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OPENSEQ.org
SYFB - Phenylalanine--tRNA ligase beta subunit
UniProt: P07395 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10710
Length: 795 (795)
Sequences: 1721
Seq/Len: 2.16
SYFB
Paralog alert: 0.00 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
270_D 330_N 6.619 1.00
715_A 753_Y 4.725 1.00
594_G 682_F 4.665 1.00
49_E 89_R 4.092 1.00
286_T 294_E 4.04 1.00
52_E 66_K 4.035 1.00
716_E 745_R 3.876 1.00
48_G 92_V 3.863 1.00
259_E 375_R 3.516 1.00
267_F 312_A 3.428 1.00
286_T 296_K 3.408 1.00
221_V 333_L 3.348 1.00
88_L 136_E 3.209 1.00
49_E 68_N 3.18 1.00
218_G 332_L 3.119 1.00
220_V 269_K 3.072 1.00
51_V 74_L 3.067 1.00
556_V 595_V 3.014 1.00
77_I 92_V 2.936 1.00
435_C 455_M 2.851 1.00
711_A 757_A 2.841 1.00
216_Y 267_F 2.836 1.00
85_R 88_L 2.739 1.00
409_R 458_E 2.734 1.00
301_T 349_R 2.725 1.00
50_V 84_C 2.724 1.00
283_E 299_A 2.691 1.00
736_V 763_Q 2.686 1.00
429_I 468_V 2.666 1.00
58_N 113_E 2.619 1.00
85_R 136_E 2.596 1.00
289_L 295_A 2.554 1.00
292_G 320_E 2.526 1.00
648_Q 664_V 2.512 1.00
216_Y 312_A 2.505 1.00
230_T 234_M 2.5 1.00
716_E 752_G 2.492 1.00
281_A 297_L 2.491 1.00
128_S 131_H 2.456 1.00
253_T 266_A 2.448 1.00
510_V 569_I 2.437 1.00
55_Q 63_R 2.416 1.00
412_K 458_E 2.412 1.00
223_G 387_E 2.398 1.00
221_V 386_G 2.393 1.00
726_E 789_F 2.369 1.00
413_L 426_V 2.347 1.00
311_L 322_S 2.344 1.00
141_A 150_Y 2.322 1.00
740_L 756_L 2.316 1.00
17_D 20_A 2.293 1.00
735_V 760_L 2.29 1.00
762_L 778_V 2.281 1.00
721_A 725_S 2.269 1.00
51_V 68_N 2.266 1.00
217_L 373_M 2.21 1.00
512_T 555_T 2.188 1.00
410_R 426_V 2.186 1.00
637_R 651_A 2.168 1.00
446_A 461_L 2.152 1.00
271_R 325_N 2.148 1.00
149_E 154_D 2.13 1.00
10_E 237_K 2.12 0.99
33_D 161_S 2.095 0.99
719_P 722_D 2.068 0.99
518_P 542_S 2.061 0.99
378_R 382_D 2.052 0.99
637_R 653_Y 2.042 0.99
741_F 757_A 2.024 0.99
225_N 228_A 2.02 0.99
69_V 75_L 2.009 0.99
510_V 555_T 2.008 0.99
273_E 308_N 2.007 0.99
69_V 92_V 1.995 0.99
507_Y 620_D 1.989 0.99
13_N 188_V 1.978 0.99
241_C 258_L 1.969 0.99
221_V 380_L 1.964 0.99
549_W 681_V 1.962 0.99
767_R 773_E 1.954 0.99
89_R 143_I 1.919 0.99
219_R 374_E 1.907 0.99
653_Y 658_R 1.889 0.99
222_K 330_N 1.885 0.99
274_G 307_H 1.879 0.99
428_D 432_R 1.864 0.98
48_G 69_V 1.86 0.98
45_V 91_A 1.839 0.98
298_N 349_R 1.832 0.98
279_R 285_E 1.827 0.98
406_I 455_M 1.815 0.98
