OPENSEQ.org
FtsL - FtsW

Genes: A B A+B
Length: 117 403 468
Sequences: 318 3305 80
Seq/Len: 2.72 8.2 0.17
MirrorTree (Pazo et al. 2001) 0.47
Download Alignment
We filter this alignment to remove positions that have > 75% gaps before running GREMLIN.

[Show HHblits results] - Maybe useful in deciding what regions to trim.

Δgene Ratio of paralogs Joined
A B Seq/Len
1 0.01 0.01 0.00
2 0.01 0.01 0.00
5 0.01 0.01 0.02
10 0.01 0.01 0.14
20 0.01 0.01 0.15
100 0.01 0.04 0.32
0.01 0.12 0.43
Paired alignment generation
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
Sequence A E-value:
Iterations:
Sequence B E-value:
Iterations:
Δgene MSA
Figure 1: The effect of Δgene on ratio of paralogs in the genome for each gene, and the number of sequences in the resulting joined alignment. Figure 2: Distribution of Δgene across all genomes. Figure 3: Current parameters. You can use the form to adjust the parameters and resubmit the job!

GREMLIN results (Scaled_score > 1):
Figure 4: The darker and larger the blue dots, the higher strength in coevolution.
Inter Residue pairs sorted by strength in coevolution signal:
i j Scaled Score Prob I_Prob
105_L 350_F 1.96 0.54 0.01
93_P 103_A 1.61 0.34 0.00
43_A 162_M 1.61 0.34 0.00
47_S 364_S 1.55 0.31 0.00
93_P 101_G 1.50 0.29 0.00
36_V 109_I 1.45 0.26 0.00
70_E 134_K 1.41 0.25 0.00
15_A 227_L 1.37 0.23 0.00
101_K 293_I 1.35 0.22 0.00
82_D 265_Y 1.34 0.22 0.00
41_F 350_F 1.29 0.20 0.00
80_I 351_I 1.27 0.19 0.00
18_P 281_A 1.25 0.18 0.00
108_K 101_G 1.24 0.18 0.00
93_P 314_F 1.23 0.18 0.00
47_S 22_G 1.19 0.16 0.00
23_I 25_L 1.18 0.16 0.00
54_S 53_F 1.17 0.16 0.00
49_S 265_Y 1.17 0.16 0.00
27_R 256_L 1.15 0.15 0.00
98_D 293_I 1.14 0.15 0.00
105_L 154_L 1.14 0.15 0.00
31_T 239_L 1.14 0.15 0.00
93_P 170_M 1.12 0.14 0.00
18_P 350_F 1.12 0.14 0.00
73_I 68_F 1.12 0.14 0.00
53_V 124_V 1.11 0.14 0.00
6_Y 182_C 1.11 0.14 0.00
2_S 278_A 1.09 0.14 0.00
73_I 326_I 1.08 0.13 0.00
105_L 8_S 1.08 0.13 0.00
39_V 314_F 1.07 0.13 0.00
67_Q 20_L 1.06 0.13 0.00
96_I 188_K 1.06 0.13 0.00
15_A 155_I 1.05 0.13 0.00
66_V 305_Y 1.05 0.13 0.00
95_R 268_L 1.05 0.13 0.00
44_A 298_F 1.04 0.12 0.00
31_T 317_L 1.04 0.12 0.00
82_D 101_G 1.04 0.12 0.00
56_A 146_V 1.04 0.12 0.00
6_Y 260_E 1.04 0.12 0.00
59_A 162_M 1.03 0.12 0.00
56_A 350_F 1.03 0.12 0.00
107_L 101_G 1.03 0.12 0.00
50_L 63_I 1.02 0.12 0.00
37_L 260_E 1.01 0.12 0.00
66_V 229_D 1.01 0.12 0.00
96_I 353_Y 1.00 0.11 0.00
41_F 254_F 1.00 0.11 0.00
32_L 91_I 1.00 0.11 0.00
28_A 306_I 0.99 0.11 0.00
7_Q 26_V 0.98 0.11 0.00
107_L 226_S 0.98 0.11 0.00
50_L 107_F 0.98 0.11 0.00
19_E 183_S 0.97 0.11 0.00
111_K 101_G 0.97 0.11 0.00
59_A 84_L 0.97 0.10 0.00
99_I 103_A 0.96 0.10 0.00
76_E 266_G 0.96 0.10 0.00
107_L 215_I 0.96 0.10 0.00
