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OPENSEQ.org
UMUC - Protein UmuC
UniProt: P04152 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11056
Length: 422 (403)
Sequences: 3765
Seq/Len: 9.34
UMUC
Paralog alert: 0.66 [within 20: 0.02] - ratio of genomes with paralogs
Cluster includes: DPO4 UMUC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
90_E 126_T 4.242 1.00
90_E 130_R 3.2 1.00
126_T 130_R 3.196 1.00
18_F 76_L 3.082 1.00
24_G 43_E 2.938 1.00
285_C 347_L 2.834 1.00
182_D 192_S 2.829 1.00
248_I 346_M 2.776 1.00
7_V 135_V 2.703 1.00
259_D 262_S 2.662 1.00
96_E 143_K 2.654 1.00
125_A 129_Q 2.587 1.00
28_V 67_V 2.568 1.00
128_L 161_G 2.547 1.00
196_D 201_K 2.491 1.00
16_T 41_N 2.485 1.00
124_R 161_G 2.46 1.00
73_N 76_L 2.444 1.00
55_W 69_C 2.428 1.00
7_V 133_L 2.352 1.00
122_E 126_T 2.331 1.00
80_M 83_R 2.29 1.00
92_S 105_C 2.281 1.00
264_R 327_T 2.276 1.00
127_V 135_V 2.262 1.00
3_A 107_L 2.235 1.00
91_L 126_T 2.219 1.00
182_D 196_D 2.108 1.00
89_E 95_V 2.101 1.00
200_I 209_T 2.094 1.00
264_R 331_D 2.09 1.00
200_I 206_L 2.036 1.00
201_K 205_D 2.029 1.00
226_V 230_R 1.967 1.00
25_K 68_V 1.954 1.00
278_L 347_L 1.944 1.00
104_F 185_W 1.931 1.00
177_S 207_A 1.916 1.00
57_K 61_L 1.902 1.00
222_L 226_V 1.901 1.00
204_L 208_D 1.896 1.00
289_S 348_G 1.888 1.00
198_M 217_H 1.887 1.00
145_L 166_L 1.878 1.00
18_F 73_N 1.874 1.00
28_V 69_C 1.87 1.00
380_L 389_L 1.834 1.00
139_I 163_V 1.788 1.00
271_A 345_V 1.785 1.00
177_S 204_L 1.766 1.00
85_M 103_A 1.751 1.00
17_V 80_M 1.736 1.00
7_V 84_V 1.735 1.00
19_R 22_L 1.735 1.00
141_Q 172_Q 1.721 1.00
28_V 49_V 1.707 1.00
287_F 349_D 1.703 1.00
224_R 228_E 1.692 1.00
271_A 322_I 1.676 1.00
274_A 347_L 1.669 1.00
215_R 223_E 1.667 1.00
124_R 163_V 1.642 1.00
54_P 57_K 1.634 1.00
249_C 274_A 1.625 1.00
168_N 171_R 1.622 1.00
227_R 232_E 1.615 1.00
3_A 137_V 1.614 1.00
98_Y 104_F 1.612 1.00
293_K 299_L 1.611 1.00
193_K 197_A 1.61 1.00
88_L 105_C 1.589 1.00
359_N 362_D 1.576 1.00
12_A 27_V 1.561 1.00
198_M 218_F 1.539 1.00
12_A 16_T 1.533 1.00
190_R 193_K 1.532 1.00
28_V 37_V 1.528 1.00
121_R 125_A 1.526 1.00
119_F 123_I 1.519 1.00
22_L 27_V 1.515 1.00
157_Q 160_T 1.505 1.00
76_L 80_M 1.504 1.00
318_D 321_D 1.48 1.00
14_C 76_L 1.479 1.00
260_Y 331_D 1.467 1.00
275_A 319_S 1.461 1.00
211_I 223_E 1.458 1.00
87_T 130_R 1.454 1.00
91_L 122_E 1.445 1.00
120_G 137_V 1.44 1.00
140_A 145_L 1.429 0.99
76_L 79_D 1.417 0.99
107_L 119_F 1.396 0.99
9_A 13_S 1.391 0.99
253_F 257_I 1.377 0.99
57_K 60_D 1.368 0.99
211_I 227_R 1.366 0.99
310_V 332_A 1.361 0.99
311_K 349_D 1.361 0.99
43_E 46_A 1.354 0.99
173_R 177_S 1.352 0.99
16_T 43_E 1.351 0.99
278_L 285_C 1.348 0.99
250_S 291_F 1.346 0.99
286_R 349_D 1.344 0.99
47_L 64_R 1.343 0.99
5_C 88_L 1.339 0.99
139_I 165_D 1.337 0.99
4_L 150_N 1.33 0.99
121_R 124_R 1.329 0.99
268_C 323_I 1.327 0.99
30_L 55_W 1.325 0.99
15_E 73_N 1.323 0.99
312_L 316_T 1.322 0.99
274_A 345_V 1.322 0.99
