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OPENSEQ.org
SYV - Valine--tRNA ligase
UniProt: P07118 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11067
Length: 951 (892)
Sequences: 3456
Seq/Len: 3.87
SYV
Paralog alert: 0.53 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: SYI SYL SYV
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
332_F 347_A 5.994 1.00
66_Q 71_K 5.089 1.00
163_E 525_H 4.592 1.00
109_A 112_D 4.387 1.00
553_Q 559_K 4.217 1.00
16_E 20_K 4.18 1.00
302_T 306_D 3.989 1.00
500_H 523_T 3.946 1.00
335_L 343_A 3.72 1.00
113_K 116_E 3.72 1.00
679_A 794_L 3.554 1.00
675_R 790_D 3.544 1.00
176_D 370_G 3.45 1.00
249_Y 258_R 3.341 1.00
331_E 347_A 3.12 1.00
6_N 9_D 3.066 1.00
689_R 781_F 3.064 1.00
22_G 25_K 3.059 1.00
19_E 130_R 2.982 1.00
179_L 370_G 2.906 1.00
903_I 931_L 2.905 1.00
217_L 275_C 2.903 1.00
403_Q 540_T 2.879 1.00
246_I 263_G 2.879 1.00
194_K 361_D 2.844 1.00
907_E 935_A 2.834 1.00
155_E 449_R 2.82 1.00
744_E 748_R 2.818 1.00
683_Q 794_L 2.809 1.00
232_G 262_V 2.785 1.00
69_Q 689_R 2.782 1.00
233_V 250_V 2.769 1.00
896_V 938_K 2.764 1.00
680_E 711_Q 2.738 1.00
608_P 632_M 2.686 1.00
913_E 917_A 2.673 1.00
407_K 410_E 2.567 1.00
251_I 256_N 2.565 1.00
434_R 468_Q 2.563 1.00
391_K 395_E 2.543 1.00
925_A 929_E 2.54 1.00
681_F 745_G 2.518 1.00
921_E 925_A 2.511 1.00
900_E 942_I 2.493 1.00
176_D 179_L 2.488 1.00
149_L 485_S 2.471 1.00
904_S 908_N 2.451 1.00
155_E 159_R 2.442 1.00
686_K 690_E 2.423 1.00
402_I 520_I 2.402 1.00
550_D 631_D 2.399 1.00
307_I 329_P 2.384 1.00
159_R 162_K 2.381 1.00
492_N 497_R 2.38 1.00
192_E 361_D 2.369 1.00
159_R 163_E 2.366 1.00
346_A 349_D 2.352 1.00
15_Y 756_F 2.348 1.00
387_D 391_K 2.308 1.00
346_A 350_A 2.292 1.00
106_G 109_A 2.278 1.00
176_D 367_G 2.237 1.00
234_A 278_I 2.236 1.00
540_T 695_F 2.235 1.00
25_K 139_E 2.218 1.00
838_N 841_R 2.21 1.00
201_R 216_Y 2.206 1.00
512_I 543_M 2.199 1.00
290_G 295_L 2.181 1.00
205_A 258_R 2.176 1.00
101_T 104_D 2.171 1.00
677_I 742_V 2.164 1.00
233_V 275_C 2.163 1.00
194_K 359_P 2.145 1.00
192_E 363_T 2.139 1.00
347_A 350_A 2.137 1.00
841_R 845_Q 2.133 1.00
37_I 63_I 2.122 1.00
394_V 414_F 2.084 1.00
723_V 735_T 2.066 1.00
98_E 113_K 2.051 1.00
179_L 367_G 2.051 1.00
700_A 753_I 2.035 1.00
690_E 694_S 2.031 1.00
142_R 148_G 2.023 1.00
309_E 333_Q 2.007 1.00
347_A 351_L 2.007 1.00
131_R 570_D 1.994 1.00
550_D 633_K 1.991 1.00
367_G 370_G 1.99 1.00
649_S 761_I 1.966 1.00
162_K 449_R 1.966 1.00
404_F 512_I 1.963 1.00
398_E 418_R 1.949 1.00
66_Q 69_Q 1.943 1.00
56_Q 129_M 1.937 1.00
205_A 249_Y 1.929 1.00
250_V 261_I 1.913 1.00
65_Y 693_D 1.909 1.00
66_Q 693_D 1.903 1.00
215_D 244_D 1.897 1.00
300_I 307_I 1.881 1.00
