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OPENSEQ.org
RECN - DNA repair protein RecN
UniProt: P05824 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10831
Length: 553 (552)
Sequences: 1695
Seq/Len: 3.07
RECN
Paralog alert: 0.01 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
213_E 297_R 6.175 1.00
186_R 332_E 4.378 1.00
177_Q 347_A 3.997 1.00
522_N 525_A 3.519 1.00
210_I 301_L 3.314 1.00
465_I 473_V 3.17 1.00
198_N 330_L 2.925 1.00
397_V 410_D 2.787 1.00
206_E 304_R 2.671 1.00
45_C 66_A 2.648 1.00
528_Q 544_L 2.603 1.00
187_A 333_Q 2.587 1.00
198_N 326_Y 2.564 1.00
393_F 414_F 2.518 1.00
242_L 249_A 2.517 1.00
197_L 322_L 2.51 1.00
466_S 533_L 2.48 1.00
107_I 120_L 2.454 1.00
200_F 307_K 2.378 1.00
204_P 320_E 2.366 1.00
318_S 321_A 2.359 1.00
365_H 409_A 2.339 1.00
365_H 369_Q 2.315 1.00
519_Q 525_A 2.314 1.00
194_L 326_Y 2.279 1.00
159_M 357_A 2.206 1.00
260_D 287_Y 2.157 1.00
354_H 358_L 2.128 1.00
55_V 99_S 2.089 1.00
169_S 350_V 2.088 1.00
26_V 502_H 2.071 1.00
395_I 414_F 2.055 1.00
162_R 353_H 2.041 1.00
173_L 350_V 1.993 1.00
169_S 353_H 1.991 1.00
542_N 549_E 1.981 1.00
347_A 351_T 1.98 1.00
191_Q 337_D 1.938 1.00
150_A 371_Y 1.93 0.99
272_E 276_Q 1.923 0.99
326_Y 330_L 1.917 0.99
187_A 191_Q 1.9 0.99
418_T 430_V 1.891 0.99
246_L 277_I 1.887 0.99
216_R 260_D 1.886 0.99
169_S 173_L 1.882 0.99
165_L 349_A 1.864 0.99
202_P 308_Q 1.834 0.99
203_Q 209_Q 1.832 0.99
169_S 172_D 1.829 0.99
159_M 364_L 1.826 0.99
357_A 404_L 1.796 0.99
269_M 276_Q 1.774 0.99
535_G 543_T 1.763 0.99
200_F 311_L 1.759 0.99
26_V 499_G 1.736 0.99
196_E 314_K 1.73 0.99
194_L 333_Q 1.728 0.99
195_K 199_E 1.722 0.99
504_F 521_L 1.707 0.98
220_S 291_L 1.706 0.98
172_D 342_S 1.698 0.98
269_M 279_E 1.698 0.98
242_L 246_L 1.696 0.98
42_L 457_I 1.69 0.98
207_F 312_A 1.675 0.98
324_Q 328_S 1.669 0.98
474_G 498_C 1.659 0.98
173_L 347_A 1.657 0.98
524_K 548_K 1.649 0.98
57_T 423_P 1.647 0.98
268_D 272_E 1.636 0.98
155_L 367_Q 1.635 0.98
61_R 96_V 1.629 0.98
506_S 519_Q 1.627 0.98
156_L 160_T 1.62 0.98
316_H 322_L 1.62 0.98
370_Q 377_Q 1.611 0.98
173_L 343_Q 1.595 0.97
266_V 280_A 1.593 0.97
205_G 208_E 1.589 0.97
170_C 350_V 1.582 0.97
214_Y 301_L 1.58 0.97
249_A 270_L 1.573 0.97
422_Q 513_M 1.568 0.97
270_L 280_A 1.566 0.97
349_A 353_H 1.559 0.97
374_E 378_L 1.55 0.97
396_D 415_R 1.546 0.97
162_R 360_I 1.545 0.97
376_A 395_I 1.539 0.97
