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OPENSEQ.org
PROA - Gamma-glutamyl phosphate reductase
UniProt: P07004 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10767
Length: 417 (400)
Sequences: 17323
Seq/Len: 43.31
PROA
Paralog alert: 0.85 [within 20: 0.24] - ratio of genomes with paralogs
Cluster includes: ABDH ALDA ALDB ASTD BETB EUTE FEAB GABD PROA PUUC SAD
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
263_K 324_S 5.814 1.00
263_K 322_I 3.421 1.00
236_A 272_A 3.249 1.00
266_A 322_I 3.098 1.00
231_E 262_N 3.071 1.00
10_K 193_Y 2.964 1.00
231_E 264_N 2.837 1.00
270_L 320_V 2.836 1.00
36_E 81_R 2.812 1.00
154_A 157_A 2.778 1.00
164_K 170_A 2.757 1.00
240_K 276_Q 2.751 1.00
38_Q 41_I 2.74 1.00
296_A 307_E 2.628 1.00
294_L 301_V 2.572 1.00
346_T 352_A 2.568 1.00
10_K 195_D 2.442 1.00
274_S 278_A 2.43 1.00
354_R 358_E 2.372 1.00
326_L 354_R 2.251 1.00
326_L 351_N 2.183 1.00
31_I 159_I 2.171 1.00
34_E 165_S 2.152 1.00
39_S 74_K 2.107 1.00
7_I 193_Y 2.106 1.00
27_V 168_L 2.048 1.00
260_L 329_A 2.042 1.00
259_L 318_L 2.026 1.00
110_V 406_K 2.026 1.00
337_G 383_E 2.025 1.00
227_I 242_I 2.022 1.00
268_S 272_A 2.005 1.00
271_P 275_K 2.002 1.00
34_E 37_A 1.985 1.00
186_E 190_M 1.945 1.00
33_D 37_A 1.943 1.00
41_I 154_A 1.941 1.00
109_R 403_T 1.937 1.00
232_S 351_N 1.921 1.00
34_E 158_V 1.899 1.00
207_K 383_E 1.893 1.00
324_S 328_D 1.891 1.00
260_L 332_H 1.866 1.00
307_E 311_D 1.863 1.00
190_M 212_Q 1.859 1.00
267_D 322_I 1.853 1.00
266_A 270_L 1.829 1.00
13_S 17_A 1.824 1.00
80_V 131_S 1.796 1.00
327_D 358_E 1.791 1.00
208_L 211_E 1.782 1.00
29_E 81_R 1.779 1.00
360_D 382_A 1.778 1.00
309_Y 321_K 1.76 1.00
342_D 361_S 1.759 1.00
40_E 70_P 1.754 1.00
328_D 331_A 1.753 1.00
156_V 175_A 1.744 1.00
231_E 351_N 1.743 1.00
276_Q 279_E 1.734 1.00
40_E 44_N 1.73 1.00
20_S 23_E 1.717 1.00
241_V 345_L 1.713 1.00
45_A 154_A 1.713 1.00
139_A 172_A 1.681 1.00
30_K 33_D 1.677 1.00
268_S 271_P 1.676 1.00
262_N 323_V 1.676 1.00
3_E 7_I 1.666 1.00
262_N 325_D 1.652 1.00
33_D 81_R 1.641 1.00
388_T 392_H 1.62 1.00
34_E 166_C 1.615 1.00
235_I 272_A 1.613 1.00
18_Q 358_E 1.586 1.00
23_E 26_R 1.585 1.00
230_D 351_N 1.577 1.00
247_T 277_M 1.577 1.00
242_I 269_F 1.572 1.00
330_I 355_F 1.548 1.00
109_R 400_E 1.532 1.00
325_D 328_D 1.529 1.00
261_V 269_F 1.522 1.00
272_A 275_K 1.506 1.00
13_S 139_A 1.488 1.00
44_N 289_A 1.484 1.00
38_Q 165_S 1.48 1.00
275_K 279_E 1.48 1.00
3_E 191_D 1.474 1.00
239_L 272_A 1.47 1.00
275_K 278_A 1.45 1.00
3_E 187_M 1.448 1.00
293_Q 313_F 1.445 1.00
108_R 357_N 1.432 1.00
42_I 154_A 1.43 1.00
36_E 77_A 1.416 1.00
44_N 48_Q 1.415 1.00
210_R 386_V 1.412 1.00
6_G 191_D 1.412 1.00
117_V 140_V 1.407 0.99
242_I 259_L 1.406 0.99
327_D 354_R 1.4 0.99
328_D 332_H 1.395 0.99
227_I 256_V 1.385 0.99
230_D 323_V 1.369 0.99
287_D 290_A 1.36 0.99
7_I 11_Q 1.356 0.99
126_T 142_L 1.35 0.99
92_Q 397_M 1.343 0.99
260_L 323_V 1.34 0.99
