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OPENSEQ.org
DPO1 - DNA polymerase I
UniProt: P00582 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10746
Length: 928 (917)
Sequences: 1657
Seq/Len: 1.81
DPO1
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
217_E 220_K 6.342 1.00
576_E 593_K 5.853 1.00
808_Q 812_Q 4.315 1.00
818_L 851_T 3.995 1.00
161_G 164_E 3.948 1.00
637_K 642_D 3.843 1.00
31_S 283_E 3.744 1.00
524_N 528_N 3.616 1.00
725_T 729_E 3.575 1.00
539_R 864_D 3.564 1.00
240_K 244_Y 3.282 1.00
119_G 252_I 3.278 1.00
234_A 238_Q 3.27 1.00
569_K 626_V 3.198 1.00
126_E 146_T 3.188 1.00
866_W 870_E 3.159 1.00
558_E 688_R 3.084 1.00
194_P 239_N 3.037 1.00
785_Q 789_D 2.963 1.00
172_P 175_L 2.94 1.00
549_P 648_I 2.813 1.00
418_G 421_L 2.741 1.00
588_T 592_E 2.731 1.00
231_T 234_A 2.727 1.00
719_R 911_D 2.712 1.00
215_Y 244_Y 2.705 1.00
215_Y 240_K 2.689 1.00
876_M 886_F 2.682 1.00
700_V 922_E 2.663 1.00
239_N 242_V 2.652 1.00
800_E 804_R 2.604 1.00
571_H 577_E 2.584 1.00
207_G 220_K 2.528 1.00
212_D 247_Y 2.514 1.00
215_Y 218_P 2.469 1.00
271_A 274_E 2.454 1.00
589_I 593_K 2.434 1.00
570_A 580_L 2.415 1.00
30_N 283_E 2.411 1.00
886_F 896_V 2.407 1.00
901_H 905_E 2.406 1.00
529_I 819_D 2.393 1.00
526_F 531_M 2.39 1.00
22_Y 87_D 2.385 1.00
196_V 232_M 2.342 1.00
212_D 244_Y 2.322 1.00
874_V 892_D 2.32 1.00
97_A 281_K 2.308 1.00
261_T 264_Q 2.299 1.00
231_T 235_K 2.298 1.00
874_V 896_V 2.277 1.00
233_A 237_E 2.256 1.00
576_E 589_I 2.253 1.00
406_K 410_E 2.231 1.00
376_E 379_V 2.212 0.99
208_L 221_I 2.21 0.99
744_L 753_Q 2.204 0.99
73_L 248_Q 2.201 0.99
858_R 907_C 2.175 0.99
576_E 588_T 2.174 0.99
163_E 166_V 2.157 0.99
700_V 890_K 2.156 0.99
208_L 217_E 2.149 0.99
457_D 460_S 2.135 0.99
190_I 250_A 2.125 0.99
96_H 108_A 2.116 0.99
193_V 236_L 2.115 0.99
446_S 456_H 2.1 0.99
19_Y 23_H 2.098 0.99
556_S 642_D 2.097 0.99
163_E 167_N 2.084 0.99
546_K 696_P 2.079 0.99
517_Q 523_L 2.078 0.99
179_F 205_L 2.076 0.99
565_E 569_K 2.068 0.99
698_D 890_K 2.067 0.99
864_D 868_Q 2.066 0.99
649_N 652_T 2.06 0.99
563_L 634_A 2.059 0.99
819_D 908_T 2.058 0.99
886_F 900_I 2.056 0.99
213_T 216_A 2.049 0.99
799_L 803_E 2.024 0.99
276_L 288_T 2.018 0.99
410_E 433_I 2.011 0.99
359_D 367_N 2.009 0.99
440_F 526_F 2.001 0.99
730_G 915_L 1.984 0.99
562_R 565_E 1.981 0.99
807_A 811_E 1.973 0.99
419_Q 442_T 1.973 0.99
769_S 772_G 1.97 0.99
870_E 895_A 1.967 0.98
702_V 888_V 1.957 0.98
545_V 877_I 1.956 0.98
122_A 149_I 1.94 0.98
162_P 174_E 1.938 0.98
396_I 401_A 1.929 0.98
539_R 868_Q 1.916 0.98
898_K 902_Q 1.906 0.98
210_G 213_T 1.899 0.98
416_K 437_G 1.893 0.98
555_H 559_L 1.883 0.98
574_A 623_L 1.879 0.98
