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OPENSEQ.org
MANA - Mannose-6-phosphate isomerase
UniProt: P00946 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10566
Length: 391 (390)
Sequences: 1107
Seq/Len: 2.84
MANA
Paralog alert: 0.20 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
11_Y 34_A 3.006 1.00
48_V 61_V 2.904 1.00
3_K 365_E 2.885 1.00
141_P 242_N 2.496 1.00
136_V 262_A 2.432 1.00
241_L 261_V 2.343 1.00
56_V 64_S 2.282 1.00
361_L 367_A 2.163 1.00
273_L 290_N 2.158 1.00
254_P 291_V 2.149 1.00
347_E 383_R 2.09 1.00
140_T 243_P 2.011 1.00
344_F 366_S 1.986 1.00
104_N 290_N 1.954 0.99
248_F 318_V 1.923 0.99
72_E 76_K 1.919 0.99
257_Y 262_A 1.917 0.99
103_H 107_I 1.899 0.99
65_D 68_T 1.878 0.99
102_K 106_E 1.878 0.99
95_S 274_R 1.861 0.99
341_A 386_R 1.817 0.99
102_K 130_N 1.815 0.99
62_I 70_L 1.785 0.99
378_V 384_L 1.759 0.99
38_M 366_S 1.758 0.99
265_V 387_V 1.713 0.98
129_P 271_N 1.706 0.98
113_N 119_M 1.66 0.98
56_V 60_D 1.654 0.98
98_V 291_V 1.653 0.98
57_S 60_D 1.651 0.98
184_F 232_S 1.633 0.97
359_L 367_A 1.604 0.97
20_T 23_Y 1.595 0.97
38_M 342_I 1.583 0.97
17_T 21_E 1.577 0.97
362_K 365_E 1.57 0.97
85_F 265_V 1.549 0.96
93_P 223_F 1.545 0.96
9_Q 44_S 1.543 0.96
5_I 49_Q 1.538 0.96
20_T 33_M 1.538 0.96
204_S 208_S 1.535 0.96
12_A 279_P 1.534 0.96
16_K 21_E 1.532 0.96
143_L 240_K 1.531 0.96
41_H 44_S 1.505 0.95
27_N 33_M 1.502 0.95
349_D 362_K 1.497 0.95
98_V 290_N 1.487 0.95
270_D 342_I 1.46 0.94
276_G 279_P 1.429 0.93
184_F 188_L 1.414 0.93
36_L 87_V 1.402 0.92
113_N 129_P 1.4 0.92
61_V 69_L 1.394 0.92
236_L 249_L 1.39 0.92
327_D 383_R 1.382 0.92
163_G 205_A 1.367 0.91
131_H 267_A 1.365 0.91
107_I 111_K 1.355 0.91
6_N 366_S 1.345 0.90
29_S 33_M 1.338 0.90
36_L 366_S 1.335 0.90
141_P 243_P 1.33 0.90
87_V 263_L 1.31 0.89
7_S 44_S 1.297 0.88
98_V 273_L 1.294 0.88
216_T 220_I 1.288 0.87
350_A 382_G 1.285 0.87
220_I 223_F 1.278 0.87
145_M 258_L 1.265 0.86
25_M 344_F 1.264 0.86
12_A 92_Q 1.262 0.86
263_L 385_A 1.259 0.86
19_L 23_Y 1.258 0.86
112_E 124_R 1.242 0.85
4_L 21_E 1.236 0.84
325_L 383_R 1.234 0.84
77_R 319_D 1.231 0.84
331_K 379_K 1.229 0.84
25_M 366_S 1.229 0.84
46_S 139_L 1.228 0.84
66_K 71_G 1.223 0.84
17_T 20_T 1.219 0.83
25_M 33_M 1.219 0.83
131_H 266_M 1.216 0.83
45_S 59_R 1.214 0.83
165_H 238_V 1.213 0.83
334_T 375_P 1.212 0.83
245_E 302_L 1.212 0.83
15_S 261_V 1.207 0.82
9_Q 43_K 1.206 0.82
43_K 270_D 1.203 0.82