327_Q 331_E 1.538 0.97
297_R 300_E 1.509 0.96
361_A 409_A 1.49 0.96
529_E 532_R 1.485 0.96
165_L 169_S 1.48 0.95
189_L 193_Q 1.477 0.95
356_Q 360_I 1.476 0.95
324_Q 327_Q 1.47 0.95
172_D 349_A 1.467 0.95
394_T 424_M 1.466 0.95
273_A 280_A 1.465 0.95
143_K 412_I 1.461 0.95
351_T 354_H 1.458 0.95
227_S 287_Y 1.456 0.95
526_R 551_L 1.451 0.95
470_A 492_L 1.449 0.95
317_V 321_A 1.448 0.95
44_L 50_A 1.444 0.95
221_G 225_T 1.439 0.94
213_E 301_L 1.436 0.94
185_A 188_E 1.433 0.94
365_H 410_D 1.417 0.94
328_S 332_E 1.414 0.94
345_T 349_A 1.411 0.94
392_Q 417_T 1.405 0.93
527_L 548_K 1.402 0.93
223_L 260_D 1.391 0.93
205_G 320_E 1.389 0.93
370_Q 374_E 1.388 0.93
143_K 407_D 1.387 0.93
229_N 252_L 1.386 0.93
191_Q 195_K 1.383 0.93
194_L 330_L 1.383 0.93
4_Q 19_D 1.374 0.92
317_V 322_L 1.37 0.92
155_L 360_I 1.363 0.92
10_F 54_M 1.362 0.92
319_P 322_L 1.357 0.92
128_H 440_A 1.356 0.92
52_A 55_V 1.353 0.92
43_G 48_G 1.347 0.91
130_Q 433_G 1.34 0.91
142_Q 395_I 1.331 0.91
308_Q 323_P 1.329 0.91
387_S 469_T 1.319 0.90
363_A 370_Q 1.319 0.90
214_Y 302_E 1.317 0.90
174_A 178_Q 1.315 0.90
170_C 174_A 1.313 0.90
14_R 515_E 1.312 0.90
155_L 363_A 1.311 0.90
168_Q 172_D 1.309 0.90
398_K 411_R 1.306 0.90
348_L 352_K 1.306 0.90
383_M 391_G 1.302 0.90
169_S 349_A 1.301 0.89
158_E 360_I 1.301 0.89
297_R 301_L 1.299 0.89
126_Q 444_Q 1.297 0.89
376_A 394_T 1.291 0.89
421_G 514_T 1.29 0.89
155_L 158_E 1.288 0.89
478_R 500_H 1.287 0.89
315_H 329_L 1.285 0.89
10_F 41_A 1.282 0.89
223_L 287_Y 1.278 0.88
63_D 94_R 1.275 0.88
312_A 322_L 1.275 0.88
8_S 15_E 1.274 0.88
385_A 476_L 1.274 0.88
167_H 170_C 1.273 0.88
158_E 363_A 1.272 0.88
207_F 211_D 1.271 0.88
508_E 517_H 1.27 0.88
79_W 120_L 1.268 0.88
264_S 268_D 1.266 0.88
94_R 106_F 1.265 0.88
80_L 85_L 1.261 0.87
166_W 350_V 1.259 0.87
254_S 271_E 1.254 0.87
362_R 366_Q 1.253 0.87
296_N 299_F 1.243 0.86
93_L 121_G 1.229 0.86
2_L 68_F 1.225 0.85
21_H 520_S 1.224 0.85
541_R 545_A 1.222 0.85
497_G 550_L 1.221 0.85
246_L 270_L 1.22 0.85
347_A 350_V 1.219 0.85
78_R 82_E 1.208 0.84
275_I 279_E 1.207 0.84
382_S 476_L 1.203 0.84
433_G 464_G 1.2 0.84
360_I 363_A 1.2 0.84
352_K 356_Q 1.199 0.84
217_L 297_R 1.198 0.84
360_I 364_L 1.198 0.84
173_L 177_Q 1.195 0.83
67_R 90_E 1.189 0.83
263_L 287_Y 1.187 0.83
130_Q 464_G 1.182 0.82
178_Q 182_E 1.178 0.82
355_Q 359_E 1.176 0.82
171_R 175_H 1.174 0.82
