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OPENSEQ.org
HISX - Histidinol dehydrogenase
UniProt: P06988 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10447
Length: 434 (423)
Sequences: 1736
Seq/Len: 4.10
HISX
Paralog alert: 0.05 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
42_N 46_R 4.62 1.00
46_R 53_E 3.7 1.00
40_L 191_A 3.655 1.00
67_K 180_D 3.539 1.00
56_A 62_T 3.48 1.00
126_S 156_K 3.26 1.00
160_C 193_L 3.225 1.00
242_I 320_S 3.113 1.00
96_E 100_T 3.104 1.00
129_L 146_A 3.052 1.00
334_N 337_E 3.004 1.00
314_A 341_S 2.975 1.00
135_S 264_P 2.936 1.00
95_I 143_L 2.904 1.00
156_K 180_D 2.874 1.00
42_N 54_Y 2.818 1.00
250_D 284_A 2.706 1.00
295_A 299_R 2.69 1.00
317_V 342_I 2.669 1.00
150_S 179_Q 2.575 1.00
336_R 394_E 2.557 1.00
275_A 279_R 2.439 1.00
245_S 274_A 2.353 1.00
404_A 427_V 2.331 1.00
412_A 424_T 2.323 1.00
278_A 307_L 2.289 1.00
311_K 315_Q 2.284 1.00
48_D 197_T 2.219 1.00
90_V 406_T 2.197 1.00
35_T 213_F 2.145 1.00
216_E 220_Q 2.138 1.00
46_R 49_E 2.123 1.00
412_A 417_T 2.103 1.00
77_S 174_Q 2.084 1.00
239_V 258_S 2.07 1.00
146_A 178_V 2.069 1.00
284_A 287_R 2.052 1.00
357_S 422_A 2.027 1.00
74_A 174_Q 2.027 1.00
240_L 320_S 2.021 1.00
73_I 181_V 2.014 1.00
89_A 175_L 1.995 1.00
67_K 182_F 1.989 1.00
155_K 343_T 1.98 1.00
263_G 266_S 1.962 1.00
310_T 316_C 1.958 1.00
122_R 390_M 1.957 1.00
125_A 343_T 1.948 1.00
125_A 155_K 1.93 1.00
272_T 278_A 1.912 1.00
421_N 424_T 1.907 1.00
92_V 96_E 1.894 1.00
335_A 350_L 1.883 1.00
41_D 45_A 1.871 1.00
53_E 57_K 1.853 1.00
204_D 376_A 1.841 1.00
408_E 424_T 1.834 1.00
182_F 201_P 1.825 1.00
74_A 78_E 1.82 1.00
158_V 193_L 1.806 1.00
278_A 309_V 1.797 1.00
38_D 42_N 1.769 0.99
215_T 233_P 1.739 0.99
276_D 280_R 1.739 0.99
124_V 205_K 1.733 0.99
125_A 344_S 1.709 0.99
42_N 53_E 1.687 0.99
292_L 298_A 1.678 0.99
92_V 147_T 1.676 0.99
289_L 298_A 1.674 0.99
85_K 89_A 1.673 0.99
96_E 150_S 1.66 0.99
70_A 74_A 1.634 0.99
143_L 147_T 1.629 0.99
282_A 307_L 1.609 0.99
254_S 288_Q 1.606 0.99
159_L 173_A 1.6 0.99
317_V 338_L 1.575 0.98
246_G 333_R 1.563 0.98
397_K 401_S 1.557 0.98
72_E 183_N 1.544 0.98
157_V 179_Q 1.536 0.98
250_D 287_R 1.534 0.98
320_S 325_P 1.528 0.98
245_S 273_P 1.524 0.98
293_P 417_T 1.522 0.98
71_E 75_A 1.518 0.98
273_P 310_T 1.518 0.98
286_E 299_R 1.518 0.98
49_E 198_E 1.508 0.98
358_A 407_I 1.504 0.98
127_V 205_K 1.504 0.98
330_I 342_I 1.499 0.98
195_F 221_V 1.481 0.97
108_D 116_R 1.463 0.97
363_S 393_Q 1.458 0.97
284_A 288_Q 1.45 0.97
271_L 319_I 1.444 0.97
79_R 167_D 1.443 0.97
248_T 429_A 1.438 0.97
242_I 316_C 1.436 0.97
128_G 193_L 1.435 0.97
142_V 159_L 1.431 0.97
