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OPENSEQ.org
TYPH - Thymidine phosphorylase
UniProt: P07650 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10219
Length: 440 (436)
Sequences: 942
Seq/Len: 2.16
TYPH
Paralog alert: 0.05 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
42_L 46_I 4.825 1.00
16_A 52_T 4.148 1.00
218_E 436_R 4.058 1.00
386_M 401_V 3.585 1.00
14_G 49_H 3.518 1.00
10_K 21_E 3.453 1.00
19_D 58_S 3.278 1.00
312_V 315_R 3.159 1.00
134_D 141_R 3.158 1.00
54_P 58_S 3.091 1.00
16_A 54_P 3.09 1.00
144_E 148_D 3.078 1.00
25_F 39_I 3.021 1.00
352_S 424_A 2.948 1.00
348_E 394_D 2.711 1.00
250_A 359_L 2.607 1.00
213_T 216_L 2.519 1.00
205_V 239_L 2.518 1.00
303_V 306_N 2.518 1.00
387_A 397_R 2.517 1.00
104_A 303_V 2.446 1.00
302_A 306_N 2.445 1.00
95_S 153_I 2.424 1.00
138_D 141_R 2.409 1.00
359_L 417_V 2.405 1.00
280_C 300_L 2.299 1.00
19_D 54_P 2.288 1.00
346_D 418_K 2.264 1.00
101_M 300_L 2.216 1.00
145_I 149_V 2.187 1.00
348_E 395_G 2.145 1.00
102_V 283_M 2.108 0.99
222_E 226_G 2.102 0.99
7_I 25_F 2.031 0.99
105_C 303_V 2.03 0.99
25_F 42_L 2.03 0.99
343_V 417_V 1.966 0.99
302_A 308_K 1.951 0.99
314_G 328_E 1.927 0.99
68_T 159_S 1.896 0.99
249_S 384_T 1.888 0.99
82_V 198_A 1.866 0.98
351_V 354_M 1.842 0.98
282_E 437_R 1.835 0.98
281_V 296_A 1.825 0.98
97_M 272_L 1.823 0.98
216_L 219_A 1.811 0.98
10_K 15_H 1.795 0.98
292_D 295_E 1.77 0.98
212_P 357_R 1.759 0.97
51_M 181_P 1.757 0.97
363_V 368_G 1.725 0.97
27_N 31_D 1.7 0.97
342_A 401_V 1.698 0.97
254_V 384_T 1.696 0.97
64_R 192_L 1.694 0.97
141_R 144_E 1.691 0.97
344_Y 398_P 1.679 0.96
19_D 23_R 1.676 0.96
261_Q 266_E 1.67 0.96
277_M 300_L 1.659 0.96
372_Q 375_D 1.656 0.96
7_I 42_L 1.655 0.96
124_L 135_I 1.631 0.96
149_V 319_A 1.62 0.95
57_V 230_G 1.618 0.95
96_L 256_V 1.597 0.95
353_E 422_K 1.589 0.95
301_Q 305_D 1.586 0.95
371_R 375_D 1.583 0.94
303_V 308_K 1.575 0.94
184_T 227_V 1.532 0.93
340_T 401_V 1.528 0.93
338_M 405_K 1.519 0.93
3_L 6_E 1.51 0.92
175_A 178_D 1.504 0.92
137_P 145_I 1.503 0.92
228_A 235_T 1.492 0.92
65_D 69_V 1.453 0.90
107_G 289_L 1.45 0.90
53_M 226_G 1.448 0.90
64_R 69_V 1.448 0.90
78_N 147_K 1.425 0.89
383_F 400_A 1.422 0.89
354_M 421_I 1.422 0.89
101_M 280_C 1.415 0.89
347_T 425_D 1.415 0.89
264_T 310_A 1.415 0.89
355_D 358_A 1.406 0.88
95_S 111_M 1.405 0.88
394_D 397_R 1.385 0.87
105_C 284_L 1.385 0.87
29_I 39_I 1.384 0.87
290_A 296_A 1.382 0.87
110_P 199_L 1.376 0.87
188_L 228_A 1.375 0.87
343_V 400_A 1.373 0.87
7_I 39_I 1.372 0.87
56_R 223_A 1.371 0.87
192_L 231_A 1.367 0.87
384_T 403_H 1.363 0.86
359_L 383_F 1.359 0.86
111_M 199_L 1.349 0.86
270_P 274_D 1.346 0.85
25_F 46_I 1.345 0.85