530_L 551_L 1.17 0.82
295_P 298_L 1.167 0.81
348_L 351_T 1.165 0.81
503_Y 518_M 1.153 0.80
158_E 162_R 1.153 0.80
312_A 319_P 1.152 0.80
152_E 367_Q 1.146 0.80
4_Q 17_E 1.144 0.79
165_L 356_Q 1.141 0.79
327_Q 330_L 1.14 0.79
524_K 528_Q 1.137 0.79
190_L 329_L 1.137 0.79
169_S 346_L 1.136 0.79
303_Q 307_K 1.131 0.78
190_L 332_E 1.131 0.78
397_V 412_I 1.128 0.78
131_H 134_Q 1.126 0.78
420_P 509_T 1.126 0.78
226_T 256_L 1.122 0.78
9_N 59_A 1.122 0.78
256_L 263_L 1.121 0.78
25_T 503_Y 1.113 0.77
10_F 62_A 1.109 0.76
5_L 66_A 1.106 0.76
490_T 496_A 1.101 0.76
213_E 217_L 1.099 0.76
165_L 168_Q 1.097 0.75
60_A 99_S 1.096 0.75
321_A 324_Q 1.096 0.75
242_L 245_Q 1.095 0.75
165_L 353_H 1.095 0.75
338_D 341_D 1.088 0.75
194_L 329_L 1.083 0.74
27_I 487_M 1.079 0.74
349_A 352_K 1.077 0.73
223_L 227_S 1.075 0.73
269_M 280_A 1.075 0.73
166_W 354_H 1.073 0.73
294_D 300_E 1.066 0.72
3_A 69_S 1.065 0.72
375_L 443_I 1.064 0.72
175_H 179_L 1.057 0.71
223_L 259_M 1.056 0.71
184_A 187_A 1.055 0.71
202_P 319_P 1.054 0.71
366_Q 373_E 1.051 0.71
319_P 323_P 1.051 0.71
230_A 249_A 1.05 0.71
217_L 293_L 1.048 0.71
24_M 488_C 1.042 0.70
197_L 323_P 1.042 0.70
358_L 409_A 1.041 0.70
207_F 309_I 1.041 0.70
214_Y 305_I 1.04 0.70
156_L 159_M 1.04 0.70
40_D 495_V 1.037 0.69
330_L 334_Q 1.037 0.69
105_G 112_V 1.035 0.69
265_G 268_D 1.035 0.69
143_K 397_V 1.034 0.69
158_E 161_A 1.032 0.69
413_E 428_A 1.032 0.69
342_S 345_T 1.031 0.69
543_T 550_L 1.029 0.69
6_T 15_E 1.028 0.68
46_L 125_I 1.025 0.68
273_A 277_I 1.024 0.68
18_I 518_M 1.021 0.68
325_Y 329_L 1.021 0.68
54_M 97_I 1.021 0.68
139_P 413_E 1.02 0.68
375_L 393_F 1.019 0.67
87_D 90_E 1.016 0.67
466_S 546_N 1.014 0.67
96_V 106_F 1.01 0.66
543_T 549_E 1.009 0.66
532_R 546_N 1.006 0.66
16_L 37_I 1.004 0.66
44_L 534_L 1.003 0.66
192_Y 196_E 1.001 0.65
468_P 471_A 1.001 0.65
12_I 39_I 1 0.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4ad8A10.86441000.469Contact Map0.554
4abyA40.67991000.605Contact Map0.686
1w1wA40.71971000.651Contact Map0.627
3zgxA20.72691000.665Contact Map0.417
3auyA20.64921000.732Contact Map0.577
4i99A20.58771000.8Contact Map0.781
4abxA40.31651000.806Contact Map0.634
2o5vA10.61661000.816Contact Map0.436
3qktA40.580599.90.864Contact Map0.735
3qf7A20.614899.80.878Contact Map0.73
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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