651_A 658_R 1.792 0.98
279_R 305_A 1.782 0.98
555_T 569_I 1.77 0.98
22_A 35_V 1.767 0.98
122_F 135_I 1.759 0.97
53_C 84_C 1.742 0.97
229_P 235_K 1.74 0.97
367_A 450_S 1.731 0.97
123_S 131_H 1.73 0.97
764_D 767_R 1.729 0.97
301_T 346_R 1.724 0.97
44_G 94_T 1.715 0.97
216_Y 276_I 1.714 0.97
95_I 108_A 1.712 0.97
645_H 667_P 1.71 0.97
19_D 23_N 1.709 0.97
414_D 420_H 1.704 0.97
252_V 383_I 1.69 0.97
646_P 666_H 1.688 0.97
145_T 149_E 1.683 0.96
89_R 141_A 1.68 0.96
52_E 86_Q 1.671 0.96
409_R 412_K 1.666 0.96
84_C 88_L 1.662 0.96
160_I 175_V 1.661 0.96
645_H 666_H 1.661 0.96
316_I 346_R 1.655 0.96
635_E 656_G 1.652 0.96
380_L 386_G 1.65 0.96
47_V 141_A 1.649 0.96
232_L 236_E 1.648 0.96
235_K 245_S 1.644 0.96
660_G 684_L 1.639 0.96
252_V 376_A 1.635 0.96
53_C 63_R 1.634 0.96
69_V 94_T 1.631 0.96
76_D 114_P 1.621 0.95
711_A 741_F 1.615 0.95
301_T 350_H 1.614 0.95
714_V 723_I 1.612 0.95
89_R 140_D 1.609 0.95
288_V 294_E 1.604 0.95
553_L 595_V 1.599 0.95
287_L 313_M 1.594 0.95
208_E 277_V 1.592 0.95
779_A 783_E 1.592 0.95
55_Q 59_A 1.588 0.95
408_L 461_L 1.582 0.94
28_A 182_L 1.581 0.94
273_E 309_K 1.581 0.94
489_R 492_D 1.58 0.94
416_L 459_E 1.575 0.94
48_G 77_I 1.573 0.94
212_A 280_M 1.568 0.94
4_S 155_D 1.562 0.94
723_I 756_L 1.559 0.94
264_M 376_A 1.559 0.94
56_H 59_A 1.553 0.94
12_V 179_V 1.553 0.94
171_G 261_G 1.553 0.94
5_E 18_S 1.546 0.94
203_L 272_I 1.543 0.93
222_K 387_E 1.542 0.93
98_V 103_F 1.539 0.93
417_I 466_A 1.538 0.93
276_I 312_A 1.538 0.93
91_A 147_I 1.533 0.93
272_I 311_L 1.532 0.93
786_K 792_S 1.532 0.93
91_A 135_I 1.531 0.93
50_V 53_C 1.53 0.93
510_V 552_L 1.528 0.93
209_A 280_M 1.527 0.93
55_Q 61_K 1.524 0.93
21_L 179_V 1.51 0.92
203_L 332_L 1.507 0.92
98_V 104_K 1.506 0.92
264_M 333_L 1.5 0.92
281_A 285_E 1.499 0.92
353_H 358_H 1.499 0.92
713_V 750_A 1.499 0.92
724_L 728_K 1.493 0.92
617_L 662_V 1.488 0.92
644_L 681_V 1.484 0.92
239_R 245_S 1.484 0.92
408_L 413_L 1.476 0.91
727_C 781_C 1.474 0.91
270_D 329_Q 1.47 0.91
353_H 362_R 1.465 0.91
47_V 89_R 1.465 0.91
744_Y 750_A 1.464 0.91
358_H 362_R 1.46 0.91
407_T 445_Q 1.457 0.91
119_L 136_E 1.451 0.90
422_A 425_Q 1.448 0.90
269_K 332_L 1.447 0.90
547_S 550_T 1.446 0.90
720_A 756_L 1.442 0.90
664_V 680_L 1.438 0.90
729_K 788_R 1.435 0.90
98_V 102_D 1.433 0.90
217_L 369_Q 1.431 0.90
316_I 343_I 1.422 0.89
208_E 282_K 1.421 0.89
30_L 169_C 1.419 0.89
306_D 309_K 1.415 0.89