205_V 217_S 1.335 0.85
262_F 273_F 1.335 0.85
350_F 392_Q 1.329 0.84
28_G 33_T 1.314 0.83
146_I 194_E 1.308 0.83
201_M 224_I 1.307 0.83
61_M 231_A 1.306 0.83
98_L 280_C 1.303 0.83
184_T 223_A 1.303 0.83
13_D 47_F 1.29 0.82
381_V 402_I 1.29 0.82
79_G 108_Y 1.285 0.82
254_V 403_H 1.284 0.81
9_R 175_A 1.279 0.81
262_F 269_N 1.277 0.81
323_P 333_Y 1.276 0.81
77_L 81_I 1.272 0.81
273_F 305_D 1.269 0.80
43_A 167_F 1.269 0.80
336_T 403_H 1.262 0.80
378_D 405_K 1.251 0.79
97_M 262_F 1.25 0.79
256_V 259_A 1.246 0.79
9_R 178_D 1.227 0.77
325_D 333_Y 1.213 0.76
342_A 398_P 1.21 0.76
23_R 58_S 1.203 0.75
249_S 254_V 1.201 0.75
133_F 320_Q 1.2 0.75
381_V 404_A 1.187 0.74
411_Q 414_A 1.182 0.73
336_T 380_S 1.181 0.73
93_V 258_E 1.18 0.73
142_F 152_A 1.18 0.73
99_G 151_V 1.166 0.72
341_K 414_A 1.163 0.72
7_I 24_F 1.159 0.71
406_D 409_N 1.153 0.71
253_A 257_R 1.15 0.70
410_W 413_A 1.149 0.70
238_L 437_R 1.147 0.70
9_R 13_D 1.146 0.70
50_D 181_P 1.138 0.69
146_I 160_L 1.137 0.69
205_V 435_Y 1.127 0.68
68_T 397_R 1.123 0.68
76_H 143_R 1.122 0.68
101_M 303_V 1.121 0.68
93_V 247_A 1.121 0.68
340_T 403_H 1.12 0.68
380_S 405_K 1.117 0.67
72_W 81_I 1.116 0.67
318_A 324_T 1.113 0.67
57_V 231_A 1.108 0.66
53_M 230_G 1.107 0.66
130_I 317_V 1.1 0.65
17_L 42_L 1.096 0.65
18_S 32_N 1.094 0.65
241_D 431_T 1.09 0.64
296_A 300_L 1.089 0.64
274_D 297_R 1.087 0.64
94_T 272_L 1.085 0.64
196_L 199_L 1.084 0.64
188_L 227_V 1.082 0.64
96_L 100_P 1.072 0.63
61_M 65_D 1.072 0.63
17_L 22_I 1.071 0.62
414_A 418_K 1.071 0.62
207_S 355_D 1.063 0.62
225_V 438_I 1.059 0.61
4_A 25_F 1.055 0.61
124_L 316_M 1.052 0.60
11_K 55_E 1.052 0.60
124_L 199_L 1.048 0.60
12_R 178_D 1.041 0.59
285_I 292_D 1.037 0.59
104_A 107_G 1.037 0.59
36_E 373_A 1.037 0.59
184_T 188_L 1.035 0.59
427_A 437_R 1.035 0.59
112_I 196_L 1.033 0.58
351_V 420_A 1.028 0.58
199_L 233_V 1.026 0.58
253_A 380_S 1.024 0.57
72_W 77_L 1.02 0.57
22_I 51_M 1.017 0.57
73_K 81_I 1.015 0.56
362_A 417_V 1.011 0.56
101_M 104_A 1.01 0.56
111_M 196_L 1.008 0.56
36_E 40_A 1.007 0.55
98_L 279_L 1.002 0.55
289_L 299_K 1.002 0.55
415_K 419_A 1.001 0.55
68_T 139_D 1.001 0.55
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1brwA20.98411000.288Contact Map0.774
3h5qA10.98641000.29Contact Map0.769
4eadA10.99321000.296Contact Map0.727
2dsjA20.96141000.304Contact Map0.773
1uouA10.99091000.311Contact Map0.695
4ga6A20.94771000.396Contact Map0.703
1vquA20.70231000.627Contact Map0.524
2elcA40.6751000.634Contact Map0.531
3r88A20.71000.637Contact Map0.527
4giuA20.71000.639Contact Map0.549
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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