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OPENSEQ.org
GUAA - GMP synthase [glutamine-hydrolyzing]
UniProt: P04079 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10420
Length: 525 (516)
Sequences: 1408
Seq/Len: 2.73
GUAA
Paralog alert: 0.02 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
170_N 173_K 5.076 1.00
267_L 426_R 4.793 1.00
53_G 202_C 4.745 1.00
92_M 175_F 4.12 1.00
293_R 321_E 3.985 1.00
322_E 325_K 3.509 1.00
228_D 330_K 3.28 1.00
292_D 296_S 3.2 1.00
389_L 395_Y 3.093 1.00
221_I 225_V 3.01 1.00
219_A 223_E 2.997 1.00
10_I 53_G 2.899 1.00
421_C 425_R 2.881 1.00
291_E 418_K 2.834 1.00
477_T 480_F 2.793 1.00
389_L 399_Y 2.747 1.00
445_S 477_T 2.746 1.00
515_S 520_A 2.737 1.00
231_I 329_V 2.724 1.00
445_S 480_F 2.701 1.00
99_H 149_A 2.588 1.00
259_F 265_L 2.563 1.00
123_R 200_D 2.55 1.00
275_D 279_D 2.54 1.00
313_R 317_E 2.491 1.00
476_E 486_A 2.453 1.00
418_K 422_D 2.422 1.00
247_L 333_A 2.394 1.00
270_A 287_H 2.361 1.00
401_H 447_A 2.352 1.00
245_M 393_L 2.34 1.00
265_L 270_A 2.325 1.00
56_L 82_V 2.319 1.00
399_Y 442_D 2.318 1.00
326_L 329_V 2.295 1.00
228_D 331_W 2.276 1.00
196_R 200_D 2.275 1.00
470_V 507_I 2.263 1.00
492_F 496_V 2.21 1.00
341_V 377_K 2.202 1.00
440_L 492_F 2.193 1.00
259_F 270_A 2.186 1.00
422_D 425_R 2.183 1.00
126_E 189_Q 2.179 1.00
170_N 174_R 2.162 1.00
297_A 314_V 2.154 1.00
271_E 287_H 2.152 1.00
199_R 206_A 2.142 1.00
243_T 333_A 2.123 1.00
101_E 148_T 2.093 1.00
27_V 55_I 2.085 1.00
113_V 158_A 2.044 1.00
74_Y 77_E 2.03 1.00
119_S 157_V 1.972 0.99
431_F 472_L 1.934 0.99
232_L 333_A 1.929 0.99
93_A 151_P 1.928 0.99
297_A 313_R 1.921 0.99
268_N 271_E 1.917 0.99
231_I 258_V 1.915 0.99
429_A 433_E 1.882 0.99
494_G 498_N 1.867 0.99
71_A 91_T 1.865 0.99
488_L 492_F 1.857 0.99
301_E 310_I 1.852 0.99
465_K 508_S 1.848 0.99
243_T 247_L 1.837 0.99
8_H 52_S 1.834 0.99
499_R 503_E 1.829 0.99
217_A 220_R 1.824 0.99
293_R 314_V 1.816 0.99
53_G 204_C 1.8 0.99
469_V 511_V 1.782 0.99
10_I 198_V 1.777 0.99
189_Q 192_R 1.772 0.99
433_E 437_K 1.753 0.98
155_I 171_E 1.74 0.98
10_I 202_C 1.739 0.98
192_R 195_E 1.736 0.98
27_V 198_V 1.726 0.98
117_N 155_I 1.725 0.98
274_L 285_I 1.722 0.98
299_A 415_E 1.721 0.98
438_A 495_R 1.713 0.98
149_A 152_S 1.705 0.98
93_A 168_M 1.704 0.98
8_H 206_A 1.698 0.98
157_V 169_A 1.662 0.98
268_N 272_Q 1.648 0.97
267_L 429_A 1.647 0.97
214_I 387_I 1.637 0.97
460_M 465_K 1.632 0.97
116_V 159_S 1.627 0.97
501_I 515_S 1.624 0.97
437_K 495_R 1.617 0.97
475_V 522_I 1.612 0.97
395_Y 442_D 1.598 0.97
47_R 78_A 1.596 0.97
52_S 204_C 1.595 0.97
168_M 177_G 1.588 0.97
292_D 418_K 1.581 0.96
274_L 287_H 1.578 0.96
444_V 486_A 1.576 0.96
330_K 371_G 1.57 0.96
122_V 167_I 1.566 0.96
389_L 442_D 1.553 0.96
386_K 389_L 1.532 0.96
210_P 387_I 1.524 0.95
426_R 429_A 1.522 0.95
37_W 41_V 1.522 0.95
441_Y 447_A 1.517 0.95
293_R 297_A 1.511 0.95
444_V 488_L 1.509 0.95
485_W 490_Y 1.501 0.95
220_R 224_Q 1.494 0.95
301_E 306_A 1.49 0.95
44_A 48_D 1.48 0.94
455_R 467_D 1.469 0.94
153_D 170_N 1.449 0.93
314_V 317_E 1.438 0.93
256_T 286_V 1.422 0.93
