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OPENSEQ.org
DSDX - DsdX permease
UniProt: P08555 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10250
Length: 445 (433)
Sequences: 1311
Seq/Len: 3.03
DSDX
Paralog alert: 0.66 [within 20: 0.04] - ratio of genomes with paralogs
Cluster includes: DSDX GNTP GNTT GNTU IDNT YGBN YJHF
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
20_L 25_F 3.566 1.00
237_L 278_V 3.468 1.00
54_A 324_S 3.039 1.00
92_T 228_L 2.966 1.00
228_L 232_L 2.953 1.00
171_L 390_I 2.888 1.00
14_S 40_V 2.848 1.00
200_F 204_R 2.806 1.00
98_W 195_P 2.728 1.00
17_L 39_F 2.714 1.00
119_E 403_S 2.617 1.00
320_A 324_S 2.52 1.00
440_L 444_I 2.401 1.00
415_T 418_E 2.388 1.00
85_A 231_T 2.341 1.00
436_A 440_L 2.198 1.00
167_V 364_M 2.168 1.00
82_V 297_H 2.151 1.00
347_W 431_S 2.11 1.00
119_E 312_I 2.028 1.00
432_V 436_A 1.988 1.00
329_D 333_V 1.968 1.00
192_I 433_V 1.953 1.00
355_A 397_C 1.952 1.00
118_V 404_L 1.934 0.99
392_S 434_A 1.901 0.99
351_L 396_G 1.893 0.99
14_S 318_F 1.865 0.99
36_A 128_L 1.836 0.99
227_S 230_A 1.819 0.99
344_L 435_L 1.753 0.99
63_L 313_G 1.736 0.99
170_K 368_T 1.732 0.99
425_T 429_I 1.731 0.99
55_I 317_A 1.729 0.99
398_T 402_D 1.676 0.98
397_C 424_T 1.669 0.98
41_G 321_I 1.66 0.98
57_S 61_G 1.65 0.98
156_C 395_I 1.642 0.98
312_I 403_S 1.638 0.98
75_I 298_T 1.625 0.98
281_Y 286_R 1.593 0.97
257_G 261_L 1.588 0.97
40_V 318_F 1.588 0.97
79_M 279_A 1.568 0.97
355_A 396_G 1.566 0.97
20_L 24_K 1.557 0.97
197_F 200_F 1.545 0.97
16_V 20_L 1.528 0.96
31_L 276_V 1.513 0.96
197_F 425_T 1.509 0.96
277_F 281_Y 1.505 0.96
178_V 387_A 1.501 0.96
396_G 431_S 1.467 0.95
122_V 411_Y 1.433 0.94
152_M 427_T 1.433 0.94
333_V 336_S 1.432 0.94
149_T 194_G 1.431 0.94
229_G 233_F 1.426 0.94
154_V 161_H 1.409 0.93
417_N 421_K 1.399 0.93
59_I 67_A 1.387 0.93
185_V 390_I 1.361 0.92
184_L 188_M 1.358 0.92
144_A 412_C 1.355 0.92
121_G 151_L 1.334 0.91
58_G 320_A 1.332 0.91
173_A 178_V 1.328 0.90
10_T 43_M 1.326 0.90
409_K 419_T 1.318 0.90
347_W 435_L 1.317 0.90
419_T 423_Y 1.31 0.90
441_L 444_I 1.29 0.89
28_H 31_L 1.289 0.89
19_V 23_V 1.281 0.88
192_I 196_L 1.279 0.88
278_V 282_V 1.278 0.88
75_I 276_V 1.267 0.88
354_H 402_D 1.263 0.87
33_L 318_F 1.262 0.87
113_G 161_H 1.262 0.87
42_T 48_P 1.259 0.87
241_L 274_I 1.245 0.86
109_G 121_G 1.24 0.86
185_V 441_L 1.234 0.86
78_K 82_V 1.233 0.86
147_L 150_A 1.221 0.85
258_L 261_L 1.221 0.85
39_F 43_M 1.221 0.85
396_G 428_F 1.217 0.85
180_V 184_L 1.217 0.85
331_L 356_A 1.213 0.84
257_G 444_I 1.212 0.84
42_T 274_I 1.206 0.84
