| UniProt: | P08244 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG10809 | ||
| Length: | 245 (229) | ||
| Sequences: | 1382 | ||
| Seq/Len: | 6.03 |
| PYRF
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs Cluster includes: PYRF SGBH ULAD |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 229_D | 232_Q | 3.658 | 1.00 | |
| 100_A | 126_A | 3.557 | 1.00 | |
| 34_D | 64_R | 3.455 | 1.00 | |
| 25_N | 28_D | 3.202 | 1.00 | |
| 17_V | 220_I | 3.173 | 1.00 | |
| 62_Q | 94_W | 3.059 | 1.00 | |
| 227_S | 233_T | 2.473 | 1.00 | |
| 134_E | 202_R | 2.333 | 1.00 | |
| 170_A | 205_M | 2.231 | 1.00 | |
| 105_R | 202_R | 2.21 | 1.00 | |
| 102_G | 106_M | 2.188 | 1.00 | |
| 56_Q | 59_R | 2.184 | 1.00 | |
| 196_S | 223_P | 2.128 | 1.00 | |
| 232_Q | 236_A | 2.097 | 1.00 | |
| 104_A | 140_D | 1.977 | 1.00 | |
| 135_A | 147_P | 1.962 | 1.00 | |
| 82_A | 112_E | 1.956 | 1.00 | |
| 205_M | 213_A | 1.947 | 1.00 | |
| 208_E | 240_S | 1.92 | 1.00 | |
| 26_R | 60_E | 1.915 | 1.00 | |
| 104_A | 108_T | 1.903 | 1.00 | |
| 177_K | 216_D | 1.85 | 1.00 | |
| 193_P | 196_S | 1.838 | 1.00 | |
| 231_A | 235_K | 1.819 | 1.00 | |
| 208_E | 212_S | 1.811 | 1.00 | |
| 74_F | 88_A | 1.792 | 1.00 | |
| 177_K | 186_L | 1.77 | 1.00 | |
| 111_R | 115_V | 1.744 | 1.00 | |
| 107_M | 163_L | 1.719 | 1.00 | |
| 30_L | 60_E | 1.712 | 1.00 | |
| 23_Y | 32_F | 1.705 | 1.00 | |
| 47_K | 51_T | 1.695 | 1.00 | |
| 159_Q | 181_G | 1.683 | 1.00 | |
| 215_V | 218_M | 1.653 | 1.00 | |
| 195_G | 199_G | 1.638 | 1.00 | |
| 193_P | 223_P | 1.637 | 1.00 | |
| 135_A | 146_S | 1.615 | 1.00 | |
| 104_A | 160_K | 1.61 | 0.99 | |
| 32_F | 36_I | 1.607 | 0.99 | |
| 176_F | 186_L | 1.604 | 0.99 | |
| 125_I | 163_L | 1.593 | 0.99 | |
| 188_T | 215_V | 1.522 | 0.99 | |
| 18_V | 42_R | 1.504 | 0.99 | |
| 39_R | 235_K | 1.501 | 0.99 | |
| 152_E | 179_V | 1.49 | 0.99 | |
| 105_R | 137_D | 1.471 | 0.99 | |
| 211_L | 218_M | 1.466 | 0.99 | |
| 45_V | 61_L | 1.465 | 0.99 | |
| 35_K | 230_P | 1.453 | 0.99 | |
| 104_A | 161_C | 1.409 | 0.98 | |
| 138_L | 143_M | 1.406 | 0.98 | |
| 209_Q | 212_S | 1.403 | 0.98 | |
| 33_V | 43_L | 1.394 | 0.98 | |
| 193_P | 237_I | 1.394 | 0.98 | |
| 31_A | 35_K | 1.383 | 0.98 | |
| 43_L | 66_F | 1.381 | 0.98 | |
| 85_V | 96_V | 1.369 | 0.98 | |
| 133_M | 137_D | 1.365 | 0.98 | |
| 166_V | 184_F | 1.363 | 0.98 | |
| 170_A | 191_I | 1.362 | 0.98 | |
| 17_V | 234_L | 1.36 | 0.98 | |
