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OPENSEQ.org
UVRD - DNA helicase II
UniProt: P03018 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11064
Length: 720 (716)
Sequences: 4929
Seq/Len: 6.88
UVRD
Paralog alert: 0.87 [within 20: 0.21] - ratio of genomes with paralogs
Cluster includes: REP UVRD
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
559_L 602_G 5.101 1.00
56_S 215_T 4.379 1.00
372_M 554_V 4.252 1.00
333_V 573_V 4.243 1.00
575_M 612_L 4.108 1.00
577_E 631_R 3.526 1.00
11_N 283_Y 3.501 1.00
349_E 568_P 3.456 1.00
336_R 339_T 3.4 1.00
572_I 602_G 3.383 1.00
201_L 231_A 3.362 1.00
568_P 608_Q 3.22 1.00
15_R 19_A 3.217 1.00
16_E 275_E 3.168 1.00
10_L 18_V 3.156 1.00
568_P 607_M 3.116 1.00
336_R 571_F 2.926 1.00
341_Q 347_L 2.91 1.00
230_Y 270_D 2.879 1.00
571_F 611_T 2.737 1.00
352_I 367_L 2.623 1.00
348_A 552_D 2.571 1.00
20_A 25_L 2.562 1.00
204_P 207_L 2.54 1.00
198_E 202_N 2.54 1.00
354_Y 556_L 2.473 1.00
557_M 567_F 2.469 1.00
337_I 350_C 2.432 1.00
569_Q 609_K 2.421 1.00
407_F 411_V 2.404 1.00
287_S 291_S 2.384 1.00
355_R 595_E 2.361 1.00
94_A 196_A 2.353 1.00
336_R 611_T 2.343 1.00
200_W 207_L 2.32 1.00
195_R 198_E 2.307 1.00
43_I 59_A 2.27 1.00
467_A 487_D 2.261 1.00
13_K 16_E 2.227 1.00
88_G 93_L 2.218 1.00
234_R 270_D 2.207 1.00
387_E 508_N 2.181 1.00
569_Q 611_T 2.143 1.00
193_L 228_I 2.143 1.00
53_S 56_S 2.13 1.00
346_A 552_D 2.124 1.00
347_L 373_P 2.066 1.00
262_E 266_R 2.063 1.00
86_W 214_F 2.063 1.00
250_D 303_R 2.037 1.00
329_E 613_T 2.03 1.00
25_L 277_I 2.018 1.00
341_Q 350_C 2.011 1.00
403_D 406_A 2.004 1.00
516_T 534_F 2 1.00
176_A 179_E 1.999 1.00
346_A 349_E 1.995 1.00
481_T 516_T 1.991 1.00
572_I 612_L 1.984 1.00
200_W 235_L 1.981 1.00
559_L 580_F 1.981 1.00
345_G 569_Q 1.956 1.00
207_L 211_R 1.934 1.00
58_M 217_I 1.933 1.00
312_G 608_Q 1.925 1.00
147_N 190_A 1.919 1.00
519_F 533_A 1.915 1.00
37_R 41_H 1.913 1.00
180_A 183_R 1.896 1.00
97_L 200_W 1.894 1.00
596_R 635_E 1.866 1.00
27_V 244_M 1.855 1.00
397_L 410_V 1.853 1.00
179_E 183_R 1.844 1.00
91_H 192_L 1.839 1.00
338_K 370_A 1.832 1.00
363_L 573_V 1.831 1.00
187_V 195_R 1.821 1.00
354_Y 360_S 1.806 1.00
335_N 370_A 1.796 1.00
340_W 569_Q 1.795 1.00
677_R 718_E 1.787 1.00
69_E 73_R 1.783 1.00
181_C 191_E 1.781 1.00
490_L 494_Y 1.772 1.00
674_Q 719_S 1.771 1.00
129_A 176_A 1.768 1.00
122_L 180_A 1.756 1.00
126_L 180_A 1.742 1.00
114_L 186_L 1.726 1.00
25_L 244_M 1.711 1.00
603_V 610_L 1.709 1.00
340_W 571_F 1.696 1.00
41_H 77_L 1.673 1.00
108_P 185_G 1.667 1.00
352_I 363_L 1.666 1.00
334_V 370_A 1.662 1.00
104_D 206_I 1.656 1.00
332_F 613_T 1.654 1.00
231_A 234_R 1.641 1.00
282_N 285_S 1.628 1.00
102_H 187_V 1.627 1.00
491_R 510_E 1.625 1.00
222_F 230_Y 1.625 1.00
387_E 505_R 1.621 1.00
340_W 350_C 1.62 1.00
333_V 571_F 1.62 1.00
345_G 608_Q 1.617 1.00
31_A 294_N 1.616 1.00
47_M 78_M 1.616 1.00