343_L 384_L 1.2 0.82
141_P 240_K 1.2 0.82
15_S 89_C 1.193 0.81
104_N 108_G 1.193 0.81
273_L 286_E 1.19 0.81
19_L 22_L 1.187 0.81
286_E 289_A 1.186 0.81
53_G 61_V 1.185 0.81
265_V 323_F 1.185 0.81
275_A 279_P 1.181 0.81
197_R 200_A 1.177 0.80
195_K 228_S 1.177 0.80
345_C 348_G 1.177 0.80
275_A 278_T 1.172 0.80
101_N 104_N 1.167 0.79
203_K 207_D 1.163 0.79
351_T 360_Q 1.162 0.79
117_I 123_E 1.159 0.79
6_N 38_M 1.155 0.78
85_F 387_V 1.147 0.78
143_L 219_L 1.147 0.78
251_A 267_A 1.144 0.78
143_L 238_V 1.142 0.77
72_E 193_E 1.139 0.77
111_K 115_A 1.126 0.76
344_F 387_V 1.124 0.76
149_R 157_L 1.122 0.76
137_F 323_F 1.121 0.75
242_N 245_E 1.121 0.75
124_R 127_K 1.115 0.75
271_N 276_G 1.113 0.75
130_N 317_P 1.107 0.74
39_G 88_L 1.103 0.74
181_S 185_A 1.103 0.74
351_T 379_K 1.101 0.74
103_H 106_E 1.099 0.73
59_R 63_E 1.099 0.73
352_L 358_Q 1.095 0.73
241_L 247_M 1.093 0.73
178_E 181_S 1.092 0.73
93_P 345_C 1.09 0.73
102_K 131_H 1.089 0.72
266_M 283_D 1.089 0.72
220_I 224_Y 1.085 0.72
6_N 46_S 1.08 0.72
57_S 346_V 1.079 0.71
125_N 273_L 1.078 0.71
6_N 137_F 1.077 0.71
347_E 363_P 1.075 0.71
91_A 259_Q 1.075 0.71
133_P 267_A 1.071 0.71
126_Y 286_E 1.069 0.70
378_V 382_G 1.068 0.70
353_W 358_Q 1.063 0.70
18_A 21_E 1.051 0.69
241_L 257_Y 1.049 0.68
41_H 268_N 1.047 0.68
351_T 358_Q 1.044 0.68
85_F 323_F 1.044 0.68
38_M 83_F 1.043 0.68
40_A 58_L 1.041 0.68
274_R 280_K 1.041 0.68
16_K 30_S 1.04 0.67
126_Y 229_G 1.037 0.67
6_N 36_L 1.036 0.67
345_C 384_L 1.034 0.67
357_Q 379_K 1.029 0.66
352_L 369_I 1.029 0.66
194_E 197_R 1.023 0.66
183_L 233_P 1.023 0.66
38_M 85_F 1.022 0.65
188_L 232_S 1.021 0.65
266_M 272_V 1.02 0.65
67_S 72_E 1.015 0.65
186_S 190_M 1.013 0.64
184_F 198_A 1.01 0.64
328_L 384_L 1.006 0.64
138_A 257_Y 1.005 0.64
236_L 243_P 1.005 0.64
178_E 182_E 1.004 0.63
304_Q 358_Q 1.004 0.63
286_E 290_N 1.003 0.63
19_L 256_A 1.003 0.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2wfpA111000.076Contact Map0.625
1pmiA10.96681000.139Contact Map0.621
1zx5A10.73911000.377Contact Map0.585
1qwrA20.75961000.414Contact Map0.66
3rnsA10.562799.20.888Contact Map0.597
3myxA20.55598.10.924Contact Map0.55
3h7jA20.5192980.926Contact Map0.613
3bu7A20.7289980.927Contact Map0.516
4e2qA160.631797.60.932Contact Map0.46
3es4A20.276297.50.934Contact Map0.762
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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