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OPENSEQ.org
GAL7 - Galactose-1-phosphate uridylyltransferase
UniProt: P09148 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10366
Length: 348 (345)
Sequences: 727
Seq/Len: 2.11
GAL7
Paralog alert: 0.05 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
239_A 251_Q 4.024 1.00
216_T 254_D 3.912 1.00
52_C 115_H 3.629 1.00
215_E 238_K 3.523 1.00
195_S 200_D 3.382 1.00
196_P 199_V 3.35 1.00
52_C 55_C 3.206 1.00
333_E 337_A 3.078 1.00
128_T 253_S 2.793 1.00
206_L 220_L 2.765 1.00
55_C 115_H 2.73 1.00
196_P 240_H 2.616 1.00
199_V 240_H 2.404 1.00
109_I 169_I 2.328 1.00
189_Y 200_D 2.311 1.00
172_N 316_Y 2.285 1.00
218_H 254_D 2.279 1.00
214_V 258_A 2.277 1.00
199_V 294_Q 2.264 1.00
261_K 265_R 2.184 1.00
260_K 264_S 2.18 1.00
128_T 132_K 2.16 1.00
182_E 298_H 2.154 1.00
107_R 137_Q 2.138 1.00
242_L 246_D 2.137 1.00
247_L 295_L 2.1 0.99
221_A 262_L 2.077 0.99
220_L 238_K 2.042 0.99
233_T 262_L 2.025 0.99
123_S 126_A 2.025 0.99
132_K 252_R 1.988 0.99
14_Y 19_G 1.961 0.99
196_P 294_Q 1.949 0.99
198_L 236_L 1.853 0.98
127_L 260_K 1.808 0.98
202_V 220_L 1.796 0.98
135_Q 252_R 1.789 0.98
205_E 211_R 1.781 0.98
223_V 227_A 1.78 0.98
216_T 257_L 1.742 0.97
231_F 334_R 1.73 0.97
114_D 117_K 1.714 0.97
280_W 297_A 1.66 0.96
255_L 278_M 1.65 0.96
131_V 134_W 1.648 0.96
240_H 294_Q 1.643 0.96
216_T 258_A 1.631 0.95
326_L 331_A 1.617 0.95
255_L 297_A 1.604 0.95
206_L 212_T 1.573 0.94
219_W 235_L 1.514 0.92
19_G 185_L 1.512 0.92
132_K 253_S 1.51 0.92
218_H 250_A 1.499 0.92
187_K 191_A 1.479 0.91
202_V 206_L 1.468 0.91
243_R 246_D 1.465 0.91
119_L 127_L 1.452 0.90
28_R 31_R 1.448 0.90
85_D 103_R 1.445 0.90
4_F 9_H 1.436 0.89
74_V 133_T 1.433 0.89
48_H 58_N 1.416 0.89
286_N 290_N 1.416 0.89
57_G 68_D 1.416 0.89
225_Y 235_L 1.41 0.88
182_E 281_H 1.403 0.88
147_W 176_P 1.4 0.88
180_E 184_R 1.396 0.88
206_L 238_K 1.389 0.87
137_Q 169_I 1.389 0.87
241_V 247_L 1.38 0.87
111_F 152_E 1.356 0.85
94_D 204_R 1.351 0.85
214_V 261_K 1.351 0.85
219_W 295_L 1.341 0.85
154_K 267_D 1.333 0.84
7_V 328_A 1.316 0.83
12_R 21_W 1.303 0.82
188_E 192_E 1.285 0.81
182_E 293_W 1.281 0.81
231_F 331_A 1.281 0.81
202_V 212_T 1.273 0.80
281_H 298_H 1.271 0.80
316_Y 320_A 1.269 0.80
138_T 282_G 1.261 0.79
277_S 315_G 1.25 0.78
76_T 105_T 1.248 0.78
17_L 198_L 1.223 0.76
19_G 188_E 1.222 0.76
222_V 236_L 1.221 0.76
261_K 340_D 1.219 0.76
5_N 8_D 1.215 0.76
198_L 222_V 1.214 0.76
219_W 280_W 1.201 0.74
263_T 299_F 1.199 0.74
158_M 277_S 1.182 0.73
206_L 215_E 1.171 0.72
280_W 295_L 1.164 0.71
221_A 233_T 1.156 0.70
209_G 215_E 1.145 0.69
142_G 285_F 1.144 0.69
241_V 295_L 1.14 0.69
266_Y 299_F 1.138 0.69
143_K 238_K 1.134 0.68
244_I 255_L 1.134 0.68
20_Q 181_R 1.133 0.68
213_V 233_T 1.131 0.68
122_L 130_I 1.129 0.68
138_T 150_V 1.126 0.67
212_T 220_L 1.124 0.67
121_E 344_R 1.115 0.66
339_S 342_H 1.111 0.66
286_N 291_Q 1.107 0.66
53_F 80_A 1.101 0.65
278_M 297_A 1.087 0.63
97_M 204_R 1.081 0.63
248_T 251_Q 1.071 0.62
75_F 152_E 1.071 0.62
209_G 212_T 1.07 0.62
212_T 222_V 1.058 0.60
271_Q 346_S 1.054 0.60
152_E 165_P 1.052 0.60
112_S 115_H 1.052 0.60
15_N 226_W 1.048 0.59
341_I 346_S 1.045 0.59
18_T 181_R 1.037 0.58
63_G 66_N 1.036 0.58
154_K 273_S 1.036 0.58
328_A 345_E 1.034 0.58
142_G 148_V 1.033 0.58
107_R 169_I 1.031 0.57
132_K 249_D 1.029 0.57
124_V 127_L 1.029 0.57
111_F 130_I 1.029 0.57
135_Q 244_I 1.025 0.57
203_Q 207_A 1.023 0.56
29_A 52_C 1.022 0.56
109_I 112_S 1.022 0.56
202_V 222_V 1.021 0.56
157_A 310_R 1.017 0.56
130_I 263_T 1.012 0.55
327_T 331_A 1.001 0.54
241_V 251_Q 1.001 0.54
43_Q 344_R 1 0.54
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1gupA411000.186Contact Map0.826
1z84A20.9311000.267Contact Map0.756
4i5tA20.770199.90.802Contact Map0.445
3ksvA10.422499.90.806Contact Map0.633
3o0mA20.419599.90.809Contact Map0.569
1y23A50.405299.90.812Contact Map0.711
3l7xA10.488599.90.814Contact Map0.666
3o1cA10.362199.90.814Contact Map0.544
4incA20.373699.90.815Contact Map0.539
3lb5A40.459899.90.816Contact Map0.627
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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