89_V 92_R 1.879 1.00
151_N 491_E 1.868 1.00
196_S 359_P 1.866 1.00
14_L 760_T 1.855 1.00
398_E 410_E 1.855 1.00
392_P 395_E 1.843 1.00
467_R 470_E 1.842 1.00
343_A 346_A 1.84 1.00
170_K 380_D 1.837 1.00
63_I 73_T 1.832 1.00
307_I 340_A 1.832 1.00
750_A 758_T 1.829 1.00
687_A 703_I 1.818 1.00
892_L 941_L 1.816 1.00
56_Q 134_N 1.816 1.00
68_M 748_R 1.815 1.00
685_I 749_L 1.815 1.00
896_V 941_L 1.812 0.99
178_K 370_G 1.804 0.99
900_E 904_S 1.796 0.99
65_Y 69_Q 1.789 0.99
441_E 467_R 1.788 0.99
370_G 440_D 1.778 0.99
65_Y 689_R 1.775 0.99
385_R 388_V 1.767 0.99
931_L 935_A 1.763 0.99
889_L 945_Q 1.762 0.99
681_F 685_I 1.751 0.99
395_E 399_N 1.745 0.99
17_H 21_Q 1.742 0.99
33_E 71_K 1.742 0.99
17_H 763_Q 1.736 0.99
692_L 753_I 1.729 0.99
176_D 440_D 1.728 0.99
207_G 215_D 1.727 0.99
790_D 793_A 1.709 0.99
907_E 931_L 1.707 0.99
927_E 930_K 1.7 0.99
503_S 539_H 1.7 0.99
61_T 619_A 1.69 0.99
899_I 941_L 1.682 0.99
168_R 380_D 1.678 0.99
402_I 536_V 1.667 0.99
914_G 918_R 1.662 0.99
254_L 347_A 1.657 0.99
179_L 372_V 1.649 0.99
689_R 693_D 1.641 0.99
642_C 754_I 1.633 0.99
708_T 746_L 1.632 0.99
897_A 901_G 1.621 0.99
507_S 516_I 1.613 0.99
81_H 145_M 1.611 0.99
392_P 528_K 1.607 0.99
796_D 839_E 1.603 0.98
200_I 348_V 1.6 0.98
775_T 778_L 1.599 0.98
13_P 760_T 1.585 0.98
384_V 425_I 1.576 0.98
388_V 391_K 1.575 0.98
696_R 699_I 1.568 0.98
178_K 372_V 1.56 0.98
266_H 289_V 1.553 0.98
336_E 339_A 1.553 0.98
228_L 307_I 1.55 0.98
72_N 498_Q 1.54 0.98
180_R 304_D 1.537 0.98
349_D 357_I 1.533 0.98
682_N 685_I 1.53 0.98
648_A 713_C 1.53 0.98
87_Q 91_E 1.524 0.98
204_L 215_D 1.518 0.98
367_G 372_V 1.515 0.98
100_K 104_D 1.514 0.98
205_A 251_I 1.504 0.97
330_A 333_Q 1.501 0.97
238_E 265_E 1.5 0.97
440_D 444_N 1.497 0.97
685_I 745_G 1.493 0.97
267_A 271_K 1.492 0.97
158_V 162_K 1.491 0.97
68_M 751_H 1.488 0.97
129_M 134_N 1.48 0.97
893_A 897_A 1.476 0.97
906_I 931_L 1.468 0.97
398_E 414_F 1.459 0.97
201_R 355_E 1.455 0.97
16_E 19_E 1.455 0.97
480_A 522_M 1.451 0.97
893_A 945_Q 1.45 0.97
199_H 356_E 1.449 0.97
395_E 398_E 1.447 0.97
902_E 905_R 1.447 0.97
331_E 343_A 1.446 0.97
929_E 933_G 1.445 0.97
251_I 258_R 1.441 0.96
156_V 526_F 1.436 0.96
939_A 943_E 1.434 0.96
236_N 269_M 1.433 0.96
234_A 262_V 1.43 0.96
674_D 716_Y 1.417 0.96
219_V 233_V 1.41 0.96
93_K 113_K 1.4 0.96
176_D 372_V 1.394 0.95
234_A 264_D 1.392 0.95
35_F 62_M 1.389 0.95
901_G 905_R 1.389 0.95
903_I 938_K 1.381 0.95
884_N 887_D 1.38 0.95
823_E 852_S 1.378 0.95
897_A 900_E 1.376 0.95
680_E 798_E 1.374 0.95
103_H 106_G 1.371 0.95
288_E 291_K 1.367 0.95
72_N 499_F 1.364 0.95
193_S 366_Y 1.352 0.94
684_T 703_I 1.35 0.94
35_F 504_V 1.348 0.94
681_F 742_V 1.346 0.94