59_A 111_R 1.412 0.89
69_V 77_I 1.408 0.89
746_G 749_V 1.403 0.88
589_D 685_E 1.403 0.88
312_A 356_A 1.395 0.88
215_R 393_D 1.395 0.88
46_V 94_T 1.393 0.88
217_L 370_H 1.389 0.88
783_E 786_K 1.379 0.87
180_A 187_L 1.378 0.87
762_L 777_T 1.374 0.87
448_A 455_M 1.373 0.87
138_P 141_A 1.37 0.87
365_D 450_S 1.361 0.86
75_L 95_I 1.36 0.86
91_A 134_I 1.359 0.86
621_L 625_L 1.354 0.86
107_A 114_P 1.352 0.86
177_R 451_W 1.351 0.86
230_T 235_K 1.347 0.85
664_V 678_R 1.347 0.85
142_P 150_Y 1.345 0.85
249_V 380_L 1.341 0.85
413_L 465_V 1.339 0.85
283_E 298_N 1.339 0.85
205_I 218_G 1.337 0.85
223_G 329_Q 1.337 0.85
518_P 532_L 1.325 0.84
356_A 360_Y 1.315 0.83
596_I 617_L 1.31 0.83
312_A 338_F 1.309 0.83
256_V 375_R 1.306 0.83
76_D 116_E 1.304 0.83
93_A 97_A 1.304 0.83
162_V 170_L 1.298 0.82
305_A 310_A 1.296 0.82
216_Y 338_F 1.296 0.82
414_D 419_H 1.293 0.82
347_A 357_S 1.292 0.82
20_A 23_N 1.29 0.82
750_A 753_Y 1.287 0.82
54_A 113_E 1.286 0.82
216_Y 335_C 1.284 0.81
64_V 76_D 1.281 0.81
60_D 111_R 1.28 0.81
503_N 570_F 1.277 0.81
234_M 255_Y 1.273 0.81
274_G 306_D 1.273 0.81
56_H 111_R 1.269 0.80
47_V 145_T 1.269 0.80
64_V 113_E 1.261 0.80
600_R 610_E 1.26 0.80
73_R 116_E 1.25 0.79
732_V 735_V 1.249 0.79
712_V 785_L 1.244 0.79
56_H 60_D 1.24 0.78
63_R 79_C 1.24 0.78
746_G 750_A 1.237 0.78
377_T 388_A 1.233 0.78
243_I 355_D 1.232 0.78
377_T 381_I 1.229 0.77
248_A 384_C 1.224 0.77
375_R 379_L 1.224 0.77
224_I 249_V 1.22 0.77
88_L 119_L 1.215 0.76
234_M 383_I 1.212 0.76
405_T 447_V 1.212 0.76
302_L 314_G 1.209 0.76
505_K 623_S 1.207 0.76
190_P 375_R 1.206 0.75
427_T 431_R 1.205 0.75
317_F 354_T 1.203 0.75
753_Y 792_S 1.197 0.75
557_V 561_N 1.196 0.75
66_K 74_L 1.195 0.75
410_R 423_D 1.194 0.74
253_T 333_L 1.194 0.74
644_L 649_S 1.19 0.74
285_E 303_V 1.187 0.74
279_R 287_L 1.187 0.74
279_R 303_V 1.184 0.74
459_E 462_V 1.184 0.74
412_K 415_R 1.182 0.73
412_K 462_V 1.175 0.73
49_E 143_I 1.167 0.72
621_L 682_F 1.165 0.72
140_D 150_Y 1.164 0.72
785_L 791_A 1.164 0.72
252_V 380_L 1.16 0.71
59_A 63_R 1.159 0.71
646_P 667_P 1.159 0.71
84_C 136_E 1.157 0.71
142_P 145_T 1.153 0.71
657_E 688_K 1.151 0.71
298_N 301_T 1.149 0.70
425_Q 428_D 1.146 0.70
775_A 779_A 1.144 0.70
711_A 794_R 1.141 0.70
764_D 773_E 1.137 0.69
502_L 592_L 1.134 0.69
18_S 156_N 1.129 0.68
170_L 358_H 1.119 0.67
762_L 774_I 1.119 0.67
498_V 686_W 1.119 0.67
436_E 447_V 1.115 0.67
