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OPENSEQ.org
cIV_C_4_cI_A_20_Pdenitr
Genes: A B A+B
Length: 273 121 371
Sequences: 2888 4481 2401
Seq/Len: 10.58 37.03 6.47
MirrorTree (Pazo et al. 2001) 0.63
Download Alignment
We filter this alignment to remove positions that have > 75% gaps before running GREMLIN.

[Show Jackhmmer results] - Maybe useful in deciding what regions to trim.
Δgene Ratio of paralogs Joined
A B Seq/Len
1 0.00 0.00 4.30
2 0.00 0.00 4.48
5 0.00 0.00 4.83
10 0.00 0.00 5.12
20 0.00 0.00 5.27
100 0.00 0.01 5.34
∞ 0.01 0.02 6.09
Paired alignment generation
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
Sequence A E-value:
Iterations:
Sequence B E-value:
Iterations:
Δgene MSA
Figure 1: The effect of Δgene on ratio of paralogs in the genome for each gene, and the number of sequences in the resulting joined alignment. Figure 2: Distribution of Δgene across all genomes. Figure 3: Current parameters. You can use the form to adjust the parameters and resubmit the job!
GREMLIN results (Scaled_score > 1):
Figure 4: The darker and larger the blue dots, the higher strength in coevolution. 		Inter Residue pairs sorted by strength in coevolution signal:
i j Scaled Score Prob I_Prob
87_Q 115_K 1.69 1.00 0.95
22_I 80_L 1.34 0.98 0.83
196_A 32_I 1.18 0.94 0.71
80_P 87_F 1.13 0.93 0.66
13_P 84_A 1.11 0.92 0.65
6_H 66_V 1.09 0.91 0.62
177_V 16_G 1.08 0.90 0.61
26_V 117_A 1.07 0.90 0.60
13_P 78_A 1.05 0.89 0.58
18_F 78_A 1.04 0.88 0.57
21_A 79_F 0.95 0.81 0.46
107_A 62_R 0.95 0.81 0.46
39_T 27_L 0.94 0.79 0.44
138_W 62_R 0.93 0.79 0.44
54_G 78_A 0.90 0.75 0.40
10_I 45_Y 0.89 0.75 0.39
55_L 19_S 0.89 0.74 0.39
160_H 64_Y 0.89 0.74 0.39
22_I 89_S 0.88 0.74 0.38
99_M 66_V 0.88 0.74 0.38
180_I 20_A 0.88 0.73 0.38
121_P 84_A 0.88 0.73 0.38
183_V 11_I 0.87 0.72 0.36
54_G 68_I 0.86 0.71 0.35
146_L 62_R 0.86 0.70 0.35
139_H 61_V 0.85 0.69 0.34
121_P 99_M 0.84 0.69 0.33
158_A 111_Y 0.83 0.67 0.32
84_I 17_M 0.82 0.66 0.31
49_W 15_L 0.81 0.65 0.30
99_M 79_F 0.81 0.64 0.29
240_T 106_T 0.80 0.63 0.28
18_F 95_F 0.80 0.62 0.28
109_I 72_I 0.80 0.62 0.28
21_A 45_Y 0.79 0.62 0.28
56_V 23_I 0.78 0.60 0.27
13_P 101_F 0.78 0.60 0.27
183_V 15_L 0.77 0.59 0.26
33_A 69_L 0.77 0.58 0.25
143_I 104_V 0.77 0.58 0.25
190_A 67_S 0.77 0.58 0.25
205_Y 105_L 0.76 0.57 0.24
172_I 16_G 0.76 0.56 0.24
