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OPENSEQ.org
DCDA - Diaminopimelate decarboxylase
UniProt: P00861 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10549
Length: 420 (396)
Sequences: 3507
Seq/Len: 8.86
DCDA
Paralog alert: 0.47 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
230_V 275_A 4.631 1.00
20_L 28_V 3.659 1.00
109_L 130_L 3.4 1.00
138_R 184_Q 3.357 1.00
128_D 176_D 3.302 1.00
89_N 95_D 3.159 1.00
41_A 68_Q 3.115 1.00
81_E 111_R 2.861 1.00
37_R 68_Q 2.859 1.00
282_T 298_V 2.711 1.00
24_F 402_A 2.693 1.00
184_Q 220_Q 2.68 1.00
110_E 136_G 2.66 1.00
106_Q 132_Q 2.603 1.00
48_V 264_K 2.569 1.00
21_P 26_C 2.497 1.00
110_E 133_V 2.487 1.00
298_V 337_V 2.46 1.00
43_L 272_F 2.45 1.00
111_R 115_L 2.409 1.00
37_R 67_E 2.37 1.00
280_L 300_A 2.34 1.00
33_A 398_D 2.316 1.00
296_V 364_V 2.314 1.00
40_I 70_V 2.259 1.00
413_E 416_A 2.184 1.00
84_L 115_L 2.161 1.00
109_L 119_V 2.15 1.00
289_Q 294_H 2.123 1.00
318_S 373_H 2.097 1.00
391_L 409_Q 2.066 1.00
110_E 114_E 2.023 1.00
55_A 274_V 2.02 1.00
72_V 83_A 2.016 1.00
106_Q 129_Q 1.954 1.00
282_T 370_L 1.939 1.00
131_G 180_R 1.922 1.00
296_V 335_T 1.914 1.00
124_V 173_A 1.912 1.00
281_I 369_Y 1.892 1.00
177_V 185_L 1.858 1.00
72_V 88_Y 1.853 1.00
19_R 22_A 1.839 1.00
35_I 39_Q 1.838 1.00
65_M 273_L 1.833 1.00
131_G 182_H 1.83 1.00
11_D 18_L 1.827 1.00
74_S 80_I 1.798 1.00
28_V 393_P 1.782 1.00
287_V 296_V 1.767 1.00
84_L 90_P 1.766 1.00
66_R 88_Y 1.761 1.00
395_V 404_L 1.758 1.00
28_V 281_I 1.757 1.00
34_Q 38_R 1.748 1.00
51_F 55_A 1.735 1.00
283_Q 369_Y 1.713 1.00
113_S 133_V 1.708 1.00
37_R 41_A 1.705 1.00
175_L 215_F 1.696 1.00
407_R 417_L 1.691 1.00
42_A 242_E 1.672 1.00
17_L 30_V 1.655 1.00
36_I 274_V 1.634 1.00
124_V 170_D 1.622 1.00
40_I 65_M 1.612 1.00
135_P 182_H 1.579 1.00
39_Q 276_Q 1.573 1.00
104_I 126_M 1.566 1.00
176_D 179_Q 1.56 1.00
202_E 257_R 1.559 1.00
81_E 85_A 1.553 1.00
206_G 258_H 1.548 1.00
131_G 135_P 1.547 1.00
398_D 403_R 1.546 1.00
35_I 38_R 1.545 1.00
279_V 371_V 1.529 1.00
17_L 281_I 1.528 1.00
109_L 133_V 1.526 1.00
40_I 68_Q 1.512 1.00
30_V 281_I 1.508 1.00
19_R 23_E 1.503 1.00
281_I 371_V 1.479 1.00
33_A 37_R 1.477 1.00
240_D 243_H 1.472 1.00
140_W 221_A 1.47 1.00
334_E 360_A 1.469 1.00
411_I 415_L 1.455 1.00
174_A 185_L 1.449 0.99
172_P 175_L 1.434 0.99
396_L 405_I 1.429 0.99
171_L 211_Q 1.427 0.99
37_R 64_L 1.426 0.99
65_M 70_V 1.423 0.99
24_F 404_L 1.414 0.99
24_F 28_V 1.404 0.99
186_V 220_Q 1.402 0.99
77_L 81_E 1.398 0.99
81_E 411_I 1.397 0.99
190_M 208_M 1.394 0.99
26_C 299_D 1.387 0.99
85_A 412_E 1.382 0.99
124_V 172_P 1.379 0.99
23_E 402_A 1.376 0.99