403_E 406_K 1.873 0.98
177_I 251_T 1.872 0.98
195_G 235_K 1.864 0.98
862_A 865_A 1.859 0.98
745_P 748_T 1.853 0.98
581_S 630_Y 1.851 0.98
412_E 436_R 1.834 0.97
100_K 106_L 1.83 0.97
332_T 495_G 1.824 0.97
123_R 127_K 1.818 0.97
803_E 806_R 1.813 0.97
97_A 100_K 1.812 0.97
562_R 629_E 1.808 0.97
67_K 72_E 1.807 0.97
573_I 626_V 1.804 0.97
335_D 338_T 1.804 0.97
866_W 903_L 1.791 0.97
552_L 692_A 1.777 0.97
816_E 822_R 1.775 0.97
529_I 858_R 1.754 0.96
8_P 131_P 1.746 0.96
699_Y 889_H 1.732 0.96
571_H 580_L 1.727 0.96
547_I 648_I 1.726 0.96
183_M 198_E 1.719 0.96
147_P 162_P 1.719 0.96
804_R 808_Q 1.718 0.96
444_L 662_A 1.718 0.96
203_A 207_G 1.714 0.96
828_I 839_A 1.714 0.96
525_V 529_I 1.712 0.96
340_K 404_L 1.711 0.96
833_G 836_R 1.694 0.95
162_P 166_V 1.694 0.95
429_A 542_R 1.677 0.95
347_E 411_D 1.665 0.95
660_H 672_T 1.659 0.94
203_A 223_G 1.659 0.94
123_R 254_T 1.643 0.94
208_L 220_K 1.636 0.94
179_F 198_E 1.635 0.94
213_T 217_E 1.628 0.94
867_L 896_V 1.622 0.94
922_E 926_Q 1.621 0.94
86_D 89_R 1.617 0.93
515_D 518_K 1.612 0.93
865_A 869_A 1.61 0.93
759_A 776_Q 1.606 0.93
221_I 236_L 1.603 0.93
73_L 245_L 1.602 0.93
702_V 893_V 1.592 0.93
166_V 172_P 1.586 0.93
564_A 567_E 1.585 0.93
447_Y 663_V 1.583 0.92
331_V 338_T 1.577 0.92
218_P 233_A 1.573 0.92
193_V 243_A 1.569 0.92
618_A 625_K 1.566 0.92
48_S 52_Q 1.562 0.92
896_V 900_I 1.561 0.92
739_A 745_P 1.551 0.91
523_L 527_E 1.551 0.91
902_Q 906_N 1.547 0.91
278_L 282_Y 1.547 0.91
873_R 892_D 1.544 0.91
889_H 892_D 1.543 0.91
411_D 414_A 1.535 0.91
355_D 501_D 1.531 0.91
562_R 685_E 1.53 0.91
893_V 897_A 1.526 0.91
440_F 445_E 1.518 0.90
810_K 836_R 1.517 0.90
32_A 281_K 1.511 0.90
362_D 365_S 1.51 0.90
371_L 383_I 1.506 0.90
373_F 383_I 1.495 0.89
126_E 148_N 1.495 0.89
735_R 746_L 1.492 0.89
218_P 237_E 1.49 0.89
858_R 862_A 1.488 0.89
426_G 538_S 1.487 0.89
721_K 725_T 1.471 0.88
336_E 400_R 1.467 0.88
893_V 920_S 1.464 0.88
594_Q 621_Y 1.464 0.88
568_K 577_E 1.461 0.88
833_G 837_A 1.459 0.88
473_F 477_A 1.456 0.88
862_A 903_L 1.454 0.88
39_M 282_Y 1.45 0.87
411_D 416_K 1.448 0.87
873_R 891_D 1.446 0.87
458_M 505_T 1.444 0.87
119_G 254_T 1.442 0.87
713_I 848_M 1.437 0.87
247_Y 251_T 1.431 0.86
463_E 469_K 1.431 0.86
511_K 515_D 1.427 0.86
223_G 233_A 1.421 0.86
568_K 572_E 1.421 0.86
827_D 839_A 1.415 0.86
329_N 379_V 1.405 0.85
342_W 381_A 1.402 0.85
814_Y 822_R 1.393 0.84
237_E 240_K 1.391 0.84
179_F 183_M 1.389 0.84
98_M 279_F 1.386 0.84
43_L 98_M 1.383 0.84
354_F 428_L 1.376 0.83
420_N 423_Y 1.376 0.83
486_F 494_A 1.365 0.83
702_V 897_A 1.353 0.82
863_V 903_L 1.347 0.82
377_P 510_L 1.346 0.81
560_T 637_K 1.342 0.81
171_V 202_Q 1.338 0.81
