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OPENSEQ.org
SDHD - D-serine dehydratase
UniProt: P00926 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10249
Length: 442 (391)
Sequences: 1387
Seq/Len: 3.55
SDHD
Paralog alert: 0.38 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: CYSK CYSM DPAL SDHD TDCB TRPB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
300_H 359_G 4.589 1.00
255_L 420_L 4.271 1.00
274_V 287_V 4.044 1.00
192_A 213_E 3.501 1.00
367_T 396_R 3.461 1.00
53_H 246_L 3.434 1.00
81_L 420_L 3.171 1.00
83_A 102_Q 3.051 1.00
83_A 92_E 3.002 1.00
79_S 111_L 2.694 1.00
105_L 375_L 2.621 1.00
269_D 418_T 2.598 1.00
257_A 261_Q 2.556 1.00
249_S 253_Q 2.502 1.00
102_Q 267_D 2.498 1.00
274_V 301_C 2.432 1.00
108_D 424_T 2.343 1.00
94_E 374_W 2.285 1.00
302_F 359_G 2.252 1.00
187_T 208_T 2.244 1.00
185_K 208_T 2.243 1.00
189_H 226_A 2.196 1.00
267_D 418_T 2.188 1.00
273_F 302_F 2.177 1.00
287_V 301_C 2.171 1.00
187_T 210_V 2.11 1.00
255_L 287_V 2.106 1.00
413_Q 417_T 2.053 1.00
196_A 200_A 2.038 1.00
259_F 420_L 2.001 1.00
70_T 75_G 1.999 1.00
312_M 353_M 1.987 1.00
179_S 186_V 1.956 1.00
349_V 360_F 1.944 1.00
414_L 417_T 1.943 1.00
85_P 93_K 1.909 1.00
95_Y 399_A 1.905 1.00
393_G 397_V 1.875 1.00
75_G 111_L 1.851 0.99
222_E 225_K 1.826 0.99
56_L 136_E 1.818 0.99
52_A 55_R 1.808 0.99
292_K 358_D 1.807 0.99
114_S 177_I 1.803 0.99
366_Q 370_D 1.794 0.99
203_R 208_T 1.792 0.99
83_A 104_L 1.771 0.99
363_L 396_R 1.748 0.99
104_L 267_D 1.742 0.99
262_Q 267_D 1.729 0.99
95_Y 395_Q 1.723 0.99
161_Y 226_A 1.714 0.99
68_P 73_T 1.705 0.99
361_Y 393_G 1.642 0.98
75_G 79_S 1.632 0.98
60_A 64_A 1.615 0.98
397_V 400_S 1.614 0.98
72_A 262_Q 1.601 0.98
273_F 419_H 1.601 0.98
259_F 267_D 1.588 0.98
234_F 239_E 1.584 0.98
69_E 123_I 1.576 0.98
87_M 374_W 1.558 0.98
45_T 230_D 1.548 0.98
68_P 72_A 1.536 0.97
226_A 229_S 1.504 0.97
259_F 418_T 1.493 0.97
371_M 392_A 1.482 0.97
275_Y 302_F 1.48 0.97
65_K 135_L 1.474 0.96
256_K 296_G 1.47 0.96
197_W 430_P 1.466 0.96
375_L 391_M 1.463 0.96
69_E 181_R 1.459 0.96
293_L 297_D 1.455 0.96
194_A 203_R 1.452 0.96
87_M 391_M 1.449 0.96
67_F 253_Q 1.447 0.96
287_V 422_W 1.439 0.96
315_G 326_V 1.433 0.96
94_E 378_E 1.418 0.95
375_L 423_A 1.416 0.95
387_A 424_T 1.414 0.95
194_A 211_E 1.414 0.95
50_Q 54_A 1.411 0.95
122_G 178_M 1.395 0.95
245_F 310_P 1.381 0.94
316_V 354_E 1.376 0.94
252_G 287_V 1.372 0.94
66_A 70_T 1.363 0.94
86_A 93_K 1.36 0.94
54_A 243_T 1.354 0.94
273_F 300_H 1.349 0.93
220_V 333_N 1.347 0.93
