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OPENSEQ.org
cIV_A_10_cI_J_2_Pdenitr
Genes: A B A+B
Length: 538 200 692
Sequences: 4448 6585 2751
Seq/Len: 8.27 32.92 3.98
MirrorTree (Pazo et al. 2001) 0.27
Download Alignment
We filter this alignment to remove positions that have > 75% gaps before running GREMLIN.

[Show Jackhmmer results] - Maybe useful in deciding what regions to trim.
Δgene Ratio of paralogs Joined
A B Seq/Len
1 0.01 0.00 0.02
2 0.01 0.00 0.06
5 0.02 0.01 0.26
10 0.02 0.01 1.92
20 0.03 0.01 2.05
100 0.04 0.03 2.36
∞ 0.08 0.06 3.73
Paired alignment generation
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
Sequence A E-value:
Iterations:
Sequence B E-value:
Iterations:
Δgene MSA
Figure 1: The effect of Δgene on ratio of paralogs in the genome for each gene, and the number of sequences in the resulting joined alignment. Figure 2: Distribution of Δgene across all genomes. Figure 3: Current parameters. You can use the form to adjust the parameters and resubmit the job!
GREMLIN results (Scaled_score > 1):
Figure 4: The darker and larger the blue dots, the higher strength in coevolution. 		Inter Residue pairs sorted by strength in coevolution signal:
i j Scaled Score Prob I_Prob
5_R 60_Y 1.17 0.87 0.14
438_I 21_V 1.15 0.85 0.13
26_V 161_A 1.07 0.80 0.10
531_P 33_L 0.95 0.67 0.07
305_V 62_G 0.89 0.60 0.06
442_L 48_G 0.89 0.60 0.06
99_F 158_M 0.85 0.55 0.05
213_W 81_E 0.82 0.51 0.05
501_V 150_A 0.81 0.50 0.04
5_R 74_M 0.81 0.49 0.04
159_A 156_V 0.81 0.49 0.04
438_I 92_L 0.79 0.47 0.04
485_L 21_V 0.79 0.47 0.04
200_K 25_N 0.79 0.46 0.04
378_S 5_A 0.79 0.46 0.04
384_R 155_L 0.78 0.46 0.04
376_V 66_V 0.78 0.46 0.04
278_I 161_A 0.77 0.44 0.04
351_I 105_G 0.76 0.43 0.04
131_A 43_L 0.74 0.40 0.03
410_A 41_A 0.74 0.40 0.03
22_T 62_G 0.74 0.40 0.03
46_V 41_A 0.73 0.39 0.03
375_V 43_L 0.73 0.39 0.03
378_S 161_A 0.73 0.39 0.03
360_A 160_G 0.73 0.39 0.03
466_F 47_Q 0.73 0.38 0.03
438_I 128_A 0.72 0.38 0.03
530_L 101_L 0.72 0.38 0.03
419_M 53_A 0.72 0.38 0.03
172_V 66_V 0.72 0.37 0.03
Figure 5: The i (protein A) and j (protein B) are positions as given in the query sequences.

Scaled Score = raw_score/average(raw_scores)
Prob = P(contact | scaled_score, seq/len)
I_Prob = P(contact | scaled_score, seq/len, top_inter_score)
ID Seq/Len Name Options I_Prob Status
3468 3.07 cIV_A_4_cI_J_6_Pdenitr Δgene:(1, ∞) A:(1E-04, 8) B:(1E-06, 8) msa: Jackhmmer (2015_06) 0.58 Done - Shared
3385 1.55 cIV_A_6_cI_J_10_Pdenitr Δgene:(1, ∞) A:(1E-06, 8) B:(1E-10, 8) msa: Jackhmmer (2015_06) 0.00 Done - Shared
3384 3.98 cIV_A_2_cI_J_2_Pdenitr Δgene:(1, ∞) A:(1E-02, 8) B:(1E-02, 8) msa: Jackhmmer (2015_06) 0.15 Done - Shared
3380 3.97 cIV_A_2_cI_J_2_Pdenitr Δgene:(1, ∞) A:(1E-02, 8) B:(1E-04, 8) msa: Jackhmmer (2015_06) 0.15 Done - Shared
3378 3.98 cIV_A_10_cI_J_2_Pdenitr Δgene:(1, ∞) A:(1E-10, 8) B:(1E-02, 8) msa: Jackhmmer (2015_06) 0.14 Done - Shared
3377 3.07 cIV_A_10_cI_J_6_Pdenitr Δgene:(1, ∞) A:(1E-10, 8) B:(1E-06, 8) msa: Jackhmmer (2015_06) 0.42 Done - Shared
3372 3.08 cIV_A_6_cI_J_6_Pdenitr Δgene:(1, ∞) A:(1E-06, 8) B:(1E-06, 8) msa: Jackhmmer (2015_06) 0.67 Done - Shared
3370 3.98 cIV_A_6_cI_J_4_Pdenitr Δgene:(1, ∞) A:(1E-10, 8) B:(1E-04, 8) msa: Jackhmmer (2015_06) 0.18 Done - Shared
3369 3.99 cIV_A_6_cI_J_4_Pdenitr Δgene:(1, ∞) A:(1E-06, 8) B:(1E-04, 8) msa: Jackhmmer (2015_06) 0.20 Done - Shared
3368 0.61 cIV_A_40_cI_J_40_Pdenitr Δgene:(1, ∞) A:(1E-40, 8) B:(1E-40, 8) msa: Jackhmmer (2015_06) 0.00 Done - Shared
3367 4 cIV_A_4_cI_J_4_Pdenitr Δgene:(1, ∞) A:(1E-04, 8) B:(1E-04, 8) msa: Jackhmmer (2015_06) 0.15 Done - Shared
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