619_L 625_K 1.337 0.81
540_I 543_N 1.334 0.81
389_Y 393_P 1.331 0.80
702_V 900_I 1.33 0.80
888_V 893_V 1.328 0.80
740_E 794_R 1.327 0.80
704_A 916_V 1.327 0.80
737_T 761_N 1.325 0.80
874_V 900_I 1.324 0.80
919_G 927_A 1.323 0.80
25_F 37_G 1.323 0.80
215_Y 243_A 1.322 0.80
351_V 417_V 1.322 0.80
622_P 625_K 1.316 0.79
625_K 629_E 1.314 0.79
923_N 926_Q 1.314 0.79
874_V 889_H 1.305 0.79
659_Y 878_M 1.305 0.79
408_L 414_A 1.3 0.78
59_A 265_L 1.298 0.78
235_K 238_Q 1.294 0.78
719_R 724_L 1.29 0.77
802_M 806_R 1.287 0.77
462_A 470_T 1.285 0.77
67_K 71_D 1.279 0.77
863_V 886_F 1.273 0.76
752_E 756_S 1.273 0.76
136_T 141_M 1.272 0.76
445_E 526_F 1.27 0.76
569_K 572_E 1.267 0.76
207_G 222_A 1.266 0.76
274_E 277_G 1.266 0.76
84_M 89_R 1.264 0.75
198_E 202_Q 1.26 0.75
183_M 205_L 1.258 0.75
57_H 130_R 1.257 0.75
276_L 280_K 1.252 0.74
30_N 34_E 1.252 0.74
218_P 240_K 1.246 0.74
141_M 252_I 1.245 0.74
551_V 691_Q 1.244 0.74
21_A 45_M 1.239 0.73
35_P 90_A 1.237 0.73
578_F 589_I 1.233 0.73
345_K 379_V 1.227 0.72
741_V 759_A 1.225 0.72
802_M 844_I 1.222 0.72
618_A 624_P 1.22 0.72
424_D 501_D 1.215 0.71
556_S 637_K 1.209 0.71
419_Q 458_M 1.208 0.71
279_F 287_W 1.208 0.71
493_E 496_R 1.207 0.71
866_W 902_Q 1.206 0.70
897_A 901_H 1.202 0.70
208_L 218_P 1.201 0.70
472_T 475_E 1.201 0.70
118_I 134_I 1.201 0.70
97_A 274_E 1.198 0.70
171_V 175_L 1.198 0.70
888_V 896_V 1.195 0.69
126_E 149_I 1.193 0.69
370_G 382_Y 1.192 0.69
10_I 135_S 1.191 0.69
212_D 216_A 1.191 0.69
866_W 899_Q 1.19 0.69
739_A 744_L 1.189 0.69
536_V 861_I 1.189 0.69
740_E 787_Y 1.187 0.69
202_Q 206_Q 1.184 0.68
18_L 95_L 1.18 0.68
781_R 785_Q 1.176 0.68
360_S 423_Y 1.175 0.68
797_G 800_E 1.175 0.68
359_D 423_Y 1.174 0.68
145_V 151_L 1.172 0.67
235_K 239_N 1.172 0.67
112_V 256_V 1.164 0.67
66_G 71_D 1.162 0.66
724_L 728_A 1.162 0.66
181_A 250_A 1.159 0.66
101_A 278_L 1.158 0.66
35_P 87_D 1.157 0.66
490_A 493_E 1.157 0.66
855_I 914_L 1.156 0.66
568_K 571_H 1.156 0.66
458_M 470_T 1.155 0.66
34_E 94_P 1.155 0.66
51_M 290_D 1.152 0.65
218_P 223_G 1.149 0.65
713_I 717_L 1.149 0.65
731_K 736_A 1.148 0.65
691_Q 925_D 1.146 0.65
98_M 282_Y 1.146 0.65
770_A 785_Q 1.141 0.64
204_L 243_A 1.135 0.64
203_A 232_M 1.135 0.64
905_E 915_L 1.134 0.64
444_L 534_V 1.134 0.64
330_Y 503_D 1.132 0.63
195_G 204_L 1.131 0.63
356_T 368_L 1.129 0.63
406_K 433_I 1.128 0.63
194_P 242_V 1.126 0.63
214_L 221_I 1.125 0.63
906_N 909_R 1.125 0.63
38_A 95_L 1.124 0.63
717_L 801_Y 1.124 0.63
810_K 840_E 1.121 0.62
139_K 180_L 1.119 0.62
358_T 424_D 1.117 0.62
66_G 110_S 1.114 0.62
872_P 892_D 1.114 0.62
12_V 17_Y 1.114 0.62
204_L 240_K 1.113 0.61
215_Y 223_G 1.113 0.61
356_T 424_D 1.111 0.61
