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OPENSEQ.org
SYE - Glutamate--tRNA ligase
UniProt: P04805 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10407
Length: 471 (464)
Sequences: 2058
Seq/Len: 4.44
SYE
Paralog alert: 0.09 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: GLUQ SYE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
87_D 91_E 5.501 1.00
153_D 159_P 4.605 1.00
88_Q 92_E 4.001 1.00
100_C 125_C 3.535 1.00
316_P 348_G 3.437 1.00
392_R 458_N 3.227 1.00
214_L 224_Y 3.145 1.00
157_R 201_E 2.981 1.00
51_P 55_E 2.83 1.00
55_E 59_D 2.814 1.00
160_I 204_I 2.659 1.00
317_E 341_A 2.596 1.00
396_A 458_N 2.567 1.00
148_G 215_K 2.55 1.00
99_Y 132_H 2.53 1.00
84_A 88_Q 2.46 1.00
280_E 284_K 2.444 1.00
151_V 159_P 2.436 1.00
150_V 164_N 2.419 1.00
54_I 74_Y 2.381 1.00
151_V 161_E 2.355 1.00
29_F 33_H 2.337 1.00
81_R 191_D 2.313 1.00
90_L 140_V 2.275 1.00
85_V 191_D 2.265 1.00
190_W 219_A 2.251 1.00
315_P 318_Y 2.235 1.00
111_E 115_K 2.221 1.00
367_D 452_R 2.186 1.00
255_Y 304_L 2.186 1.00
314_L 318_Y 2.184 1.00
274_Q 281_E 2.05 1.00
402_T 405_N 2.043 1.00
86_I 173_R 2.043 1.00
232_G 242_H 2.033 1.00
74_Y 77_K 2.026 1.00
38_V 194_I 2.024 1.00
90_L 97_K 2.002 1.00
211_I 221_V 1.989 1.00
15_L 19_G 1.987 1.00
390_V 417_L 1.974 1.00
258_E 318_Y 1.96 1.00
123_G 126_R 1.95 1.00
394_K 416_E 1.95 1.00
153_D 223_V 1.935 1.00
149_S 161_E 1.916 1.00
403_A 446_H 1.905 1.00
147_E 165_Q 1.901 1.00
7_F 19_G 1.864 1.00
182_N 210_Q 1.861 1.00
392_R 454_I 1.851 1.00
235_G 297_A 1.838 1.00
142_F 212_N 1.822 1.00
142_F 216_A 1.816 1.00
86_I 140_V 1.816 1.00
98_C 125_C 1.813 1.00
62_N 68_W 1.801 1.00
196_H 223_V 1.8 1.00
155_Q 223_V 1.773 1.00
152_F 204_I 1.772 1.00
104_R 124_R 1.751 1.00
99_Y 138_C 1.741 0.99
225_A 288_L 1.738 0.99
149_S 163_S 1.735 0.99
107_A 111_E 1.735 0.99
392_R 396_A 1.731 0.99
101_S 104_R 1.727 0.99
108_L 122_D 1.719 0.99
89_M 94_T 1.666 0.99
97_K 138_C 1.663 0.99
278_T 281_E 1.658 0.99
50_T 53_A 1.655 0.99
265_V 282_M 1.653 0.99
95_A 140_V 1.648 0.99
79_F 178_S 1.644 0.99
352_K 356_E 1.641 0.99
198_I 225_A 1.631 0.99
407_H 442_D 1.623 0.99
97_K 132_H 1.621 0.99
261_L 279_R 1.612 0.99
4_K 194_I 1.572 0.99
420_G 423_K 1.571 0.99
308_H 312_N 1.566 0.99
29_F 196_H 1.565 0.99
144_N 212_N 1.563 0.99
20_A 64_L 1.557 0.99
148_G 164_N 1.544 0.98
452_R 455_E 1.535 0.98
110_E 113_M 1.53 0.98
393_D 396_A 1.523 0.98
413_T 417_L 1.513 0.98
342_D 446_H 1.502 0.98
343_L 447_A 1.5 0.98
104_R 122_D 1.489 0.98
309_H 313_A 1.467 0.98
215_K 221_V 1.463 0.98
389_E 461_L 1.463 0.98
203_H 206_N 1.463 0.98
249_Q 252_D 1.459 0.98
318_Y 322_H 1.454 0.97
454_I 458_N 1.44 0.97
324_Q 328_E 1.436 0.97
390_V 394_K 1.43 0.97
86_I 90_L 1.414 0.97
234_D 242_H 1.409 0.97
343_L 364_F 1.405 0.97
100_C 121_Y 1.399 0.97
90_L 95_A 1.397 0.97
203_H 210_Q 1.391 0.96
5_T 26_S 1.389 0.96
450_K 454_I 1.386 0.96
104_R 108_L 1.384 0.96
142_F 172_I 1.381 0.96