5_C 135_V 1.308 0.99
223_E 227_R 1.307 0.99
14_C 80_M 1.298 0.99
291_F 344_G 1.296 0.99
53_D 61_L 1.291 0.99
38_I 72_S 1.29 0.99
79_D 83_R 1.29 0.99
357_Q 360_L 1.288 0.99
209_T 214_I 1.286 0.99
91_L 123_I 1.285 0.99
30_L 35_G 1.281 0.99
181_V 200_I 1.274 0.99
152_A 164_V 1.273 0.99
279_R 378_D 1.271 0.99
272_A 319_S 1.271 0.99
205_D 208_D 1.27 0.99
209_T 213_F 1.261 0.98
173_R 207_A 1.259 0.98
40_R 51_M 1.253 0.98
74_Y 78_A 1.245 0.98
171_R 174_K 1.244 0.98
194_K 217_H 1.24 0.98
153_A 164_V 1.239 0.98
289_S 309_S 1.236 0.98
275_A 279_R 1.233 0.98
271_A 323_I 1.231 0.98
15_E 77_Y 1.222 0.98
143_K 237_L 1.221 0.98
381_N 388_T 1.218 0.98
214_I 226_V 1.209 0.98
193_K 196_D 1.204 0.98
115_D 118_D 1.2 0.98
192_S 196_D 1.2 0.98
17_V 132_H 1.192 0.97
16_T 23_W 1.188 0.97
29_V 70_F 1.187 0.97
120_G 139_I 1.186 0.97
312_L 325_A 1.183 0.97
210_D 213_F 1.18 0.97
17_V 76_L 1.179 0.97
3_A 120_G 1.175 0.97
292_I 343_A 1.175 0.97
28_V 62_F 1.174 0.97
326_A 345_V 1.172 0.97
37_V 49_V 1.172 0.97
204_L 207_A 1.172 0.97
260_Y 264_R 1.171 0.97
180_P 183_D 1.166 0.97
37_V 40_R 1.165 0.97
16_T 27_V 1.159 0.97
87_T 127_V 1.152 0.97
249_C 277_K 1.149 0.97
257_I 262_S 1.143 0.97
287_F 348_G 1.141 0.97
181_V 195_L 1.14 0.96
5_C 105_C 1.139 0.96
27_V 70_F 1.139 0.96
222_L 225_T 1.134 0.96
94_R 239_E 1.131 0.96
184_V 203_V 1.13 0.96
287_F 311_K 1.12 0.96
310_V 328_R 1.116 0.96
88_L 123_I 1.113 0.96
202_T 205_D 1.11 0.96
86_S 89_E 1.103 0.96
287_F 309_S 1.098 0.95
98_Y 185_W 1.095 0.95
267_I 290_T 1.095 0.95
47_L 62_F 1.094 0.95
213_F 217_H 1.084 0.95
24_G 41_N 1.082 0.95
266_A 269_S 1.075 0.95
148_L 179_L 1.069 0.94
286_R 351_F 1.067 0.94
9_A 16_T 1.067 0.94
49_V 67_V 1.066 0.94
211_I 215_R 1.064 0.94
19_R 70_F 1.064 0.94
10_F 14_C 1.063 0.94
110_V 119_F 1.062 0.94
253_F 266_A 1.059 0.94
39_A 45_K 1.055 0.94
258_T 339_R 1.052 0.94
263_M 330_L 1.05 0.94
319_S 374_M 1.038 0.93
88_L 103_A 1.037 0.93
87_T 126_T 1.035 0.93
87_T 91_L 1.033 0.93
267_I 323_I 1.033 0.93
117_T 165_D 1.03 0.93
257_I 263_M 1.029 0.93
225_T 229_L 1.026 0.93
249_C 273_R 1.021 0.92
255_E 262_S 1.018 0.92
85_M 97_I 1.018 0.92
97_I 100_I 1.016 0.92
87_T 131_T 1.011 0.92
221_V 224_R 1.01 0.92
2_F 237_L 1.009 0.92
200_I 205_D 1.009 0.92
56_F 60_D 1.007 0.92
194_K 197_A 1.006 0.92
207_A 230_R 1.005 0.92
376_V 380_L 1.004 0.92
12_A 39_A 1.004 0.92
293_K 342_K 1.002 0.92
187_I 225_T 1 0.91
185_W 228_E 1 0.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4dezA10.81991000.165Contact Map0.678
1jx4A10.81281000.173Contact Map0.786
4f4yA20.83181000.176Contact Map0.842
3gqcA40.82941000.176Contact Map0.785
4irkB20.79151000.182Contact Map0.775
3pzpA20.80571000.196Contact Map0.775
2aq4A10.81751000.204Contact Map0.728
1t94A20.80331000.205Contact Map0.793
3osnA10.81041000.207Contact Map0.741
3mfiA10.80571000.214Contact Map0.702
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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