158_V 180_D 1.426 0.97
332_T 338_L 1.414 0.96
84_L 413_A 1.391 0.96
408_E 412_A 1.389 0.96
384_A 389_R 1.389 0.96
184_V 200_V 1.388 0.96
70_A 174_Q 1.383 0.96
48_D 199_S 1.37 0.95
69_S 72_E 1.366 0.95
68_V 170_L 1.361 0.95
33_T 220_Q 1.349 0.95
290_A 295_A 1.347 0.95
52_R 66_L 1.346 0.95
68_V 183_N 1.343 0.95
400_F 423_V 1.336 0.95
171_Y 174_Q 1.333 0.94
87_A 410_L 1.329 0.94
241_V 256_L 1.328 0.94
37_N 220_Q 1.322 0.94
344_S 388_K 1.315 0.94
77_S 171_Y 1.307 0.94
85_K 171_Y 1.306 0.94
88_M 175_L 1.304 0.94
82_D 86_Q 1.302 0.94
43_V 191_A 1.295 0.93
212_A 216_E 1.294 0.93
348_V 390_M 1.29 0.93
160_C 189_A 1.286 0.93
104_L 384_A 1.282 0.93
92_V 143_L 1.268 0.92
141_T 145_L 1.266 0.92
280_R 283_E 1.249 0.92
36_V 216_E 1.229 0.91
252_V 281_V 1.225 0.91
75_A 79_R 1.221 0.90
249_P 280_R 1.219 0.90
288_Q 421_N 1.215 0.90
51_L 184_V 1.213 0.90
76_A 170_L 1.212 0.90
87_A 409_T 1.208 0.90
277_M 281_V 1.205 0.90
408_E 420_K 1.199 0.89
242_I 330_I 1.194 0.89
312_D 315_Q 1.188 0.89
252_V 277_M 1.187 0.89
243_A 277_M 1.185 0.88
10_N 13_T 1.183 0.88
75_A 78_E 1.172 0.88
116_R 394_E 1.163 0.87
205_K 385_D 1.158 0.87
273_P 313_L 1.148 0.86
161_S 165_I 1.143 0.86
362_A 407_I 1.14 0.86
92_V 175_L 1.136 0.85
145_L 368_V 1.133 0.85
141_T 368_V 1.13 0.85
49_E 53_E 1.129 0.85
156_K 182_F 1.126 0.85
270_L 281_V 1.124 0.85
331_Q 352_D 1.12 0.84
283_E 287_R 1.12 0.84
258_S 357_S 1.12 0.84
129_L 157_V 1.117 0.84
353_W 397_K 1.114 0.84
384_A 387_Q 1.104 0.83
172_A 176_C 1.102 0.83
339_V 392_V 1.101 0.83
257_L 298_A 1.099 0.83
97_T 100_T 1.09 0.82
412_A 420_K 1.084 0.82
243_A 247_A 1.075 0.81
150_S 176_C 1.07 0.80
122_R 343_T 1.065 0.80
84_L 168_E 1.064 0.80
124_V 127_V 1.062 0.80
34_R 38_D 1.062 0.80
245_S 333_R 1.061 0.80
80_L 85_K 1.06 0.80
420_K 424_T 1.041 0.78
11_S 315_Q 1.035 0.77
67_K 156_K 1.035 0.77
362_A 406_T 1.031 0.77
40_L 44_K 1.028 0.77
68_V 76_A 1.028 0.77
221_V 228_A 1.027 0.77
194_A 221_V 1.027 0.77
256_L 285_V 1.024 0.76
70_A 179_Q 1.015 0.75
135_S 294_R 1.012 0.75
347_S 392_V 1.01 0.75
42_N 57_K 1.004 0.74
272_T 307_L 1.004 0.74
88_M 410_L 1.001 0.74
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1kaeA20.99311000.029Contact Map0.767
4g07A10.98161000.036Contact Map0.672
4g09A10.98161000.036Contact Map0.66
4gicA20.94931000.058Contact Map0.784
4itaA20.794997.30.956Contact Map0.361
4h7nA40.843397.20.957Contact Map0.519
3my7A40.794997.10.957Contact Map0.392
4ghkA40.797296.90.958Contact Map0.371
3etfA40.797296.90.959Contact Map0.39
3v4cA20.859496.90.959Contact Map0.382
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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