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OPENSEQ.org
MURB - UDP-N-acetylenolpyruvoylglucosamine reductase
UniProt: P08373 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11205
Length: 342 (331)
Sequences: 1939
Seq/Len: 5.86
MURB
Paralog alert: 0.05 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
18_Q 59_R 4.123 1.00
315_G 321_W 3.638 1.00
282_A 298_A 3.096 1.00
150_T 153_E 2.902 1.00
13_I 303_V 2.718 1.00
10_T 50_S 2.682 1.00
274_L 313_K 2.574 1.00
114_V 178_L 2.554 1.00
135_Y 177_G 2.543 1.00
267_W 271_Q 2.535 1.00
82_H 177_G 2.482 1.00
129_L 178_L 2.461 1.00
232_K 323_E 2.413 1.00
278_Q 283_A 2.343 1.00
137_D 175_A 2.312 1.00
46_L 52_V 2.276 1.00
26_E 137_D 2.22 1.00
277_M 309_H 2.187 1.00
59_R 331_A 2.182 1.00
281_G 297_N 2.18 1.00
133_C 136_V 2.152 1.00
140_E 145_K 2.139 1.00
309_H 313_K 2.081 1.00
138_S 149_L 2.039 1.00
134_A 179_R 2.021 1.00
266_G 289_A 2.001 1.00
21_V 32_A 1.999 1.00
278_Q 295_E 1.978 1.00
135_Y 148_R 1.974 1.00
274_L 277_M 1.954 1.00
154_C 163_F 1.93 1.00
3_H 8_W 1.904 1.00
146_Q 174_V 1.881 1.00
301_E 305_Q 1.87 1.00
67_I 84_G 1.868 1.00
102_P 183_E 1.845 1.00
275_K 289_A 1.835 1.00
82_H 175_A 1.794 1.00
92_L 114_V 1.794 1.00
281_G 295_E 1.79 1.00
274_L 309_H 1.767 1.00
163_F 173_I 1.76 1.00
224_N 293_I 1.745 1.00
138_S 171_F 1.738 1.00
137_D 148_R 1.736 1.00
36_A 61_T 1.729 1.00
133_C 176_V 1.727 1.00
12_G 225_G 1.706 1.00
9_N 54_F 1.7 1.00
87_E 92_L 1.696 1.00
88_N 91_R 1.69 1.00
133_C 156_F 1.684 1.00
311_R 324_P 1.682 1.00
230_F 292_L 1.682 1.00
272_C 314_V 1.675 1.00
312_Q 316_E 1.668 1.00
283_A 286_R 1.664 1.00
95_Y 99_E 1.661 1.00
44_L 58_Y 1.656 1.00
11_F 227_A 1.641 1.00
80_Y 134_A 1.64 1.00
21_V 61_T 1.637 1.00
284_V 310_V 1.635 1.00
270_D 275_K 1.612 0.99
308_H 311_R 1.607 0.99
44_L 329_I 1.604 0.99
3_H 20_I 1.592 0.99
138_S 147_V 1.568 0.99
281_G 302_D 1.565 0.99
41_Q 61_T 1.545 0.99
283_A 295_E 1.544 0.99
233_N 290_L 1.537 0.99
58_Y 62_V 1.511 0.99
157_G 160_D 1.501 0.99
8_W 20_I 1.498 0.99
123_G 159_R 1.492 0.99
43_V 63_I 1.487 0.99
92_L 178_L 1.47 0.99
204_Q 208_N 1.464 0.99
129_L 133_C 1.462 0.99
313_K 317_K 1.46 0.99
108_A 207_F 1.449 0.99
250_T 271_Q 1.447 0.99
13_I 300_S 1.447 0.99
101_M 180_L 1.446 0.99
81_L 96_T 1.431 0.98
70_I 95_Y 1.42 0.98
279_I 309_H 1.406 0.98
236_V 263_L 1.402 0.98
20_I 64_I 1.399 0.98
104_L 132_V 1.389 0.98
140_E 147_V 1.388 0.98
218_L 221_P 1.387 0.98
71_E 82_H 1.382 0.98
212_H 216_T 1.347 0.97
206_V 209_A 1.341 0.97
265_A 268_L 1.334 0.97
142_A 145_K 1.329 0.97
36_A 43_V 1.327 0.97
11_F 230_F 1.327 0.97
139_V 174_V 1.324 0.97
25_D 28_Q 1.299 0.97
313_K 316_E 1.296 0.97
128_E 131_R 1.29 0.96
80_Y 179_R 1.282 0.96
263_L 320_V 1.28 0.96
19_H 61_T 1.28 0.96
272_C 318_F 1.28 0.96
278_Q 281_G 1.265 0.96
139_V 144_G 1.261 0.96
5_L 8_W 1.26 0.96
155_R 160_D 1.248 0.95
80_Y 177_G 1.248 0.95
26_E 30_L 1.234 0.95
277_M 313_K 1.221 0.95
149_L 171_F 1.217 0.95
227_A 230_F 1.205 0.94
307_A 324_P 1.202 0.94
70_I 87_E 1.196 0.94
114_V 176_V 1.195 0.94
117_S 122_I 1.192 0.94
209_A 213_M 1.19 0.94
211_C 215_T 1.187 0.94
285_H 288_Q 1.185 0.94
69_G 87_E 1.182 0.93
281_G 296_D 1.182 0.93
192_D 195_R 1.182 0.93
19_H 41_Q 1.18 0.93
134_A 177_G 1.176 0.93
138_S 163_F 1.169 0.93
311_R 321_W 1.167 0.93
13_I 53_L 1.158 0.93
292_L 303_V 1.156 0.92
6_K 297_N 1.152 0.92
53_L 326_V 1.152 0.92
272_C 317_K 1.15 0.92
54_F 330_G 1.137 0.92
83_V 92_L 1.135 0.92
230_F 307_A 1.128 0.91
205_Q 208_N 1.128 0.91
83_V 178_L 1.125 0.91
55_L 300_S 1.124 0.91
241_A 253_N 1.119 0.91
29_L 172_A 1.116 0.91
24_E 28_Q 1.114 0.91
282_A 306_L 1.112 0.90
304_V 328_F 1.106 0.90
298_A 303_V 1.103 0.90
314_V 318_F 1.098 0.90
130_Q 151_A 1.085 0.89
241_A 245_L 1.08 0.89
269_I 310_V 1.079 0.89
242_K 245_L 1.068 0.88
236_V 240_T 1.057 0.87
137_D 177_G 1.055 0.87
6_K 14_D 1.049 0.87
26_E 146_Q 1.048 0.87
22_C 64_I 1.048 0.87
118_P 176_V 1.047 0.87
55_L 328_F 1.045 0.86
256_Q 259_G 1.036 0.86
11_F 303_V 1.033 0.86
245_L 253_N 1.03 0.85
118_P 173_I 1.023 0.85
266_G 275_K 1.023 0.85
265_A 314_V 1.023 0.85
160_D 165_H 1.018 0.84
110_I 124_A 1.01 0.84
208_N 212_H 1.009 0.84
44_L 62_V 1.004 0.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3i99A10.99421000.198Contact Map0.819
4jb1A10.95911000.24Contact Map0.8
1uxyA10.99421000.274Contact Map0.796
1hskA10.8481000.313Contact Map0.88
2gqtA10.75731000.315Contact Map0.712
3tx1A10.82461000.378Contact Map0.852
1wvfA10.88399.90.759Contact Map0.57
3nvzB20.771999.90.76Contact Map0.497
2exrA10.868499.90.773Contact Map0.606
1zr6A10.783699.90.777Contact Map0.601
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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