292_A 318_I 1.609 1.00
217_I 237_A 1.6 1.00
290_L 308_L 1.583 1.00
101_H 209_H 1.581 1.00
210_Y 214_F 1.575 1.00
359_Q 574_G 1.575 1.00
323_A 332_F 1.563 1.00
97_L 196_A 1.554 0.99
491_R 506_I 1.554 0.99
566_E 607_M 1.545 0.99
299_N 635_E 1.538 0.99
320_L 614_Y 1.538 0.99
153_G 228_I 1.536 0.99
201_L 235_L 1.534 0.99
338_K 342_D 1.53 0.99
197_H 232_W 1.529 0.99
629_P 633_I 1.527 0.99
105_A 199_L 1.526 0.99
101_H 210_Y 1.522 0.99
281_Q 309_W 1.521 0.99
367_L 556_L 1.518 0.99
296_L 603_V 1.507 0.99
180_A 184_A 1.507 0.99
333_V 363_L 1.506 0.99
102_H 105_A 1.491 0.99
331_R 370_A 1.489 0.99
129_A 180_A 1.482 0.99
489_G 492_T 1.48 0.99
492_T 495_E 1.479 0.99
347_L 350_C 1.477 0.99
676_V 717_L 1.475 0.99
426_V 437_L 1.475 0.99
267_F 274_A 1.468 0.99
366_A 370_A 1.465 0.99
219_V 233_I 1.458 0.99
107_L 187_V 1.457 0.99
227_N 260_Q 1.456 0.99
675_R 683_E 1.452 0.99
45_W 49_V 1.451 0.99
19_A 45_W 1.451 0.99
334_V 366_A 1.443 0.99
46_L 216_N 1.441 0.99
297_I 300_N 1.428 0.99
13_K 281_Q 1.428 0.99
331_R 366_A 1.428 0.99
408_E 427_R 1.427 0.99
354_Y 573_V 1.422 0.99
322_C 614_Y 1.421 0.99
281_Q 311_D 1.421 0.99
23_S 242_K 1.419 0.99
599_A 603_V 1.415 0.99
575_M 599_A 1.411 0.99
177_Y 188_D 1.408 0.99
46_L 52_C 1.405 0.99
16_E 19_A 1.403 0.99
160_Q 175_Q 1.396 0.99
44_A 77_L 1.388 0.99
97_L 210_Y 1.387 0.99
483_R 487_D 1.381 0.99
123_L 143_M 1.375 0.98
178_Q 181_C 1.375 0.98
559_L 572_I 1.373 0.98
266_R 270_D 1.37 0.98
187_V 192_L 1.369 0.98
197_H 231_A 1.368 0.98
412_N 416_R 1.364 0.98
216_N 242_K 1.363 0.98
175_Q 179_E 1.356 0.98
43_I 74_I 1.342 0.98
482_D 513_V 1.34 0.98
699_Q 709_W 1.339 0.98
397_L 407_F 1.337 0.98
292_A 603_V 1.332 0.98
391_A 509_L 1.331 0.98
366_A 369_Q 1.328 0.98
698_L 712_A 1.325 0.98
72_H 76_Q 1.321 0.98
93_L 97_L 1.321 0.98
345_G 350_C 1.315 0.98
295_A 637_P 1.314 0.98
126_L 176_A 1.313 0.98
340_W 611_T 1.309 0.98
569_Q 608_Q 1.304 0.98
391_A 512_L 1.302 0.98
395_L 481_T 1.301 0.98
204_P 208_Q 1.294 0.98
241_G 273_G 1.293 0.97
17_A 27_V 1.293 0.97
43_I 57_I 1.289 0.97
151_D 190_A 1.288 0.97
126_L 130_M 1.284 0.97
329_E 574_G 1.28 0.97
58_M 214_F 1.274 0.97
147_N 151_D 1.273 0.97
323_A 613_T 1.273 0.97
336_R 340_W 1.269 0.97
155_R 158_H 1.265 0.97
100_A 213_R 1.264 0.97
176_A 180_A 1.262 0.97
391_A 481_T 1.26 0.97
471_E 483_R 1.257 0.97
74_I 87_V 1.256 0.97
225_T 263_N 1.253 0.97
249_D 306_K 1.253 0.97
146_I 150_K 1.25 0.97
42_R 244_M 1.248 0.97
61_T 66_A 1.244 0.97
287_S 313_A 1.244 0.97
125_R 180_A 1.244 0.97
701_A 707_I 1.241 0.97
334_V 554_V 1.238 0.97
394_Y 484_V 1.231 0.96
268_L 304_L 1.229 0.96
293_A 603_V 1.218 0.96
677_R 683_E 1.217 0.96
442_R 466_D 1.214 0.96
221_E 563_K 1.213 0.96
350_C 571_F 1.206 0.96
107_L 195_R 1.202 0.96
289_I 293_A 1.201 0.96
12_D 15_R 1.198 0.96
93_L 210_Y 1.195 0.95
675_R 685_T 1.192 0.95
208_Q 212_E 1.189 0.95
337_I 347_L 1.185 0.95
364_E 374_Y 1.179 0.95
296_L 599_A 1.175 0.95
