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OPENSEQ.org
Vi-Vc
Genes: A B A+B
Length: 77 128 192
Sequences: 15224 9563 4292
Seq/Len: 197.71 74.71 22.35
MirrorTree (Pazo et al. 2001) 0.46
Download Alignment
We filter this alignment to remove positions that have > 75% gaps before running GREMLIN.

[Show HHblits results] - Maybe useful in deciding what regions to trim.
Δgene Ratio of paralogs Joined
A B Seq/Len
1 0.01 0.00 20.94
2 0.01 0.00 21.62
5 0.02 0.01 22.20
10 0.04 0.02 23.31
20 0.06 0.03 24.07
100 0.14 0.08 26.92
∞ 0.22 0.16 30.35
Paired alignment generation
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
Sequence A E-value:
Iterations:
Sequence B E-value:
Iterations:
Δgene MSA
Figure 1: The effect of Δgene on ratio of paralogs in the genome for each gene, and the number of sequences in the resulting joined alignment. Figure 2: Distribution of Δgene across all genomes. Figure 3: Current parameters. You can use the form to adjust the parameters and resubmit the job!
GREMLIN results (Scaled_score > 1):
Figure 4: The darker and larger the blue dots, the higher strength in coevolution. 		Inter Residue pairs sorted by strength in coevolution signal:
i j Scaled Score Prob I_Prob
47_D 8_Q 0.81 0.76 0.00
71_R 12_N 0.71 0.62 0.00
51_R 60_R 0.63 0.48 0.00
52_R 12_N 0.59 0.43 0.00
68_L 74_G 0.58 0.41 0.00
51_R 82_A 0.58 0.41 0.00
56_K 15_N 0.54 0.34 0.00
9_R 18_I 0.54 0.34 0.00
59_D 30_T 0.53 0.33 0.00
71_R 60_R 0.53 0.32 0.00
27_R 44_D 0.52 0.31 0.00
69_T 46_G 0.49 0.27 0.00
23_Q 68_R 0.48 0.26 0.00
45_T 77_L 0.47 0.25 0.00
17_L 6_M 0.47 0.24 0.00
55_E 9_V 0.47 0.24 0.00
37_Y 29_I 0.46 0.23 0.00
49_T 75_T 0.46 0.23 0.00
Figure 5: The i (protein A) and j (protein B) are positions as given in the query sequences.

Scaled Score = raw_score/average(raw_scores)
Prob = P(contact | scaled_score, seq/len)
I_Prob = P(contact | scaled_score, seq/len, top_inter_score)
ID Seq/Len Name Options I_Prob Status
5316 19.24 Vi-Vc Δgene:(1, 1) A:(1E-20, 2) B:(1E-20, 2) msa: Jackhmmer (2016_06b) 0.02 Done - Shared
5315 10.12 Vi-Vc Δgene:(1, 1) A:(1E-20, 4) B:(1E-40, 1) msa: HHblits (2015_06) 0.00 Done - Shared
5314 1.32 Vi-Vc Δgene:(1, 1) A:(1E-20, 4) B:(1E-40, 2) msa: Jackhmmer (2016_06b) 0.06 Done - Shared
5312 0.15 Vi-Vc Δgene:(1, 1) A:(1E-20, 2) B:(1E-40, 8) msa: Jackhmmer (2016_06b) Killed - Shared
5311 0 Vi-Vc Δgene:(1, 1) A:(1E-40, 8) B:(1E-40, 4) msa: HHblits (2015_06) Killed - Shared
5309 35.47 Vi-Vc Δgene:(1, 1) A:(1E-20, 4) B:(1E-20, 2) msa: Jackhmmer (2016_06b) 0.00 Done - Shared
5308 0.08 Vi-Vc Δgene:(1, 1) A:(1E-20, 1) B:(1E-40, 8) msa: Jackhmmer (2016_06b) Killed - Shared
5307 0 Vi-Vc Δgene:(1, 1) A:(1E-40, 4) B:(1E-40, 2) msa: HHblits (2015_06) Killed - Shared
5301 0 Vi-Vc Δgene:(1, 1) A:(1E-60, 8) B:(1E-60, 8) msa: HHblits (2015_06) Killed - Shared
5300 0.17 Vi-Vc Δgene:(1, 1) A:(1E-20, 4) B:(1E-40, 8) msa: Jackhmmer (2016_06b) Killed - Shared
5298 0 Vi-Vc Δgene:(1, 1) A:(1E-60, 4) B:(1E-60, 4) msa: HHblits (2015_06) Killed - Shared
5297 0.07 Vi-Vc Δgene:(1, 1) A:(1E-40, 8) B:(1E-40, 8) msa: Jackhmmer (2016_06b) Killed - Shared
5289 22.37 Vi-Vc Δgene:(1, 1) A:(1E-10, 4) B:(1E-40, 4) msa: HHblits (2015_06) 0.00 Done - Shared
5288 22.35 Vi-Vc Δgene:(1, 1) A:(1E-20, 4) B:(1E-40, 4) msa: HHblits (2015_06) 0.00 Done - Shared
5286 26.12 Vi-Vc Δgene:(1, 1) A:(1E-04, 8) B:(1E-04, 8) msa: Jackhmmer (2016_06b) 0.00 Done - Shared
5285 22.35 Vi-Vc Δgene:(1, 1) A:(1E-20, 8) B:(1E-40, 4) msa: HHblits (2015_06) 0.00 Done - Shared
5272 26.53 Vi-Vc Δgene:(1, 1) A:(1E-10, 8) B:(1E-20, 8) msa: Jackhmmer (2016_06b) 0.00 Done - Shared
5271 73.84 Vi-Vc Δgene:(1, 1) A:(1E-20, 8) B:(1E-20, 8) msa: HHblits (2015_06) 0.00 Done - Shared
5259 22.35 Vi-Vc Δgene:(1, 1) A:(1E-20, 8) B:(1E-40, 8) msa: HHblits (2015_06) 0.00 Done - Shared
5258 25.07 Vi-Vc Δgene:(1, 1) A:(1E-20, 8) B:(1E-20, 8) msa: Jackhmmer (2016_06b) 0.01 Done - Shared
5257 0.17 Vi-Vc Δgene:(1, 1) A:(1E-20, 8) B:(1E-40, 8) msa: Jackhmmer (2016_06b) Killed - Shared
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