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OPENSEQ.org
EX5A - Exodeoxyribonuclease V alpha chain
UniProt: P04993 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10826
Length: 608 (598)
Sequences: 1055
Seq/Len: 1.76
EX5A
Paralog alert: 0.05 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
374_I 570_V 4.525 1.00
168_V 313_I 4.476 1.00
263_L 266_L 4.244 1.00
377_G 563_R 3.94 1.00
551_L 569_A 3.655 1.00
271_A 274_I 3.383 1.00
287_P 290_A 3.143 1.00
54_P 597_R 3.027 1.00
119_V 276_L 3.006 1.00
181_V 212_L 2.859 1.00
200_R 263_L 2.652 1.00
274_I 279_M 2.645 1.00
538_V 551_L 2.363 1.00
119_V 283_I 2.289 1.00
437_E 547_D 2.284 1.00
482_V 510_V 2.16 0.99
167_S 353_C 2.083 0.99
268_V 282_L 2.066 0.99
482_V 530_H 2.043 0.99
547_D 575_R 2.043 0.99
266_L 287_P 1.931 0.98
491_L 526_R 1.876 0.98
314_C 352_L 1.869 0.98
123_F 337_V 1.868 0.98
480_R 532_T 1.868 0.98
279_M 283_I 1.852 0.97
123_F 292_V 1.848 0.97
596_R 600_L 1.837 0.97
240_L 278_M 1.809 0.97
299_D 375_N 1.798 0.97
142_D 155_K 1.737 0.96
211_R 214_E 1.732 0.96
510_V 530_H 1.718 0.95
202_A 243_L 1.674 0.95
566_V 589_A 1.653 0.94
245_G 255_H 1.651 0.94
365_S 392_D 1.647 0.94
45_D 53_L 1.644 0.94
440_L 458_I 1.637 0.94
108_Y 603_L 1.62 0.93
511_W 517_G 1.616 0.93
266_L 286_L 1.611 0.93
61_N 66_P 1.606 0.93
240_L 274_I 1.59 0.92
271_A 279_M 1.584 0.92
583_E 587_S 1.579 0.92
118_T 280_S 1.574 0.92
246_A 253_L 1.57 0.92
197_C 265_V 1.557 0.91
415_Y 550_A 1.528 0.90
122_F 125_E 1.527 0.90
378_D 381_A 1.525 0.90
200_R 266_L 1.499 0.89
160_V 167_S 1.495 0.89
445_R 531_E 1.477 0.88
587_S 591_A 1.471 0.88
119_V 279_M 1.469 0.88
464_Q 477_Y 1.469 0.88
216_L 569_A 1.469 0.88
255_H 259_N 1.457 0.87
155_K 159_A 1.456 0.87
158_A 183_K 1.455 0.87
279_M 313_I 1.452 0.87
227_D 230_K 1.446 0.87
197_C 264_D 1.445 0.87
438_Y 550_A 1.436 0.86
188_L 265_V 1.427 0.86
255_H 260_P 1.407 0.85
283_I 292_V 1.407 0.85
169_I 180_T 1.399 0.84
412_L 461_F 1.398 0.84
476_W 501_A 1.386 0.83
445_R 485_A 1.381 0.83
124_N 604_F 1.381 0.83
48_E 61_N 1.37 0.82
115_N 280_S 1.369 0.82
173_P 241_H 1.362 0.82
458_I 547_D 1.361 0.82
134_E 331_R 1.359 0.82
541_S 574_R 1.342 0.81
545_E 574_R 1.335 0.80
501_A 510_V 1.332 0.80
51_V 108_Y 1.326 0.79
256_H 260_P 1.326 0.79
557_R 592_T 1.322 0.79
415_Y 435_F 1.318 0.79
112_M 277_P 1.312 0.78
488_D 491_L 1.31 0.78
