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OPENSEQ.org

PINE - DNA-invertase from lambdoid prophage e14
UniProt: P03014 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10737
Length: 184 (181)
Sequences: 4154
Seq/Len: 22.95

PINE
Paralog alert: 0.63 [within 20: 0.19] - ratio of genomes with paralogs
Cluster includes: PINE PINQ PINR
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
44_G 47_K 3.934 1.00
31_F 51_T 3.48 1.00
48_L 58_L 2.902 1.00
33_D 44_G 2.679 1.00
154_L 167_I 2.658 1.00
6_V 19_R 2.412 1.00
115_E 122_R 2.408 1.00
19_R 23_N 2.233 1.00
80_L 85_I 2.2 1.00
89_S 92_D 2.14 1.00
103_F 114_M 2.132 1.00
129_T 133_Q 2.07 1.00
162_Q 166_I 2.054 1.00
102_R 117_E 2.031 1.00
150_Q 154_L 1.986 1.00
4_G 22_L 1.97 1.00
70_M 106_H 1.957 1.00
19_R 30_I 1.911 1.00
113_E 117_E 1.893 1.00
106_H 110_A 1.821 1.00
102_R 113_E 1.807 1.00
10_T 13_Q 1.778 1.00
154_L 159_T 1.754 1.00
123_T 127_L 1.753 1.00
71_R 75_V 1.749 1.00
159_T 167_I 1.727 1.00
19_R 32_E 1.718 1.00
103_F 110_A 1.692 1.00
120_V 124_K 1.687 1.00
20_N 24_C 1.678 1.00
70_M 109_G 1.674 1.00
79_E 83_R 1.672 1.00
3_I 48_L 1.626 1.00
52_L 58_L 1.61 1.00
45_L 76_L 1.592 1.00
38_T 116_R 1.59 1.00
130_A 135_R 1.562 1.00
81_R 102_R 1.512 1.00
73_L 109_G 1.468 1.00
70_M 74_V 1.464 1.00
52_L 85_I 1.457 1.00
29_L 47_K 1.427 1.00
165_A 175_L 1.422 1.00
116_R 119_I 1.411 1.00
74_V 106_H 1.396 0.99
3_I 51_T 1.368 0.99
172_V 176_Y 1.307 0.99
128_E 132_A 1.303 0.99
8_V 13_Q 1.297 0.99
155_I 164_V 1.29 0.99
77_V 105_F 1.279 0.99
78_E 82_E 1.277 0.99
71_R 78_E 1.276 0.99
64_D 112_A 1.256 0.99
159_T 163_K 1.24 0.98
98_T 101_G 1.229 0.98
67_G 73_L 1.222 0.98
23_N 30_I 1.209 0.98
162_Q 172_V 1.207 0.98
60_V 87_F 1.203 0.98
4_G 30_I 1.2 0.98
160_P 163_K 1.197 0.98
126_G 130_A 1.196 0.98
35_I 43_P 1.192 0.98
153_R 157_A 1.177 0.98
41_E 46_K 1.176 0.98
2_L 88_R 1.166 0.97
127_L 137_G 1.157 0.97
144_T 147_Q 1.152 0.97
6_V 15_T 1.148 0.97
31_F 48_L 1.145 0.97
61_W 125_A 1.129 0.97
124_K 127_L 1.116 0.96
154_L 164_V 1.088 0.96
57_T 88_R 1.085 0.96
45_L 48_L 1.075 0.95
151_A 175_L 1.066 0.95
155_I 179_F 1.061 0.95
151_A 164_V 1.056 0.95
60_V 89_S 1.054 0.95
62_K 91_T 1.047 0.94
129_T 132_A 1.047 0.94
154_L 157_A 1.046 0.94
103_F 111_L 1.045 0.94
22_L 59_V 1.031 0.94
148_W 151_A 1.028 0.94
2_L 27_C 1.027 0.94
175_L 178_R 1.025 0.93
107_V 110_A 1.023 0.93
45_L 66_L 1.016 0.93
127_L 131_R 1.016 0.93
64_D 122_R 1.007 0.93
118_L 122_R 1.006 0.93
35_I 39_K 1.004 0.93
47_K 51_T 1.004 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3uj3X111000.073Contact Map0.408
2r0qC411000.102Contact Map0.65
1gdtA20.97831000.121Contact Map0.647
4bqqA20.98371000.271Contact Map0.678
3g13A20.80431000.334Contact Map0.562
2gm5A40.74461000.341Contact Map0.847
3guvA10.7881000.351Contact Map0.525
3pkzA120.6251000.414Contact Map0.777
3lhkA40.76631000.425Contact Map0.618
3ilxA20.695799.90.439Contact Map0.617

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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