509_H 513_W 1.111 0.61
894_D 898_K 1.111 0.61
204_L 232_M 1.11 0.61
872_P 895_A 1.11 0.61
49_L 135_S 1.11 0.61
556_S 641_T 1.109 0.61
429_A 539_R 1.108 0.61
549_P 553_H 1.107 0.61
39_M 95_L 1.105 0.61
109_V 117_V 1.103 0.60
497_Y 501_D 1.102 0.60
355_D 424_D 1.101 0.60
855_I 908_T 1.099 0.60
22_Y 37_G 1.099 0.60
462_A 504_V 1.098 0.60
214_L 217_E 1.095 0.60
424_D 497_Y 1.094 0.59
343_I 404_L 1.091 0.59
866_W 869_A 1.091 0.59
621_Y 624_P 1.091 0.59
521_G 816_E 1.09 0.59
352_F 408_L 1.086 0.59
825_L 839_A 1.085 0.59
182_L 200_T 1.085 0.59
760_I 768_M 1.082 0.58
142_A 151_L 1.081 0.58
204_L 218_P 1.081 0.58
536_V 864_D 1.081 0.58
699_Y 875_R 1.08 0.58
165_V 171_V 1.08 0.58
771_F 781_R 1.08 0.58
243_A 246_S 1.08 0.58
385_V 401_A 1.078 0.58
838_A 842_A 1.078 0.58
126_E 132_V 1.076 0.58
450_N 464_R 1.076 0.58
721_K 797_G 1.076 0.58
786_K 789_D 1.076 0.58
224_L 234_A 1.074 0.57
772_G 776_Q 1.074 0.57
588_T 593_K 1.073 0.57
546_K 694_I 1.072 0.57
513_W 517_Q 1.072 0.57
870_E 903_L 1.07 0.57
569_K 573_I 1.069 0.57
570_A 626_V 1.068 0.57
696_P 699_Y 1.066 0.56
581_S 634_A 1.063 0.56
697_E 890_K 1.063 0.56
14_G 60_V 1.062 0.56
603_P 607_P 1.061 0.56
43_L 95_L 1.061 0.56
430_N 651_K 1.057 0.56
40_Y 286_R 1.051 0.55
756_S 783_E 1.051 0.55
358_T 501_D 1.051 0.55
476_I 489_I 1.05 0.55
120_T 256_V 1.047 0.54
399_E 403_E 1.044 0.54
736_A 740_E 1.043 0.54
273_E 277_G 1.041 0.54
355_D 358_T 1.039 0.54
543_N 875_R 1.039 0.54
474_E 479_K 1.036 0.53
240_K 243_A 1.036 0.53
223_G 234_A 1.034 0.53
842_A 846_A 1.031 0.53
196_V 204_L 1.03 0.53
421_L 534_V 1.029 0.53
356_T 501_D 1.025 0.52
867_L 874_V 1.024 0.52
477_A 483_Q 1.024 0.52
442_T 505_T 1.023 0.52
146_T 149_I 1.021 0.52
253_K 256_V 1.02 0.52
145_V 162_P 1.019 0.51
119_G 250_A 1.016 0.51
899_Q 903_L 1.014 0.51
334_L 338_T 1.013 0.51
589_I 623_L 1.012 0.51
286_R 289_A 1.009 0.50
215_Y 236_L 1.009 0.50
752_E 755_R 1.008 0.50
724_L 911_D 1.008 0.50
704_A 918_V 1.007 0.50
204_L 215_Y 1.007 0.50
248_Q 253_K 1.006 0.50
723_L 798_V 1.003 0.50
776_Q 787_Y 1.002 0.50
458_M 504_V 1.002 0.50
223_G 231_T 1.002 0.50
587_Q 607_P 1.001 0.49
357_E 424_D 1.001 0.49
425_R 538_S 1 0.49
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1bgxT10.88791000.274Contact Map0.516
2kfnA10.65191000.476Contact Map0.721
3pv8A20.63691000.492Contact Map0.756
4dfkA10.57761000.516Contact Map0.716
4bwjA10.57761000.517Contact Map0.718
1x9mA10.59591000.557Contact Map0.541
3ikmA20.71551000.76Contact Map0.313
3h7iA10.2921000.786Contact Map0.37
1exnA20.28231000.786Contact Map0.557
3zdbA10.26831000.787Contact Map0.658
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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