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OPENSEQ.org
YGEA - Uncharacterized protein YgeA
UniProt: P03813 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11157
Length: 230 (230)
Sequences: 938
Seq/Len: 4.08
YGEA
Paralog alert: 0.26 [within 20: 0.02] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
56_E 59_K 3.401 1.00
119_R 145_N 3.263 1.00
6_L 82_C 3.24 1.00
72_Q 98_T 2.964 1.00
106_D 137_R 2.94 1.00
130_E 154_R 2.913 1.00
81_L 101_F 2.879 1.00
159_Q 163_E 2.787 1.00
80_V 224_A 2.65 1.00
34_H 44_D 2.473 1.00
115_A 214_F 2.456 1.00
153_E 184_R 2.434 1.00
121_A 185_L 2.367 1.00
20_R 24_E 2.235 1.00
107_A 219_I 2.075 1.00
72_Q 99_L 2.073 1.00
39_L 74_A 2.054 1.00
118_T 191_Q 2.007 1.00
78_G 227_F 1.974 1.00
4_I 78_G 1.968 1.00
72_Q 97_C 1.915 1.00
15_T 40_L 1.858 1.00
147_L 190_A 1.828 1.00
111_A 114_G 1.804 1.00
121_A 193_V 1.784 0.99
156_K 177_Y 1.749 0.99
112_I 214_F 1.726 0.99
90_A 101_F 1.721 0.99
156_K 159_Q 1.718 0.99
127_Y 158_N 1.703 0.99
22_I 225_V 1.68 0.99
132_D 136_G 1.647 0.99
117_M 192_G 1.646 0.99
19_Y 40_L 1.633 0.99
182_I 193_V 1.625 0.99
61_G 65_A 1.609 0.99
109_G 142_F 1.572 0.98
84_N 134_Y 1.563 0.98
111_A 222_E 1.544 0.98
33_L 166_C 1.543 0.98
186_A 211_L 1.531 0.98
110_R 223_D 1.509 0.98
126_R 155_A 1.49 0.98
41_H 67_A 1.461 0.97
25_G 222_E 1.436 0.97
150_E 153_E 1.435 0.97
68_A 97_C 1.413 0.96
81_L 93_I 1.403 0.96
214_F 219_I 1.399 0.96
69_L 72_Q 1.391 0.96
192_G 214_F 1.39 0.96
25_G 225_V 1.386 0.96
158_N 162_F 1.365 0.95
183_A 187_E 1.363 0.95
94_E 101_F 1.346 0.95
108_T 216_T 1.323 0.94
59_K 92_A 1.323 0.94
126_R 158_N 1.319 0.94
12_W 23_N 1.297 0.93
7_L 10_M 1.275 0.93
177_Y 181_V 1.266 0.92
16_I 20_R 1.243 0.91
37_Q 77_E 1.241 0.91
51_C 158_N 1.239 0.91
61_G 92_A 1.222 0.90
10_M 83_T 1.217 0.90
61_G 89_V 1.211 0.90
112_I 120_V 1.207 0.90
91_D 94_E 1.204 0.89
195_F 200_I 1.191 0.89
139_T 145_N 1.182 0.88
4_I 228_M 1.182 0.88
41_H 70_G 1.177 0.88
17_P 217_A 1.173 0.88
160_I 174_S 1.161 0.87
53_R 127_Y 1.156 0.87
29_R 226_A 1.153 0.86
17_P 20_R 1.152 0.86
17_P 201_G 1.132 0.85
182_I 204_V 1.117 0.84
18_Y 22_I 1.106 0.83
69_L 73_R 1.105 0.83
48_I 52_Q 1.095 0.82
83_T 86_M 1.093 0.82
172_E 175_R 1.089 0.82
65_A 96_R 1.086 0.82
120_V 191_Q 1.086 0.82
64_L 89_V 1.085 0.82
22_I 221_A 1.082 0.81
7_L 67_A 1.082 0.81
17_P 21_L 1.08 0.81
221_A 225_V 1.077 0.81
18_Y 220_H 1.074 0.81
84_N 104_I 1.067 0.80
204_V 213_V 1.059 0.79
175_R 208_R 1.055 0.79
11_S 166_C 1.055 0.79
68_A 93_I 1.054 0.79
132_D 135_R 1.052 0.79
110_R 142_F 1.048 0.78
103_H 106_D 1.039 0.78
102_L 105_A 1.037 0.77
150_E 188_Q 1.034 0.77
111_A 219_I 1.027 0.76
52_Q 88_K 1.019 0.76
49_E 162_F 1.007 0.74
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1jflA20.98261000.274Contact Map0.794
3ojcA40.99571000.296Contact Map0.833
2zskA20.97831000.303Contact Map0.822
3s81A40.97391000.316Contact Map0.788
4ix1A80.92611000.489Contact Map0.636
2dgdA40.89131000.518Contact Map0.556
2jfnA10.92171000.526Contact Map0.527
2xedA40.90871000.534Contact Map0.553
3outA30.90871000.538Contact Map0.576
2jfqA20.91741000.541Contact Map0.609
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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