306_A 310_I 1.42 0.93
484_H 516_G 1.42 0.93
487_H 494_G 1.413 0.92
232_L 247_L 1.413 0.92
138_D 188_R 1.409 0.92
71_A 76_F 1.409 0.92
13_L 37_W 1.399 0.92
434_E 437_K 1.399 0.92
432_I 441_Y 1.387 0.91
10_I 204_C 1.385 0.91
420_Y 468_W 1.382 0.91
227_D 254_N 1.381 0.91
474_A 486_A 1.367 0.91
320_D 369_K 1.362 0.90
261_D 287_H 1.35 0.90
303_D 306_A 1.343 0.90
224_Q 373_V 1.335 0.89
449_T 507_I 1.333 0.89
423_L 507_I 1.331 0.89
317_E 320_D 1.323 0.89
245_M 281_F 1.315 0.88
150_I 156_T 1.3 0.87
158_A 167_I 1.297 0.87
195_E 200_D 1.291 0.87
150_I 165_F 1.291 0.87
241_S 393_L 1.287 0.87
452_L 471_S 1.286 0.87
42_T 45_Q 1.283 0.86
401_H 432_I 1.283 0.86
119_S 169_A 1.28 0.86
460_M 501_I 1.277 0.86
494_G 516_G 1.271 0.86
450_V 524_W 1.269 0.86
219_A 222_R 1.267 0.86
41_V 45_Q 1.262 0.85
299_A 418_K 1.259 0.85
431_F 496_V 1.255 0.85
291_E 422_D 1.25 0.84
45_Q 48_D 1.249 0.84
436_R 441_Y 1.24 0.84
214_I 218_V 1.235 0.83
432_I 447_A 1.234 0.83
76_F 92_M 1.232 0.83
320_D 368_M 1.211 0.82
434_E 499_R 1.202 0.81
174_R 203_Q 1.201 0.81
434_E 495_R 1.198 0.81
43_E 74_Y 1.198 0.81
114_E 159_S 1.194 0.81
412_V 421_C 1.193 0.80
258_V 288_V 1.186 0.80
221_I 373_V 1.178 0.79
443_K 476_E 1.177 0.79
70_R 95_Q 1.174 0.79
156_T 165_F 1.171 0.79
323_A 329_V 1.17 0.79
112_Q 138_D 1.167 0.78
11_L 37_W 1.158 0.78
211_A 390_E 1.158 0.78
401_H 441_Y 1.156 0.77
346_A 351_K 1.155 0.77
247_L 373_V 1.151 0.77
160_T 163_C 1.15 0.77
417_K 420_Y 1.146 0.77
73_Q 77_E 1.145 0.77
43_E 72_P 1.14 0.76
217_A 221_I 1.139 0.76
264_L 409_G 1.135 0.76
82_V 175_F 1.129 0.75
221_I 247_L 1.127 0.75
434_E 503_E 1.122 0.74
15_F 56_L 1.122 0.74
440_L 443_K 1.119 0.74
234_L 257_C 1.113 0.74
99_H 148_T 1.107 0.73
120_A 171_E 1.102 0.73
215_D 219_A 1.1 0.72
440_L 444_V 1.093 0.72
295_L 421_C 1.091 0.72
297_A 310_I 1.088 0.71
59_G 63_T 1.082 0.71
422_D 426_R 1.082 0.71
135_P 189_Q 1.075 0.70
229_K 328_D 1.074 0.70
230_V 333_A 1.061 0.68
513_D 525_E 1.056 0.68
472_L 496_V 1.052 0.68
449_T 470_V 1.047 0.67
76_F 95_Q 1.043 0.67
460_M 508_S 1.042 0.66
435_L 444_V 1.039 0.66
511_V 524_W 1.035 0.66
151_P 168_M 1.032 0.65
277_F 285_I 1.031 0.65
184_V 482_T 1.031 0.65
270_A 274_L 1.03 0.65
212_K 390_E 1.03 0.65
40_D 350_G 1.028 0.65
89_M 147_V 1.028 0.65
412_V 425_R 1.026 0.65
467_D 506_G 1.026 0.65
396_D 436_R 1.026 0.65
96_L 175_F 1.024 0.64
56_L 76_F 1.021 0.64
229_K 254_N 1.021 0.64
278_G 285_I 1.019 0.64
77_E 173_K 1.013 0.63
427_A 449_T 1.009 0.63
60_P 69_P 1.004 0.62
367_E 370_M 1.003 0.62
271_E 275_D 1.002 0.62
71_A 95_Q 1 0.62
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3tqiA40.99811000.316Contact Map0.782
1gpmA411000.319Contact Map0.801
3uowA20.9791000.331Contact Map0.699
2ywbA40.95811000.332Contact Map0.803
2vxoA20.9791000.341Contact Map0.582
2dplA20.58671000.609Contact Map0.74
2vpiA20.37711000.808Contact Map0.798
2lxnA10.35621000.837Contact Map0.616
3r75A20.37521000.844Contact Map0.385
2a9vA40.38861000.844Contact Map0.742
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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