39_V 227_L 0.96 0.10 0.00
32_L 256_L 0.95 0.10 0.00
105_L 63_I 0.95 0.10 0.00
105_L 170_M 0.95 0.10 0.00
44_A 158_G 0.95 0.10 0.00
21_K 314_F 0.95 0.10 0.00
70_E 222_A 0.95 0.10 0.00
82_D 107_F 0.94 0.10 0.00
46_L 87_V 0.94 0.10 0.00
22_V 133_A 0.94 0.10 0.00
56_A 103_A 0.93 0.10 0.00
53_V 191_V 0.93 0.10 0.00
110_K 341_I 0.93 0.10 0.00
2_S 239_L 0.93 0.10 0.00
30_I 326_I 0.93 0.10 0.00
20_K 313_P 0.92 0.10 0.00
27_R 91_I 0.91 0.09 0.00
57_Y 365_M 0.91 0.09 0.00
86_S 326_I 0.91 0.09 0.00
96_I 55_L 0.90 0.09 0.00
84_E 221_L 0.90 0.09 0.00
19_E 190_L 0.89 0.09 0.00
41_F 103_A 0.89 0.09 0.00
75_S 183_S 0.89 0.09 0.00
96_I 300_V 0.89 0.09 0.00
105_L 53_F 0.89 0.09 0.00
26_K 334_L 0.89 0.09 0.00
9_E 147_A 0.89 0.09 0.00
60_Y 272_H 0.89 0.09 0.00
27_R 193_L 0.89 0.09 0.00
35_K 311_E 0.88 0.09 0.00
60_Y 124_V 0.88 0.09 0.00
55_K 124_V 0.88 0.09 0.00
9_E 229_D 0.88 0.09 0.00
23_I 91_I 0.88 0.09 0.00
67_Q 294_F 0.88 0.09 0.00
27_R 159_L 0.88 0.09 0.00
97_M 103_A 0.88 0.09 0.00
6_Y 33_M 0.88 0.09 0.00
30_I 59_G 0.88 0.09 0.00
22_V 22_G 0.88 0.09 0.00
115_I 103_A 0.87 0.09 0.00
21_K 32_S 0.87 0.09 0.00
97_M 101_G 0.87 0.09 0.00
91_S 310_C 0.87 0.09 0.00
72_Q 22_G 0.87 0.09 0.00
40_L 201_F 0.87 0.09 0.00
108_K 103_A 0.87 0.09 0.00
63_N 168_T 0.87 0.09 0.00
8_P 14_I 0.87 0.09 0.00
90_L 273_T 0.86 0.09 0.00
113_K 304_F 0.86 0.09 0.00
4_L 361_L 0.86 0.09 0.00
97_M 341_I 0.86 0.09 0.00
52_I 183_S 0.86 0.08 0.00
107_L 103_A 0.86 0.08 0.00
8_P 177_T 0.86 0.08 0.00
77_N 326_I 0.85 0.08 0.00
21_K 46_F 0.85 0.08 0.00
25_K 67_L 0.85 0.08 0.00
108_K 226_S 0.85 0.08 0.00
82_D 103_A 0.85 0.08 0.00
56_A 107_F 0.85 0.08 0.00
84_E 84_L 0.84 0.08 0.00
82_D 34_I 0.84 0.08 0.00
55_K 239_L 0.84 0.08 0.00
110_K 151_V 0.84 0.08 0.00
86_S 178_C 0.84 0.08 0.00
45_V 68_F 0.84 0.08 0.00
21_K 268_L 0.84 0.08 0.00
1_M 66_A 0.83 0.08 0.00
115_I 101_G 0.83 0.08 0.00
21_K 308_R 0.83 0.08 0.00
4_L 363_G 0.83 0.08 0.00
109_D 47_F 0.83 0.08 0.00
6_Y 291_F 0.82 0.08 0.00
19_E 300_V 0.82 0.08 0.00
56_A 335_G 0.82 0.08 0.00
9_E 151_V 0.81 0.08 0.00
94_Q 310_C 0.81 0.08 0.00
15_A 107_F 0.81 0.08 0.00
93_P 298_F 0.81 0.08 0.00
111_K 123_V 0.81 0.08 0.00
111_K 254_F 0.81 0.08 0.00
Figure 5: The i (protein A) and j (protein B) are positions as given in the query sequences.

Scaled Score = raw_score/average(raw_scores)
Prob = P(contact | scaled_score, seq/len)
I_Prob = P(contact | scaled_score, seq/len, top_inter_score)

ID Seq/Len Name Options I_Prob Status
8096 0.24 FtsL - FtsW Δgene:(1, 20) A:(1E-06, 8) B:(1E-06, 8) msa: HHblits (2015_06) 0.00 Done - Shared
8093 0.17 FtsL - FtsW Δgene:(1, 20) A:(1E-20, 8) B:(1E-20, 8) msa: HHblits (2015_06) 0.01 Done - Shared

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