160_Q 232_N 1.34 0.93
87_M 103_L 1.332 0.93
101_G 394_P 1.331 0.93
430_P 434_M 1.315 0.92
302_F 397_V 1.314 0.92
245_F 309_S 1.31 0.92
61_P 64_A 1.31 0.92
193_D 197_W 1.3 0.92
260_A 270_N 1.296 0.91
374_W 395_Q 1.289 0.91
162_S 179_S 1.283 0.91
73_T 262_Q 1.281 0.91
177_I 205_H 1.278 0.91
273_F 397_V 1.27 0.90
54_A 57_S 1.264 0.90
393_G 396_R 1.263 0.90
394_P 421_V 1.259 0.90
252_G 290_G 1.258 0.90
63_L 67_F 1.25 0.89
369_Y 385_P 1.245 0.89
108_D 387_A 1.243 0.89
302_F 393_G 1.233 0.89
56_L 59_F 1.228 0.88
81_L 259_F 1.223 0.88
81_L 262_Q 1.219 0.88
303_F 349_V 1.214 0.88
175_I 179_S 1.214 0.88
53_H 247_G 1.212 0.87
51_D 55_R 1.196 0.86
246_L 290_G 1.193 0.86
68_P 85_P 1.19 0.86
200_A 430_P 1.177 0.85
192_A 195_R 1.177 0.85
84_I 87_M 1.172 0.85
126_V 162_S 1.163 0.84
66_A 250_V 1.155 0.84
114_S 119_A 1.154 0.84
63_L 66_A 1.152 0.84
387_A 421_V 1.146 0.83
303_F 360_F 1.146 0.83
311_C 344_R 1.137 0.82
273_F 413_Q 1.135 0.82
59_F 136_E 1.133 0.82
270_N 299_V 1.133 0.82
304_A 363_L 1.133 0.82
179_S 236_I 1.129 0.82
56_L 61_P 1.127 0.82
178_M 236_I 1.123 0.81
245_F 312_M 1.122 0.81
71_A 261_Q 1.121 0.81
87_M 92_E 1.121 0.81
307_T 362_T 1.12 0.81
160_Q 185_K 1.118 0.81
394_P 419_H 1.117 0.81
312_M 315_G 1.109 0.80
75_G 116_S 1.104 0.80
73_T 322_D 1.101 0.80
364_S 367_T 1.093 0.79
68_P 262_Q 1.092 0.79
48_D 51_D 1.083 0.78
221_E 225_K 1.078 0.78
376_A 382_R 1.076 0.77
245_F 315_G 1.076 0.77
195_R 435_N 1.076 0.77
431_E 434_M 1.07 0.77
273_F 414_L 1.068 0.77
275_Y 394_P 1.066 0.76
75_G 123_I 1.063 0.76
400_S 413_Q 1.061 0.76
54_A 58_R 1.058 0.76
237_D 243_T 1.054 0.75
274_V 291_L 1.053 0.75
102_Q 416_N 1.053 0.75
78_E 257_A 1.053 0.75
314_L 353_M 1.052 0.75
304_A 362_T 1.048 0.75
161_Y 233_C 1.048 0.75
310_P 315_G 1.046 0.74
227_A 233_C 1.043 0.74
361_Y 396_R 1.038 0.74
270_N 291_L 1.024 0.72
86_A 378_E 1.023 0.72
229_S 232_N 1.02 0.72
126_V 236_I 1.019 0.72
197_W 431_E 1.014 0.71
421_V 424_T 1.012 0.71
256_K 270_N 1.011 0.71
130_A 162_S 1.011 0.71
328_D 331_I 1.003 0.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3ss7X111000.336Contact Map0.409
4d9iA20.84841000.53Contact Map0.556
4negA20.83941000.56Contact Map0.742
1x1qA20.87561000.561Contact Map0.745
2o2eA20.86881000.562Contact Map0.706
1v71A10.73081000.576Contact Map0.551
2gn0A40.76921000.58Contact Map0.614
1ve5A40.70361000.581Contact Map0.59
1tdjA10.75341000.582Contact Map0.526
1qopB10.82581000.586Contact Map0.612
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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