271_A 294_F 1.303 0.78
115_N 277_P 1.298 0.77
483_M 536_M 1.295 0.77
117_R 603_L 1.289 0.77
103_C 603_L 1.289 0.77
202_A 276_L 1.289 0.77
337_V 602_A 1.284 0.76
167_S 293_I 1.283 0.76
22_Q 170_S 1.281 0.76
537_T 562_T 1.27 0.75
601_A 605_S 1.262 0.75
165_R 291_R 1.26 0.74
51_V 276_L 1.258 0.74
154_Q 157_A 1.258 0.74
263_L 290_A 1.253 0.74
137_L 162_L 1.253 0.74
144_L 187_A 1.248 0.73
313_I 530_H 1.248 0.73
51_V 448_P 1.238 0.73
315_A 601_A 1.234 0.72
200_R 261_L 1.232 0.72
133_D 136_L 1.231 0.72
204_P 497_D 1.23 0.72
112_M 115_N 1.223 0.71
400_S 403_D 1.222 0.71
77_E 80_N 1.217 0.71
286_L 290_A 1.208 0.70
111_R 277_P 1.207 0.70
275_D 545_E 1.207 0.70
481_P 498_I 1.197 0.69
182_A 186_A 1.196 0.69
143_K 190_Q 1.195 0.69
142_D 146_P 1.192 0.68
553_L 579_L 1.188 0.68
169_I 293_I 1.186 0.68
101_I 110_N 1.186 0.68
173_P 204_P 1.185 0.68
42_L 53_L 1.184 0.68
35_V 88_S 1.18 0.67
243_L 285_A 1.175 0.67
263_L 287_P 1.175 0.67
9_E 12_E 1.173 0.67
138_A 159_A 1.172 0.66
140_T 187_A 1.168 0.66
324_E 327_R 1.166 0.66
536_M 541_S 1.166 0.66
168_V 352_L 1.164 0.66
286_L 289_H 1.163 0.66
441_L 538_V 1.162 0.66
173_P 541_S 1.161 0.65
52_C 106_R 1.158 0.65
445_R 451_V 1.154 0.65
298_R 354_L 1.151 0.64
359_Y 557_R 1.15 0.64
538_V 569_A 1.147 0.64
151_I 357_K 1.145 0.64
112_M 306_A 1.143 0.64
178_T 512_F 1.142 0.64
442_C 451_V 1.14 0.63
245_G 254_R 1.139 0.63
85_L 595_E 1.136 0.63
548_H 576_R 1.134 0.63
173_P 497_D 1.134 0.63
120_A 600_L 1.133 0.63
375_N 559_P 1.132 0.63
179_T 275_D 1.132 0.63
50_H 53_L 1.13 0.62
109_L 306_A 1.128 0.62
358_S 361_F 1.124 0.62
169_I 577_L 1.122 0.62
79_Q 268_V 1.118 0.61
371_A 571_T 1.116 0.61
243_L 304_V 1.115 0.61
244_L 253_L 1.114 0.61
179_T 359_Y 1.113 0.61
170_S 354_L 1.113 0.61
253_L 310_L 1.111 0.60
390_F 534_W 1.109 0.60
298_R 375_N 1.108 0.60
499_G 540_K 1.108 0.60
173_P 299_D 1.107 0.60
268_V 294_F 1.106 0.60
278_M 385_V 1.106 0.60
276_L 537_T 1.099 0.59
212_L 290_A 1.098 0.59
175_T 483_M 1.098 0.59
493_L 522_V 1.094 0.59
65_H 81_W 1.093 0.59
25_L 29_G 1.092 0.58
509_R 521_S 1.091 0.58
52_C 188_L 1.09 0.58
169_I 356_Q 1.087 0.58
462_M 490_A 1.087 0.58
180_T 187_A 1.086 0.58
204_P 241_H 1.085 0.58
373_A 378_D 1.085 0.58
358_S 368_G 1.083 0.57
118_T 284_D 1.082 0.57
285_A 304_V 1.082 0.57
310_L 565_L 1.08 0.57
325_R 328_Q 1.079 0.57