19_L 23_E 1.338 0.99
80_V 127_V 1.337 0.99
31_I 158_V 1.332 0.99
47_A 61_A 1.322 0.99
30_K 34_E 1.321 0.99
47_A 288_A 1.303 0.99
196_M 218_I 1.302 0.99
159_I 173_V 1.298 0.99
208_L 212_Q 1.298 0.99
269_F 273_L 1.293 0.99
228_Y 329_A 1.291 0.99
230_D 355_F 1.29 0.99
32_A 36_E 1.284 0.99
42_I 158_V 1.281 0.99
323_V 332_H 1.278 0.99
38_Q 154_A 1.274 0.99
397_M 400_E 1.27 0.99
108_R 408_I 1.26 0.99
356_V 408_I 1.259 0.99
117_V 198_I 1.259 0.99
310_D 335_E 1.258 0.99
92_Q 396_P 1.246 0.98
38_Q 158_V 1.24 0.98
8_A 171_G 1.238 0.98
273_L 318_L 1.238 0.98
157_A 165_S 1.237 0.98
156_V 173_V 1.236 0.98
297_G 307_E 1.235 0.98
330_I 358_E 1.229 0.98
310_D 337_G 1.228 0.98
109_R 405_Y 1.226 0.98
330_I 334_R 1.223 0.98
342_D 364_V 1.215 0.98
270_L 274_S 1.212 0.98
205_L 208_L 1.21 0.98
326_L 355_F 1.204 0.98
228_Y 355_F 1.203 0.98
329_A 332_H 1.199 0.98
130_A 173_V 1.199 0.98
265_I 268_S 1.192 0.98
396_P 400_E 1.191 0.98
39_S 70_P 1.189 0.98
267_D 271_P 1.189 0.98
19_L 27_V 1.183 0.98
6_G 193_Y 1.176 0.98
348_D 351_N 1.174 0.98
171_G 174_Q 1.164 0.97
31_I 168_L 1.164 0.97
106_E 353_Q 1.164 0.97
8_A 174_Q 1.162 0.97
31_I 80_V 1.152 0.97
187_M 191_D 1.151 0.97
14_Y 331_A 1.148 0.97
210_R 217_V 1.141 0.97
230_D 262_N 1.136 0.97
352_A 366_V 1.136 0.97
267_D 270_L 1.135 0.97
146_K 182_A 1.135 0.97
262_N 265_I 1.133 0.97
29_E 85_N 1.131 0.97
293_Q 296_A 1.119 0.96
226_H 342_D 1.117 0.96
237_E 347_R 1.115 0.96
106_E 410_I 1.114 0.96
146_K 180_D 1.107 0.96
278_A 302_V 1.106 0.96
180_D 183_L 1.105 0.96
327_D 331_A 1.104 0.96
202_G 205_L 1.103 0.96
232_S 348_D 1.102 0.96
195_D 360_D 1.099 0.96
186_E 212_Q 1.095 0.96
397_M 405_Y 1.091 0.96
116_G 194_I 1.084 0.96
112_L 138_N 1.084 0.96
227_I 345_L 1.077 0.95
153_A 177_D 1.068 0.95
4_Q 8_A 1.067 0.95
234_E 347_R 1.066 0.95
234_E 237_E 1.062 0.95
204_G 208_L 1.06 0.95
230_D 326_L 1.059 0.95
11_Q 14_Y 1.056 0.95
114_V 194_I 1.052 0.95
37_A 165_S 1.05 0.94
207_K 211_E 1.044 0.94
130_A 140_V 1.043 0.94
14_Y 18_Q 1.036 0.94
235_I 239_L 1.034 0.94
229_V 269_F 1.034 0.94
239_L 276_Q 1.031 0.94
122_R 252_T 1.031 0.94
21_S 25_N 1.029 0.94
186_E 208_L 1.028 0.94
38_Q 157_A 1.026 0.94
127_V 155_T 1.024 0.93
44_N 58_L 1.021 0.93
29_E 33_D 1.018 0.93
32_A 81_R 1.011 0.93
245_A 256_V 1.009 0.93
110_V 357_N 1.007 0.93
48_Q 289_A 1.006 0.93
41_I 44_N 1.005 0.93
210_R 214_T 1.005 0.93
12_A 139_A 1.001 0.92
216_P 404_T 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3ek1A80.93051000.048Contact Map0.801
4ghkA40.99761000.048Contact Map0.666
1a4sA40.93291000.051Contact Map0.783
3k2wA80.93761000.055Contact Map0.855
1bxsA40.93531000.055Contact Map0.794
4f3xA40.92811000.056Contact Map0.725
1o04A80.93531000.056Contact Map0.799
4i8pA20.94241000.056Contact Map0.785
3ed6A20.93761000.057Contact Map0.764
3u4jA40.93761000.059Contact Map0.798
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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