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OPENSEQ.org

TTDA - L(+)-tartrate dehydratase subunit alpha
UniProt: P05847 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11168
Length: 303 (289)
Sequences: 887
Seq/Len: 3.07

TTDA
Paralog alert: 0.34 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
82_K 146_E 3.386 1.00
19_A 107_K 2.918 1.00
81_V 97_L 2.893 1.00
175_V 233_R 2.769 1.00
158_L 268_T 2.701 1.00
61_Q 65_D 2.649 1.00
35_D 39_Q 2.559 1.00
154_G 268_T 2.543 1.00
19_A 103_E 2.536 1.00
99_Q 102_E 2.501 1.00
18_V 97_L 2.392 1.00
180_E 184_T 2.314 1.00
154_G 264_R 2.223 1.00
17_I 285_L 2.144 1.00
210_S 274_S 2.134 1.00
121_V 124_G 2.133 1.00
144_D 286_L 2.112 1.00
45_T 251_N 2.105 1.00
99_Q 103_E 2.093 1.00
38_K 42_D 2.05 1.00
15_T 103_E 2.041 1.00
94_Q 98_K 2.004 1.00
102_E 125_K 1.983 1.00
95_S 98_K 1.947 1.00
32_D 216_R 1.925 0.99
8_Q 90_L 1.902 0.99
189_A 193_V 1.896 0.99
89_L 145_A 1.888 0.99
15_T 99_Q 1.809 0.99
31_D 35_D 1.788 0.99
179_F 234_L 1.769 0.99
197_V 273_V 1.76 0.99
146_E 284_T 1.757 0.99
179_F 237_G 1.755 0.99
236_E 239_N 1.745 0.99
219_G 258_H 1.735 0.99
41_K 54_H 1.664 0.98
234_L 238_L 1.662 0.98
94_Q 138_I 1.643 0.98
176_K 180_E 1.641 0.98
39_Q 43_A 1.633 0.98
46_S 49_G 1.628 0.98
236_E 240_R 1.586 0.97
195_V 238_L 1.579 0.97
148_E 284_T 1.559 0.97
150_Y 215_L 1.545 0.97
227_A 259_I 1.543 0.97
79_F 97_L 1.533 0.96
22_T 77_I 1.521 0.96
103_E 107_K 1.518 0.96
76_E 154_G 1.502 0.96
22_T 104_A 1.502 0.96
197_V 259_I 1.497 0.96
164_V 271_V 1.483 0.95
14_L 147_I 1.478 0.95
216_R 260_E 1.449 0.95
24_M 28_R 1.445 0.95
101_V 133_W 1.435 0.94
79_F 149_V 1.432 0.94
34_V 64_I 1.43 0.94
178_V 234_L 1.425 0.94
166_M 169_E 1.393 0.93
276_G 280_H 1.38 0.93
16_E 103_E 1.379 0.93
237_G 241_L 1.368 0.92
91_G 96_I 1.367 0.92
16_E 20_N 1.365 0.92
288_H 293_F 1.363 0.92
117_I 131_V 1.36 0.92
235_E 254_V 1.351 0.92
81_V 136_W 1.344 0.91
162_S 207_A 1.339 0.91
221_R 232_L 1.336 0.91
206_A 272_A 1.327 0.91
222_H 227_A 1.322 0.90
195_V 254_V 1.304 0.90
175_V 237_G 1.303 0.90
230_L 259_I 1.293 0.89
28_R 64_I 1.293 0.89
81_V 147_I 1.283 0.89
76_E 114_A 1.279 0.88
12_N 16_E 1.259 0.87
122_N 125_K 1.25 0.87
212_K 260_E 1.248 0.87
77_I 105_T 1.242 0.86
119_D 226_K 1.239 0.86
135_T 140_P 1.232 0.86
160_G 207_A 1.231 0.86
181_N 184_T 1.231 0.86
79_F 101_V 1.221 0.85
70_A 279_A 1.215 0.85
77_I 149_V 1.214 0.85
160_G 206_A 1.204 0.84
14_L 97_L 1.201 0.84
226_K 229_E 1.199 0.84
39_Q 42_D 1.178 0.82
120_E 125_K 1.178 0.82
82_K 138_I 1.174 0.82
22_T 149_V 1.168 0.81
92_E 95_S 1.164 0.81
195_V 275_T 1.163 0.81
167_P 233_R 1.162 0.81
114_A 154_G 1.154 0.80
87_F 145_A 1.151 0.80
43_A 252_S 1.151 0.80
166_M 173_G 1.149 0.80
237_G 240_R 1.148 0.80
161_R 184_T 1.13 0.78
209_L 260_E 1.13 0.78
122_N 130_G 1.123 0.78
33_V 37_L 1.118 0.77
165_L 173_G 1.116 0.77
258_H 268_T 1.107 0.76
205_T 262_A 1.105 0.76
202_S 205_T 1.102 0.76
79_F 230_L 1.1 0.76
49_G 251_N 1.098 0.75
58_D 61_Q 1.096 0.75
78_M 204_E 1.088 0.75
245_P 252_S 1.086 0.74
225_P 229_E 1.081 0.74
246_Q 276_G 1.066 0.72
194_L 218_I 1.059 0.72
204_E 208_V 1.055 0.71
203_V 207_A 1.053 0.71
76_E 264_R 1.052 0.71
209_L 212_K 1.049 0.71
81_V 93_L 1.045 0.70
161_R 181_N 1.042 0.70
175_V 230_L 1.036 0.69
11_V 89_L 1.034 0.69
41_K 50_K 1.031 0.69
154_G 258_H 1.025 0.68
238_L 254_V 1.024 0.68
218_I 256_G 1.023 0.68
29_M 214_I 1.019 0.67
221_R 256_G 1.014 0.67
31_D 36_K 1.012 0.67
25_I 151_M 1.01 0.66
78_M 136_W 1.007 0.66
50_K 124_G 1.004 0.66
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results:
PDB Chains Cov P(%) HHΔ   Acc
2jliA10.29735.50.971Contact Map0.296
3bzsA10.353125.20.974Contact Map0.286
2jljA10.369619.70.975Contact Map0.321
3b1sB30.260718.30.975Contact Map0.418
3t7yA20.29716.80.976Contact Map0.138
2qv6A40.716215.50.976Contact Map0.295
3qoqA40.217815.30.976Contact Map0.474
1x93A20.181513.90.977Contact Map0.231
3zboA20.234313.60.977Contact Map0.326
2q22A30.415813.40.977Contact Map0.195

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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