266_R 269_N 1.172 0.95
388_I 512_L 1.172 0.95
199_L 206_I 1.171 0.95
97_L 199_L 1.168 0.95
123_L 146_I 1.166 0.95
475_M 479_V 1.164 0.95
252_S 255_G 1.163 0.95
340_W 345_G 1.162 0.95
393_S 409_R 1.161 0.94
303_R 306_K 1.161 0.94
196_A 232_W 1.159 0.94
112_Q 118_D 1.158 0.94
7_L 15_R 1.155 0.94
340_W 609_K 1.155 0.94
390_D 409_R 1.154 0.94
324_F 328_D 1.153 0.94
319_S 336_R 1.153 0.94
424_D 428_Q 1.152 0.94
218_L 244_M 1.152 0.94
337_I 554_V 1.149 0.94
357_N 360_S 1.149 0.94
208_Q 211_R 1.146 0.94
396_R 403_D 1.138 0.94
150_K 191_E 1.138 0.94
20_A 23_S 1.138 0.94
519_F 534_F 1.134 0.94
675_R 703_Q 1.132 0.93
123_L 173_V 1.128 0.93
130_M 176_A 1.127 0.93
98_L 196_A 1.126 0.93
268_L 276_T 1.124 0.93
612_L 633_I 1.124 0.93
688_N 699_Q 1.121 0.93
601_V 604_T 1.116 0.93
351_A 567_F 1.115 0.93
203_K 206_I 1.115 0.93
601_V 605_R 1.111 0.93
20_A 275_E 1.106 0.92
511_E 514_T 1.099 0.92
687_V 707_I 1.098 0.92
600_Y 604_T 1.097 0.92
91_H 193_L 1.093 0.92
68_A 71_R 1.093 0.92
339_T 343_N 1.091 0.92
101_H 104_D 1.089 0.92
12_D 16_E 1.086 0.91
350_C 569_Q 1.079 0.91
197_H 201_L 1.076 0.91
337_I 571_F 1.076 0.91
407_F 441_C 1.073 0.91
319_S 609_K 1.073 0.91
636_L 640_C 1.069 0.91
149_Q 159_I 1.069 0.91
288_N 318_I 1.066 0.90
689_M 698_L 1.064 0.90
42_R 242_K 1.058 0.90
419_G 422_T 1.058 0.90
250_D 297_I 1.056 0.90
156_P 174_Y 1.056 0.90
86_W 96_R 1.055 0.90
421_R 425_V 1.054 0.90
512_L 516_T 1.053 0.90
28_L 249_D 1.053 0.90
396_R 539_A 1.049 0.90
96_R 100_A 1.048 0.89
104_D 205_H 1.048 0.89
685_T 701_A 1.04 0.89
694_E 713_A 1.04 0.89
154_L 159_I 1.037 0.89
478_H 520_S 1.036 0.89
40_V 74_I 1.036 0.89
31_A 600_Y 1.036 0.89
557_M 562_A 1.033 0.89
690_E 697_R 1.033 0.89
22_R 216_N 1.032 0.88
65_K 69_E 1.031 0.88
8_D 15_R 1.031 0.88
60_V 93_L 1.03 0.88
197_H 235_L 1.023 0.88
116_S 119_Q 1.022 0.88
193_L 232_W 1.022 0.88
252_S 259_A 1.021 0.88
211_R 239_D 1.02 0.88
453_R 457_A 1.02 0.88
398_I 468_L 1.02 0.88
178_Q 182_D 1.018 0.88
476_P 479_V 1.018 0.88
697_R 709_W 1.017 0.87
91_H 560_H 1.013 0.87
5_Y 8_D 1.013 0.87
21_P 216_N 1.012 0.87
572_I 575_M 1.01 0.87
261_V 264_I 1.009 0.87
710_L 715_A 1.008 0.87
127_I 132_L 1.008 0.87
300_N 635_E 1.003 0.87
32_G 35_K 1.003 0.87
47_M 52_C 1.003 0.87
401_R 469_A 1.003 0.87
104_D 203_K 1.003 0.87
396_R 406_A 1.002 0.86
341_Q 346_A 1.002 0.86
222_F 264_I 1.001 0.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4c2tA40.99311000.057Contact Map0.844
1pjrA10.99171000.062Contact Map0.849
1uaaA20.9251000.222Contact Map0.799
3lfuA10.89861000.229Contact Map0.782
4c2uA20.90141000.244Contact Map0.825
3u4qA10.95831000.28Contact Map0.752
1w36B20.91671000.341Contact Map0.746
3u4qB10.91111000.408Contact Map0.673
4b3fX10.59441000.664Contact Map0.527
2wjyA10.59031000.69Contact Map0.604
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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