93_K 120_E 1.343 0.94
417_M 520_I 1.342 0.94
23_Y 778_L 1.339 0.94
199_H 218_V 1.336 0.94
133_G 756_F 1.336 0.94
204_L 261_I 1.331 0.94
834_E 838_N 1.326 0.94
909_K 927_E 1.325 0.94
231_T 298_I 1.321 0.93
529_D 536_V 1.32 0.93
798_E 801_K 1.319 0.93
403_Q 407_K 1.315 0.93
39_I 56_Q 1.314 0.93
179_L 440_D 1.314 0.93
411_N 415_S 1.313 0.93
807_V 848_A 1.311 0.93
232_G 278_I 1.309 0.93
483_T 500_H 1.305 0.93
616_F 701_A 1.304 0.93
410_E 414_F 1.302 0.93
302_T 308_R 1.297 0.93
394_V 418_R 1.297 0.93
126_T 141_E 1.296 0.93
720_T 735_T 1.291 0.92
686_K 784_Y 1.29 0.92
182_A 424_C 1.287 0.92
178_K 367_G 1.286 0.92
686_K 786_A 1.282 0.92
238_E 269_M 1.28 0.92
137_D 140_R 1.278 0.92
278_I 289_V 1.277 0.92
276_V 289_V 1.269 0.92
404_F 543_M 1.268 0.92
190_N 363_T 1.267 0.92
496_L 527_I 1.266 0.91
39_I 129_M 1.266 0.91
780_P 783_Q 1.265 0.91
343_A 347_A 1.264 0.91
932_E 936_E 1.263 0.91
287_Y 291_K 1.261 0.91
21_Q 774_D 1.26 0.91
83_G 87_Q 1.255 0.91
900_E 938_K 1.253 0.91
396_A 401_D 1.249 0.91
180_R 303_F 1.247 0.91
651_F 720_T 1.245 0.91
405_V 540_T 1.245 0.91
126_T 130_R 1.244 0.90
683_Q 791_E 1.238 0.90
127_R 130_R 1.236 0.90
935_A 939_A 1.234 0.90
905_R 930_K 1.234 0.90
166_I 425_I 1.233 0.90
791_E 795_A 1.229 0.90
750_A 754_I 1.225 0.90
903_I 934_Y 1.223 0.89
493_T 496_L 1.222 0.89
200_I 219_V 1.217 0.89
831_A 835_R 1.215 0.89
394_V 417_M 1.214 0.89
385_R 422_D 1.213 0.89
889_L 949_A 1.212 0.89
437_A 447_V 1.21 0.89
568_M 614_L 1.209 0.89
642_C 757_I 1.208 0.89
289_V 292_R 1.207 0.89
64_R 755_P 1.207 0.89
262_V 289_V 1.206 0.89
206_D 214_K 1.204 0.89
893_A 949_A 1.204 0.89
217_L 261_I 1.2 0.88
12_Q 131_R 1.198 0.88
890_A 894_K 1.191 0.88
231_T 295_L 1.188 0.88
300_I 308_R 1.187 0.88
748_R 779_Q 1.186 0.87
932_E 935_A 1.186 0.87
939_A 942_I 1.183 0.87
335_L 340_A 1.182 0.87
946_A 949_A 1.176 0.87
218_V 355_E 1.176 0.87
890_A 893_A 1.174 0.87
494_D 497_R 1.172 0.87
189_E 368_D 1.17 0.87
907_E 911_A 1.168 0.86
142_R 149_L 1.162 0.86
901_G 904_S 1.16 0.86
332_F 344_V 1.157 0.86
100_K 105_Y 1.156 0.86
203_P 353_L 1.154 0.85
15_Y 24_F 1.154 0.85
57_T 61_T 1.152 0.85
91_E 114_I 1.151 0.85
191_R 371_G 1.149 0.85
645_L 708_T 1.147 0.85
76_Q 486_T 1.143 0.85
228_L 344_V 1.143 0.85
745_G 748_R 1.142 0.85
83_G 114_I 1.141 0.85
197_M 271_K 1.14 0.85
123_G 126_T 1.14 0.85
763_Q 776_I 1.14 0.85
889_L 893_A 1.139 0.84
29_D 32_Q 1.134 0.84
823_E 854_T 1.133 0.84
570_D 608_P 1.133 0.84
332_F 350_A 1.131 0.84
835_R 838_N 1.127 0.84
101_T 106_G 1.126 0.84
153_V 473_L 1.124 0.83
679_A 683_Q 1.122 0.83
677_I 707_F 1.121 0.83
168_R 439_Y 1.118 0.83
905_R 927_E 1.117 0.83
93_K 97_E 1.114 0.83
308_R 333_Q 1.113 0.83
332_F 343_A 1.113 0.83