594_G 617_L 1.112 0.67
219_R 377_T 1.111 0.67
431_R 437_V 1.11 0.67
147_I 151_L 1.109 0.66
309_K 321_H 1.108 0.66
408_L 462_V 1.108 0.66
66_K 76_D 1.107 0.66
346_R 354_T 1.107 0.66
569_I 595_V 1.107 0.66
755_S 794_R 1.106 0.66
122_F 128_S 1.103 0.66
256_V 259_E 1.101 0.66
283_E 296_K 1.101 0.66
221_V 331_V 1.1 0.65
520_V 554_A 1.098 0.65
119_L 134_I 1.098 0.65
52_E 74_L 1.093 0.65
24_Q 183_N 1.091 0.65
337_F 340_P 1.091 0.65
253_T 264_M 1.09 0.64
82_P 88_L 1.09 0.64
324_V 331_V 1.088 0.64
287_L 305_A 1.085 0.64
45_V 125_L 1.084 0.64
92_V 119_L 1.083 0.64
276_I 338_F 1.082 0.64
5_E 9_R 1.08 0.63
333_L 377_T 1.08 0.63
295_A 323_G 1.078 0.63
720_A 758_I 1.075 0.63
143_I 150_Y 1.075 0.63
51_V 86_Q 1.075 0.63
342_S 346_R 1.074 0.63
167_A 453_F 1.072 0.63
45_V 99_L 1.069 0.62
50_V 136_E 1.069 0.62
617_L 682_F 1.069 0.62
784_A 788_R 1.067 0.62
685_E 688_K 1.067 0.62
396_N 399_T 1.066 0.62
333_L 380_L 1.062 0.61
430_L 461_L 1.061 0.61
266_A 333_L 1.059 0.61
707_R 759_S 1.059 0.61
295_A 352_L 1.058 0.61
714_V 754_K 1.057 0.61
291_D 295_A 1.057 0.61
76_D 113_E 1.054 0.61
104_K 107_A 1.05 0.60
722_D 789_F 1.048 0.60
47_V 150_Y 1.047 0.60
75_L 116_E 1.047 0.60
416_L 462_V 1.046 0.60
4_S 172_I 1.04 0.59
505_K 620_D 1.04 0.59
425_Q 473_N 1.039 0.59
31_E 161_S 1.037 0.59
746_G 752_G 1.035 0.59
256_V 379_L 1.031 0.58
381_I 388_A 1.029 0.58
749_V 752_G 1.029 0.58
227_K 248_A 1.027 0.58
287_L 303_V 1.027 0.58
107_A 116_E 1.026 0.58
3_F 172_I 1.026 0.58
24_Q 182_L 1.026 0.58
66_K 75_L 1.025 0.57
16_I 21_L 1.022 0.57
551_G 573_G 1.022 0.57
715_A 754_K 1.021 0.57
714_V 791_A 1.017 0.57
532_L 543_A 1.015 0.56
79_C 119_L 1.011 0.56
722_D 788_R 1.009 0.56
229_P 248_A 1.008 0.56
169_C 178_D 1.008 0.56
81_A 133_G 1.006 0.55
206_T 277_V 1.006 0.55
410_R 444_W 1.005 0.55
230_T 248_A 1.003 0.55
53_C 88_L 1.003 0.55
235_K 239_R 1.003 0.55
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3pcoB20.99751000.068Contact Map0.788
2rhqB10.98241000.077Contact Map0.758
1b7yB10.96981000.079Contact Map0.7
3l4gB80.67041000.534Contact Map0.623
2cxiA30.39251000.724Contact Map0.624
3cmqA10.42141000.758Contact Map0.381
2odrA10.44281000.785Contact Map0.66
2du7A40.42891000.785Contact Map0.416
2odrB10.44281000.785Contact Map0.659
2odrD10.44281000.785Contact Map0.697
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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