87_Q 113_W 0.76 0.56 0.24
125_G 62_R 0.76 0.56 0.24
203_T 72_I 0.76 0.56 0.24
138_W 78_A 0.75 0.55 0.23
242_K 55_A 0.74 0.55 0.23
153_V 62_R 0.74 0.54 0.23
240_T 75_L 0.74 0.54 0.22
10_I 80_L 0.74 0.54 0.22
33_A 119_E 0.74 0.54 0.22
229_V 18_A 0.74 0.53 0.22
73_G 88_A 0.73 0.53 0.22
203_T 92_D 0.73 0.53 0.22
221_I 30_A 0.73 0.53 0.22
75_T 64_Y 0.73 0.52 0.21
32_V 19_S 0.73 0.52 0.21
52_L 21_L 0.73 0.52 0.21
182_G 64_Y 0.72 0.51 0.21
98_V 65_L 0.72 0.51 0.21
150_L 81_F 0.72 0.51 0.21
31_A 37_P 0.72 0.50 0.20
8_Y 22_A 0.72 0.50 0.20
208_A 92_D 0.72 0.50 0.20
182_G 60_D 0.71 0.50 0.20
20_G 68_I 0.71 0.50 0.20
108_F 16_G 0.71 0.50 0.20
228_F 103_A 0.71 0.50 0.20
28_L 80_L 0.71 0.49 0.19
140_L 43_S 0.71 0.49 0.19
102_V 86_S 0.71 0.48 0.19
64_G 61_V 0.70 0.48 0.19
25_F 81_F 0.70 0.48 0.19
54_G 83_W 0.70 0.47 0.19
63_F 61_V 0.70 0.47 0.18
21_A 29_A 0.69 0.47 0.18
135_F 34_V 0.69 0.46 0.18
146_L 69_L 0.69 0.46 0.18
35_M 89_S 0.69 0.45 0.17
54_G 28_A 0.68 0.45 0.17
83_R 72_I 0.68 0.44 0.17
183_V 100_V 0.68 0.44 0.17
55_L 17_M 0.68 0.44 0.17
Figure 5: The i (protein A) and j (protein B) are positions as given in the query sequences.

Scaled Score = raw_score/average(raw_scores)
Prob = P(contact | scaled_score, seq/len)
I_Prob = P(contact | scaled_score, seq/len, top_inter_score)
ID Seq/Len Name Options I_Prob Status
3161 6.49 cIV_C_2_cI_A_20_Pdenitr Δgene:(1, ∞) A:(1E-02, 8) B:(1E-20, 8) msa: Jackhmmer (2015_06) 0.95 Done - Shared
3160 6.88 cIV_C_4_cI_A_10_Pdenitr Δgene:(1, ∞) A:(1E-04, 8) B:(1E-10, 8) msa: Jackhmmer (2015_06) 0.91 Done - Shared
3159 6.47 cIV_C_6_cI_A_20_Pdenitr Δgene:(1, ∞) A:(1E-06, 8) B:(1E-20, 8) msa: Jackhmmer (2015_06) 0.94 Done - Shared
3158 0.87 cIV_C_4_cI_A_40_Pdenitr Δgene:(1, ∞) A:(1E-04, 8) B:(1E-40, 8) msa: Jackhmmer (2015_06) 0.00 Done - Shared
3157 6.47 cIV_C_4_cI_A_20_Pdenitr Δgene:(1, ∞) A:(1E-04, 8) B:(1E-20, 8) msa: Jackhmmer (2015_06) 0.95 Done - Shared
3156 7.13 cIV_C_4_cI_A_6_Pdenitr Δgene:(1, ∞) A:(1E-04, 8) B:(1E-06, 8) msa: Jackhmmer (2015_06) 0.88 Done - Shared
3155 7.16 cIV_C_4_cI_A_4_Pdenitr Δgene:(1, ∞) A:(1E-04, 8) B:(1E-04, 8) msa: Jackhmmer (2015_06) 0.88 Done - Shared
3154 0.82 cIV_C_40_cI_A_40_Pdenitr Δgene:(1, ∞) A:(1E-40, 8) B:(1E-40, 8) msa: Jackhmmer (2015_06) 0.00 Done - Shared
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