476_W 510_V 1.077 0.57
205_T 497_D 1.076 0.57
422_L 478_E 1.075 0.57
201_L 212_L 1.075 0.57
382_V 586_L 1.074 0.56
302_A 361_F 1.074 0.56
242_R 541_S 1.074 0.56
459_E 480_R 1.071 0.56
492_G 518_N 1.071 0.56
474_S 532_T 1.068 0.56
396_R 580_Y 1.066 0.56
261_L 304_V 1.065 0.56
557_R 560_V 1.065 0.56
328_Q 332_L 1.062 0.55
483_M 531_E 1.061 0.55
173_P 304_V 1.06 0.55
370_L 393_I 1.059 0.55
205_T 241_H 1.057 0.55
498_I 536_M 1.055 0.54
179_T 439_Q 1.055 0.54
58_L 107_L 1.055 0.54
212_L 216_L 1.054 0.54
489_S 494_F 1.052 0.54
444_L 560_V 1.052 0.54
120_A 530_H 1.052 0.54
312_D 459_E 1.051 0.54
327_R 330_S 1.051 0.54
53_L 274_I 1.049 0.54
173_P 205_T 1.045 0.53
382_V 590_I 1.044 0.53
123_F 127_N 1.041 0.53
140_T 191_M 1.04 0.53
178_T 541_S 1.04 0.53
454_L 552_I 1.039 0.53
214_E 299_D 1.039 0.53
108_Y 294_F 1.039 0.53
551_L 577_L 1.039 0.53
550_A 578_S 1.037 0.53
212_L 263_L 1.037 0.53
304_V 497_D 1.037 0.53
111_R 280_S 1.034 0.52
199_I 546_F 1.033 0.52
253_L 260_P 1.033 0.52
370_L 577_L 1.032 0.52
451_V 537_T 1.032 0.52
215_S 293_I 1.031 0.52
127_N 590_I 1.031 0.52
326_A 334_G 1.029 0.52
81_W 184_L 1.026 0.51
180_T 573_A 1.024 0.51
151_I 586_L 1.024 0.51
257_A 284_D 1.023 0.51
118_T 121_R 1.023 0.51
142_D 268_V 1.021 0.51
228_E 344_E 1.02 0.51
54_P 57_R 1.02 0.51
447_G 450_G 1.018 0.50
182_A 237_A 1.018 0.50
25_L 330_S 1.016 0.50
202_A 551_L 1.015 0.50
271_A 293_I 1.014 0.50
476_W 530_H 1.014 0.50
558_T 588_A 1.011 0.50
155_K 162_L 1.011 0.50
268_V 292_V 1.011 0.50
175_T 273_M 1.01 0.50
160_V 353_C 1.01 0.50
325_R 335_T 1.01 0.50
176_G 206_G 1.008 0.49
229_Q 335_T 1.006 0.49
80_N 376_R 1.005 0.49
215_S 368_G 1.005 0.49
216_L 233_I 1.005 0.49
50_H 120_A 1.005 0.49
394_E 576_R 1.002 0.49
207_K 361_F 1.002 0.49
123_F 283_I 1.001 0.49
478_E 503_D 1 0.49
153_W 357_K 1 0.49
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1w36D20.99671000.289Contact Map0.498
3e1sA10.83721000.442Contact Map0.564
3upuA30.62011000.697Contact Map0.551
4l0jA10.38491000.766Contact Map0.321
2gk6A20.82731000.786Contact Map0.35
2wjyA10.81581000.787Contact Map0.336
2zpaA20.73361000.812Contact Map0.412
2xzlA10.8241000.817Contact Map0.36
4b3fX10.81411000.825Contact Map0.416
3vkwA10.67271000.828Contact Map0.401
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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