91_L 135_K 1.205 0.84
388_I 438_T 1.203 0.84
154_V 164_A 1.202 0.84
98_W 107_L 1.194 0.83
375_L 386_I 1.193 0.83
27_F 32_A 1.191 0.83
17_L 21_T 1.189 0.83
340_M 348_L 1.184 0.82
116_L 148_C 1.178 0.82
68_A 269_I 1.178 0.82
152_M 395_I 1.168 0.81
314_A 317_A 1.168 0.81
155_H 161_H 1.165 0.81
424_T 431_S 1.163 0.81
230_A 282_V 1.162 0.81
163_A 315_G 1.162 0.81
106_V 190_S 1.16 0.80
38_F 270_T 1.159 0.80
112_C 125_L 1.159 0.80
47_G 50_D 1.157 0.80
181_Y 388_I 1.157 0.80
22_I 29_P 1.154 0.80
94_Q 137_N 1.151 0.80
50_D 53_N 1.15 0.80
346_A 388_I 1.15 0.80
290_S 293_T 1.147 0.79
380_D 383_P 1.146 0.79
68_A 72_L 1.144 0.79
54_A 320_A 1.142 0.79
370_I 389_A 1.141 0.79
41_G 51_M 1.137 0.79
56_E 65_F 1.135 0.78
343_I 386_I 1.134 0.78
152_M 360_A 1.131 0.78
201_L 205_L 1.127 0.78
197_F 201_L 1.125 0.78
24_K 111_I 1.124 0.77
438_T 442_S 1.122 0.77
305_I 309_L 1.122 0.77
17_L 36_A 1.122 0.77
36_A 39_F 1.122 0.77
54_A 322_L 1.121 0.77
258_L 262_V 1.118 0.77
254_R 259_Y 1.116 0.77
249_E 444_I 1.116 0.77
19_V 36_A 1.112 0.76
320_A 323_K 1.105 0.76
173_A 387_A 1.105 0.76
88_R 92_T 1.102 0.76
87_E 223_K 1.096 0.75
21_T 27_F 1.095 0.75
397_C 420_F 1.083 0.74
252_M 262_V 1.083 0.74
71_G 310_L 1.083 0.74
319_N 323_K 1.082 0.74
226_P 231_T 1.08 0.73
14_S 39_F 1.076 0.73
185_V 437_G 1.075 0.73
178_V 384_E 1.074 0.73
400_V 411_Y 1.068 0.72
149_T 426_A 1.067 0.72
14_S 44_M 1.065 0.72
440_L 443_F 1.064 0.72
398_T 423_Y 1.059 0.71
200_F 203_Q 1.054 0.71
192_I 429_I 1.052 0.71
76_L 276_V 1.051 0.70
355_A 424_T 1.049 0.70
258_L 440_L 1.047 0.70
188_M 192_I 1.044 0.70
155_H 361_T 1.044 0.70
88_R 228_L 1.037 0.69
157_V 434_A 1.034 0.69
33_L 315_G 1.029 0.68
72_L 272_M 1.025 0.68
227_S 231_T 1.024 0.68
118_V 408_V 1.023 0.68
420_F 424_T 1.02 0.67
402_D 423_Y 1.019 0.67
153_A 430_A 1.017 0.67
94_Q 257_G 1.016 0.67
86_A 159_P 1.015 0.67
222_E 225_L 1.008 0.66
65_F 403_S 1.007 0.66
59_I 68_A 1.006 0.66
32_A 365_M 1.005 0.66
260_I 263_E 1.005 0.66
354_H 363_A 1.003 0.65
115_T 155_H 1.002 0.65
254_R 257_G 1 0.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4f35D40.91011000.759Contact Map0.388
3qnqA40.431520.50.973Contact Map0.469
1b9uA10.07645.10.979Contact Map0.295
2ls4A10.05393.20.981Contact Map0.056
4g1uA20.42922.60.982Contact Map0.209
1wazA10.10342.30.983Contact Map0
1q90G10.08312.20.983Contact Map1
4b19A10.06742.20.983Contact Map0.118
1m56D20.110120.983Contact Map0.379
3aqpA20.35061.90.983Contact Map0.371
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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