394_K 412_A 1.38 0.96
68_W 71_G 1.377 0.96
301_D 304_L 1.374 0.96
225_A 291_V 1.372 0.96
100_C 124_R 1.364 0.96
104_R 125_C 1.36 0.96
421_M 425_G 1.359 0.96
95_A 172_I 1.356 0.96
112_Q 117_E 1.355 0.96
440_A 443_V 1.35 0.96
4_K 70_E 1.346 0.96
408_H 412_A 1.343 0.95
276_I 306_L 1.343 0.95
81_R 85_V 1.332 0.95
445_V 453_S 1.332 0.95
458_N 462_D 1.331 0.95
279_R 283_I 1.328 0.95
4_K 193_E 1.322 0.95
261_L 282_M 1.32 0.95
99_Y 136_E 1.313 0.95
412_A 415_D 1.299 0.94
51_P 54_I 1.294 0.94
182_N 203_H 1.274 0.94
32_N 287_T 1.271 0.93
347_L 357_M 1.264 0.93
83_N 87_D 1.261 0.93
407_H 411_Q 1.25 0.93
31_R 67_E 1.249 0.93
105_L 121_Y 1.235 0.92
155_Q 288_L 1.228 0.92
401_W 406_V 1.222 0.92
78_R 82_Y 1.221 0.91
86_I 95_A 1.22 0.91
99_Y 137_P 1.219 0.91
400_D 405_N 1.215 0.91
318_Y 321_T 1.215 0.91
63_W 251_R 1.214 0.91
37_F 66_L 1.205 0.91
316_P 345_K 1.188 0.90
31_R 69_D 1.183 0.90
252_D 329_Q 1.181 0.90
314_L 322_H 1.178 0.89
70_E 73_Y 1.166 0.89
62_N 67_E 1.157 0.88
322_H 325_W 1.153 0.88
100_C 104_R 1.149 0.88
398_I 406_V 1.149 0.88
258_E 322_H 1.144 0.88
249_Q 253_D 1.138 0.87
27_W 31_R 1.138 0.87
281_E 285_Y 1.11 0.85
422_G 425_G 1.108 0.85
281_E 284_K 1.106 0.85
32_N 283_I 1.104 0.85
83_N 173_R 1.101 0.85
406_V 445_V 1.096 0.84
79_F 82_Y 1.093 0.84
85_V 217_L 1.087 0.84
437_Q 440_A 1.08 0.83
80_D 83_N 1.078 0.83
362_R 366_E 1.072 0.83
4_K 38_V 1.068 0.82
407_H 440_A 1.068 0.82
383_V 386_Q 1.067 0.82
123_G 143_A 1.065 0.82
22_T 238_L 1.065 0.82
152_F 211_I 1.063 0.82
372_D 375_A 1.062 0.82
107_A 110_E 1.061 0.82
6_R 10_S 1.055 0.81
206_N 210_Q 1.054 0.81
310_Y 313_A 1.049 0.81
157_R 202_D 1.047 0.80
209_R 232_G 1.047 0.80
59_D 251_R 1.046 0.80
9_P 12_T 1.044 0.80
85_V 187_V 1.044 0.80
345_K 348_G 1.042 0.80
211_I 215_K 1.039 0.80
390_V 416_E 1.039 0.80
118_K 166_E 1.039 0.80
91_E 94_T 1.038 0.80
17_V 298_F 1.038 0.80
85_V 219_A 1.036 0.79
304_L 352_K 1.036 0.79
102_K 106_E 1.028 0.79
126_R 143_A 1.027 0.79
152_F 160_I 1.025 0.78
42_E 185_V 1.024 0.78
255_Y 303_L 1.024 0.78
198_I 288_L 1.022 0.78
186_V 213_I 1.021 0.78
81_R 84_A 1.02 0.78
10_S 13_G 1.019 0.78
39_L 58_M 1.018 0.78
288_L 291_V 1.017 0.78
6_R 9_P 1.015 0.77
184_C 190_W 1.015 0.77
274_Q 285_Y 1.015 0.77
320_A 341_A 1.01 0.77
314_L 319_V 1.009 0.77
87_D 90_L 1.006 0.77
125_C 128_S 1.002 0.76
347_L 361_C 1.001 0.76
412_A 416_E 1 0.76
6_R 12_T 1 0.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4griA20.99361000.232Contact Map0.71
2ja2A10.99361000.251Contact Map0.682
1j09A10.95971000.257Contact Map0.72
2cfoA20.99791000.262Contact Map0.734
4g6zA10.97661000.265Contact Map0.708
3al0C10.95541000.291Contact Map0.689
2o5rA10.96391000.297Contact Map0.679
3afhA10.95541000.3Contact Map0.719
1irxA20.91931000.5Contact Map0.402
4h3sA10.90451000.55Contact Map0.479
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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