| 52_L | 87_A | 1.342 | 0.98 | |
| 168_C | 186_L | 1.316 | 0.97 | |
| 105_R | 108_T | 1.306 | 0.97 | |
| 83_H | 86_A | 1.297 | 0.97 | |
| 98_V | 124_L | 1.291 | 0.97 | |
| 81_A | 106_M | 1.28 | 0.96 | |
| 145_L | 149_D | 1.26 | 0.96 | |
| 174_V | 178_Q | 1.257 | 0.96 | |
| 236_A | 239_A | 1.256 | 0.96 | |
| 199_G | 226_Q | 1.253 | 0.96 | |
| 236_A | 240_S | 1.249 | 0.96 | |
| 49_M | 57_F | 1.237 | 0.95 | |
| 195_G | 236_A | 1.229 | 0.95 | |
| 97_N | 127_V | 1.222 | 0.95 | |
| 101_S | 154_L | 1.213 | 0.95 | |
| 49_M | 53_F | 1.211 | 0.95 | |
| 235_K | 239_A | 1.21 | 0.95 | |
| 41_C | 234_L | 1.208 | 0.95 | |
| 81_A | 110_A | 1.2 | 0.94 | |
| 209_Q | 213_A | 1.197 | 0.94 | |
| 232_Q | 235_K | 1.187 | 0.94 | |
| 129_V | 133_M | 1.187 | 0.94 | |
| 19_V | 225_T | 1.182 | 0.94 | |
| 35_K | 229_D | 1.179 | 0.94 | |
| 82_A | 113_A | 1.179 | 0.94 | |
| 150_Y | 154_L | 1.171 | 0.93 | |
| 156_A | 179_V | 1.164 | 0.93 | |
| 134_E | 137_D | 1.157 | 0.93 | |
| 41_C | 66_F | 1.157 | 0.93 | |
| 97_N | 107_M | 1.153 | 0.93 | |
| 159_Q | 180_F | 1.153 | 0.93 | |
| 17_V | 241_L | 1.131 | 0.92 | |
| 17_V | 238_N | 1.131 | 0.92 | |
| 97_N | 125_I | 1.126 | 0.92 | |
| 28_D | 31_A | 1.122 | 0.91 | |
| 108_T | 112_E | 1.116 | 0.91 | |
| 146_S | 149_D | 1.106 | 0.91 | |
| 110_A | 113_A | 1.101 | 0.90 | |
| 198_A | 202_R | 1.098 | 0.90 | |
| 51_T | 74_F | 1.091 | 0.90 | |
| 198_A | 204_I | 1.081 | 0.89 | |
| 26_R | 53_F | 1.072 | 0.89 | |
| 168_C | 176_F | 1.072 | 0.89 | |
| 123_L | 185_K | 1.061 | 0.88 | |
| 70_L | 93_V | 1.059 | 0.88 | |
| 136_S | 139_V | 1.049 | 0.87 | |
| 176_F | 180_F | 1.047 | 0.87 | |
| 126_A | 163_L | 1.027 | 0.86 | |
| 95_M | 123_L | 1.025 | 0.85 | |
| 20_A | 221_G | 1.017 | 0.85 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 1eixA | 4 | 1 | 100 | 0.32 | Contact Map | 0.808 |
| 3gdmA | 2 | 0.9469 | 100 | 0.348 | Contact Map | 0.545 |
| 3tr2A | 2 | 0.9714 | 100 | 0.35 | Contact Map | 0.78 |
| 3ldvA | 2 | 0.9878 | 100 | 0.353 | Contact Map | 0.76 |
| 2yyuA | 2 | 0.9592 | 100 | 0.369 | Contact Map | 0.843 |
| 1dbtA | 3 | 0.9551 | 100 | 0.375 | Contact Map | 0.85 |
| 3qw4B | 2 | 0.9184 | 100 | 0.376 | Contact Map | 0.473 |
| 3tfxA | 2 | 0.9592 | 100 | 0.379 | Contact Map | 0.769 |
| 3r89A | 2 | 0.9469 | 100 | 0.389 | Contact Map | 0.42 |
| 3l52A | 1 | 0.9347 | 100 | 0.393 | Contact Map | 0.395 |
Sequence Conservation (Image Generated using WebLogo v3)