113_S 137_H 1.376 0.99
36_I 65_M 1.363 0.99
298_V 370_L 1.361 0.99
282_T 300_A 1.358 0.99
294_H 335_T 1.356 0.99
83_A 97_I 1.35 0.99
121_A 139_V 1.342 0.99
20_L 402_A 1.341 0.99
39_Q 42_A 1.337 0.99
50_R 266_E 1.334 0.99
84_L 97_I 1.327 0.99
53_Q 72_V 1.319 0.99
407_R 419_L 1.316 0.99
395_V 402_A 1.316 0.99
337_V 361_L 1.313 0.99
171_L 215_F 1.312 0.99
89_N 96_D 1.3 0.99
77_L 108_T 1.298 0.99
335_T 361_L 1.286 0.98
15_E 32_D 1.279 0.98
103_V 297_L 1.278 0.98
252_R 256_A 1.27 0.98
22_A 283_Q 1.261 0.98
202_E 206_G 1.253 0.98
287_V 366_A 1.246 0.98
138_R 186_V 1.244 0.98
280_L 375_T 1.242 0.98
166_I 173_A 1.235 0.98
190_M 224_A 1.23 0.98
188_I 222_I 1.227 0.98
40_I 44_K 1.226 0.98
106_Q 110_E 1.218 0.98
167_W 170_D 1.215 0.98
121_A 130_L 1.21 0.98
385_N 391_L 1.206 0.97
132_Q 136_G 1.206 0.97
317_I 349_T 1.205 0.97
176_D 180_R 1.195 0.97
256_A 260_G 1.195 0.97
103_V 285_R 1.192 0.97
98_V 223_S 1.192 0.97
57_S 388_S 1.192 0.97
347_V 350_Q 1.175 0.97
293_R 351_Q 1.166 0.97
63_R 67_E 1.16 0.97
307_R 313_S 1.153 0.96
8_T 13_T 1.152 0.96
38_R 42_A 1.151 0.96
60_H 63_R 1.142 0.96
43_L 228_L 1.138 0.96
295_F 338_A 1.137 0.96
17_L 279_V 1.134 0.96
163_K 387_N 1.132 0.96
25_G 28_V 1.128 0.96
224_A 267_I 1.126 0.96
50_R 98_V 1.123 0.96
121_A 127_L 1.121 0.96
39_Q 272_F 1.119 0.96
40_I 273_L 1.116 0.95
230_V 374_D 1.11 0.95
254_Q 257_R 1.105 0.95
407_R 413_E 1.101 0.95
61_I 274_V 1.092 0.95
8_T 16_N 1.088 0.95
77_L 111_R 1.082 0.94
307_R 382_M 1.081 0.94
111_R 114_E 1.077 0.94
343_E 386_Y 1.07 0.94
139_V 183_L 1.068 0.94
113_S 130_L 1.068 0.94
191_H 269_P 1.067 0.94
21_P 369_Y 1.065 0.94
57_S 381_S 1.063 0.94
190_M 204_V 1.055 0.93
61_I 405_I 1.055 0.93
17_L 320_L 1.053 0.93
33_A 64_L 1.051 0.93
17_L 20_L 1.041 0.93
106_Q 133_V 1.037 0.93
124_V 128_D 1.033 0.92
199_A 203_Q 1.031 0.92
339_G 346_D 1.029 0.92
48_V 96_D 1.029 0.92
131_G 181_H 1.023 0.92
276_Q 374_D 1.021 0.92
118_P 264_K 1.019 0.92
90_P 97_I 1.015 0.91
336_V 350_Q 1.015 0.91
28_V 395_V 1.014 0.91
107_A 110_E 1.01 0.91
410_T 413_E 1.009 0.91
248_W 251_A 1.008 0.91
50_R 71_K 1.004 0.91
333_V 363_E 1 0.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1knwA10.98571000.205Contact Map0.699
2o0tA40.95711000.215Contact Map0.814
3vabA20.94761000.216Contact Map0.822
2qghA10.94521000.22Contact Map0.774
1twiA40.95241000.234Contact Map0.839
3n2bA40.94051000.236Contact Map0.863
2j66A10.93571000.239Contact Map0.774
3n29A20.90241000.264Contact Map0.62
3nzpA20.95241000.283Contact Map0.641
3nzqA20.9691000.284Contact Map0.643
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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