915_F 927_E 1.111 0.82
674_D 734_G 1.109 0.82
903_I 906_I 1.108 0.82
165_L 389_L 1.108 0.82
803_A 844_L 1.106 0.82
26_P 774_D 1.102 0.82
216_Y 355_E 1.098 0.81
620_A 638_Y 1.098 0.81
938_K 942_I 1.098 0.81
36_C 487_L 1.095 0.81
79_T 126_T 1.095 0.81
227_L 252_L 1.095 0.81
83_G 91_E 1.093 0.81
536_V 539_H 1.093 0.81
201_R 218_V 1.093 0.81
204_L 214_K 1.093 0.81
250_V 275_C 1.092 0.81
235_V 246_I 1.085 0.80
105_Y 109_A 1.083 0.80
908_N 911_A 1.081 0.80
190_N 365_P 1.081 0.80
415_S 418_R 1.08 0.80
685_I 782_P 1.08 0.80
652_V 712_F 1.079 0.80
680_E 684_T 1.077 0.80
692_L 700_A 1.076 0.80
608_P 636_E 1.076 0.80
943_E 946_A 1.075 0.79
36_C 503_S 1.075 0.79
688_Y 703_I 1.073 0.79
448_G 451_E 1.07 0.79
401_D 529_D 1.068 0.79
39_I 136_V 1.067 0.79
475_T 478_S 1.065 0.79
617_T 638_Y 1.063 0.78
47_S 124_T 1.063 0.78
301_L 307_I 1.063 0.78
118_K 122_G 1.063 0.78
930_K 934_Y 1.063 0.78
55_Q 544_T 1.06 0.78
691_A 703_I 1.06 0.78
747_L 776_I 1.059 0.78
397_V 414_F 1.059 0.78
219_V 275_C 1.058 0.78
386_A 420_I 1.058 0.78
747_L 758_T 1.058 0.78
810_I 877_I 1.058 0.78
90_V 114_I 1.057 0.78
303_F 377_M 1.057 0.78
266_H 278_I 1.056 0.78
200_I 227_L 1.056 0.78
254_L 340_A 1.055 0.78
28_G 72_N 1.054 0.78
85_A 369_R 1.053 0.77
896_V 899_I 1.053 0.77
257_R 298_I 1.052 0.77
909_K 930_K 1.052 0.77
450_N 453_E 1.051 0.77
129_M 136_V 1.049 0.77
117_W 121_S 1.048 0.77
874_E 940_K 1.047 0.77
400_G 410_E 1.045 0.77
69_Q 781_F 1.045 0.77
551_E 559_K 1.044 0.77
440_D 446_Y 1.042 0.76
191_R 366_Y 1.039 0.76
732_L 736_R 1.036 0.76
678_L 741_T 1.031 0.75
850_L 853_I 1.03 0.75
17_H 759_E 1.03 0.75
630_W 635_L 1.029 0.75
734_G 738_T 1.028 0.75
896_V 942_I 1.026 0.75
339_A 343_A 1.025 0.75
895_E 937_A 1.025 0.75
448_G 454_V 1.024 0.75
922_A 926_K 1.022 0.74
33_E 66_Q 1.022 0.74
648_A 717_L 1.02 0.74
916_V 928_R 1.019 0.74
886_E 889_L 1.018 0.74
921_E 929_E 1.018 0.74
229_G 300_I 1.016 0.74
254_L 351_L 1.015 0.74
367_G 440_D 1.013 0.74
61_T 692_L 1.013 0.74
792_A 796_D 1.011 0.73
414_F 418_R 1.007 0.73
254_L 344_V 1.007 0.73
67_R 135_S 1.007 0.73
342_K 346_A 1.006 0.73
835_R 839_E 1.005 0.73
899_I 934_Y 1.004 0.73
371_G 558_S 1.002 0.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1gaxA20.90011000.171Contact Map0.726
1ffyA10.87491000.286Contact Map0.596
1ileA10.78971000.348Contact Map0.693
1wz2A20.87491000.381Contact Map0.641
1wkbA10.72561000.447Contact Map0.646
2v0cA10.7341000.453Contact Map0.686
4arcA10.73291000.456Contact Map0.662
3ziuA20.60881000.57Contact Map0.671
1rqgA10.66771000.668Contact Map0.635
2x1lA30.53521000.679Contact Map0.666
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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