.85
334_A 343_V 1.284 0.85
639_T 895_I 1.282 0.85
709_T 713_E 1.28 0.85
108_L 112_F 1.276 0.85
875_L 885_I 1.276 0.85
843_E 854_Y 1.275 0.85
382_E 386_K 1.274 0.84
301_S 304_G 1.269 0.84
331_D 334_A 1.267 0.84
673_Y 676_I 1.265 0.84
650_I 888_I 1.265 0.84
23_R 506_V 1.259 0.83
110_L 459_I 1.259 0.83
549_D 552_R 1.257 0.83
708_F 771_Y 1.253 0.83
431_I 443_F 1.25 0.83
8_G 74_D 1.244 0.82
253_C 256_C 1.239 0.82
525_E 934_R 1.235 0.82
169_L 186_L 1.23 0.81
552_R 577_L 1.229 0.81
787_E 790_D 1.229 0.81
578_E 581_M 1.229 0.81
179_I 189_P 1.228 0.81
529_G 532_I 1.228 0.81
143_P 146_K 1.227 0.81
45_L 509_M 1.224 0.81
268_F 271_N 1.224 0.81
6_V 542_I 1.224 0.81
720_E 723_A 1.214 0.80
811_Q 814_M 1.211 0.80
528_L 532_I 1.21 0.80
304_G 333_E 1.21 0.80
174_Y 227_L 1.207 0.80
648_T 653_T 1.207 0.80
174_Y 223_T 1.2 0.79
298_P 336_W 1.198 0.79
924_V 933_A 1.196 0.79
10_R 16_N 1.195 0.79
437_G 471_V 1.192 0.79
614_K 675_D 1.192 0.79
573_A 586_S 1.19 0.78
148_L 234_V 1.189 0.78
263_L 421_V 1.188 0.78
769_K 790_D 1.187 0.78
928_E 934_R 1.176 0.77
163_T 191_K 1.173 0.77
441_E 444_N 1.173 0.77
145_G 150_L 1.172 0.77
730_R 772_N 1.169 0.77
528_L 550_A 1.165 0.76
927_C 930_S 1.164 0.76
168_N 172_Q 1.164 0.76
660_R 670_P 1.161 0.76
574_E 580_I 1.16 0.76
322_K 326_D 1.157 0.76
617_G 627_T 1.157 0.76
88_K 93_N 1.157 0.76
648_T 652_D 1.156 0.76
279_T 286_Q 1.153 0.75
907_E 911_G 1.153 0.75
915_I 918_S 1.153 0.75
211_D 214_T 1.15 0.75
328_Y 346_V 1.148 0.75
161_E 191_K 1.146 0.75
123_H 253_C 1.143 0.74
155_I 162_H 1.143 0.74
925_A 933_A 1.142 0.74
148_L 209_V 1.14 0.74
19_L 29_V 1.139 0.74
291_P 349_Y 1.138 0.74
779_K 782_G 1.137 0.74
155_I 158_R 1.134 0.74
619_R 625_D 1.133 0.73
169_L 172_Q 1.132 0.73
617_G 674_R 1.131 0.73
151_L 203_V 1.128 0.73
279_T 407_A 1.127 0.73
625_D 674_R 1.12 0.72
92_H 484_A 1.119 0.72
205_D 216_R 1.114 0.72
706_G 709_T 1.114 0.72
324_L 343_V 1.113 0.72
707_V 806_L 1.11 0.71
607_A 634_L 1.11 0.71
162_H 195_Q 1.109 0.71
162_H 165_T 1.108 0.71
709_T 718_V 1.107 0.71
336_W 339_L 1.104 0.71
310_W 321_L 1.102 0.71
5_E 77_E 1.102 0.71
229_G 250_N 1.101 0.70
178_R 183_V 1.1 0.70
632_V 636_T 1.099 0.70
934_R 938_P 1.098 0.70
438_H 441_E 1.098 0.70
793_I 814_M 1.096 0.70
615_L 656_P 1.09 0.69
472_N 533_H 1.089 0.69
563_G 570_E 1.089 0.69
917_V 925_A 1.087 0.69
235_A 244_E 1.085 0.69
632_V 884_T 1.085 0.69
454_K 457_E 1.083 0.69
627_T 630_L 1.083 0.69
286_Q 407_A 1.082 0.69
380_N 384_R 1.079 0.68
407_A 410_E 1.076 0.68
321_L 332_V 1.074 0.68
579_A 582_A 1.074 0.68
637_C 901_I 1.074 0.68
201_E 233_V 1.072 0.67
638_I 654_L 1.069 0.67
321_L 347_V 1.069 0.67
9_A 73_V 1.068 0.67
440_M 471_V 1.067 0.67
19_L 27_I 1.065 0.67
357_E 369_I 1.065 0.67
809_K 845_S 1.065 0.67
615_L 650_I 1.062 0.66
357_E 371_R 1.061 0.66
579_A 584_P 1.061 0.66
783_K 795_E 1.06 0.66
683_D 851_Q 1.059 0.66
30_T 559_D 1.059 0.66
584_P 589_G 1.057 0.66
176_R 206_R 1.056 0.66
755_F 758_D 1.055 0.66
338_S 341_A 1.052 0.65
362_N 365_G 1.048 0.65
617_G 673_Y 1.048 0.65
124_D 422_Y 1.044 0.64
393_V 397_L 1.042 0.64
303_A 322_K 1.041 0.64
39_S 44_T 1.037 0.64
609_P 634_L 1.037 0.64
620_G 648_T 1.036 0.64
213_L 217_L 1.035 0.63
914_E 918_S 1.035 0.63
599_E 869_Q 1.035 0.63
585_E 590_Q 1.033 0.63
591_Y 596_R 1.032 0.63
579_A 585_E 1.032 0.63
653_T 671_A 1.03 0.63
444_N 468_K 1.03 0.63
450_G 453_A 1.029 0.63
750_K 760_Y 1.026 0.62
137_D 773_R 1.024 0.62
93_N 283_L 1.023 0.62
517_I 888_I 1.022 0.62
769_K 786_H 1.022 0.62
115_V 448_L 1.021 0.62
290_D 402_S 1.018 0.62
415_R 418_A 1.017 0.61
416_R 420_H 1.016 0.61
339_L 344_H 1.016 0.61
397_L 401_I 1.011 0.61
922_E 940_L 1.01 0.61
930_S 933_A 1.007 0.60
294_V 309_G 1.005 0.60
525_E 552_R 1.005 0.60
902_V 915_I 1.003 0.60
295_I 306_A 1.002 0.60
207_F 217_L 1.002 0.60
30_T 551_I 1.001 0.60
872_L 894_V 1.001 0.60
429_P 433_D 1 0.60
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2r6fA20.99471000.233Contact Map0.754
2ygrA60.99791000.246Contact Map0.749
3pihA10.97131000.248Contact Map0.741
2vf7A30.84791000.388Contact Map0.719
3ux8A10.67451000.691Contact Map0.757
4finA20.51491000.87Contact Map0.658
2iw3A20.53621000.871Contact Map0.567
3g5uA20.51381000.872Contact Map0.602
4f4cA10.5161000.875Contact Map0.607
3bk7A10.54471000.879Contact Map0.432
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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