May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org
cI_E_2_cIII_isp_4_Pdenitr
Genes: A B A+B
Length: 239 190 421
Sequences: 761 1692 245
Seq/Len: 3.18 8.91 0.58
MirrorTree (Pazo et al. 2001) 0.44
Download Alignment
We filter this alignment to remove positions that have > 75% gaps before running GREMLIN.

[Show Jackhmmer results] - Maybe useful in deciding what regions to trim.
Δgene Ratio of paralogs Joined
A B Seq/Len
1 0.00 0.00 0.00
2 0.00 0.00 0.00
5 0.00 0.01 0.00
10 0.01 0.01 0.00
20 0.01 0.01 0.00
100 0.01 0.01 0.04
∞ 0.04 0.05 0.57
Paired alignment generation
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
Sequence A E-value:
Iterations:
Sequence B E-value:
Iterations:
Δgene MSA
Figure 1: The effect of Δgene on ratio of paralogs in the genome for each gene, and the number of sequences in the resulting joined alignment. Figure 2: Distribution of Δgene across all genomes. Figure 3: Current parameters. You can use the form to adjust the parameters and resubmit the job!
GREMLIN results (Scaled_score > 1):
Figure 4: The darker and larger the blue dots, the higher strength in coevolution. 		Inter Residue pairs sorted by strength in coevolution signal:
i j Scaled Score Prob I_Prob
53_L 35_A 1.51 0.62 0.00
62_A 174_L 1.50 0.61 0.00
17_P 67_L 1.40 0.53 0.00
29_K 56_V 1.22 0.38 0.00
68_P 187_I 1.21 0.38 0.00
149_I 38_L 1.15 0.33 0.00
24_R 9_G 1.13 0.32 0.00
20_L 34_A 1.11 0.31 0.00
125_S 66_Q 1.11 0.31 0.00
66_G 131_V 1.07 0.28 0.00
68_P 52_A 1.04 0.26 0.00
158_T 87_Q 1.02 0.25 0.00
110_I 183_D 1.02 0.25 0.00
53_L 39_V 1.01 0.24 0.00
93_I 12_G 1.00 0.24 0.00
25_A 33_A 0.99 0.23 0.00
137_C 157_S 0.96 0.22 0.00
107_E 54_I 0.96 0.22 0.00
63_D 51_L 0.96 0.22 0.00
34_R 23_T 0.95 0.21 0.00
66_G 51_L 0.95 0.21 0.00
37_S 44_P 0.94 0.20 0.00
163_A 51_L 0.94 0.20 0.00
166_I 67_L 0.94 0.20 0.00
109_L 60_G 0.94 0.20 0.00
66_G 186_T 0.94 0.20 0.00
35_Q 65_T 0.94 0.20 0.00
193_T 131_V 0.92 0.19 0.00
123_A 123_G 0.92 0.19 0.00
24_R 26_A 0.91 0.19 0.00
47_Q 64_G 0.91 0.19 0.00
116_K 176_I 0.91 0.19 0.00
93_I 102_A 0.90 0.19 0.00
150_G 183_D 0.90 0.18 0.00
11_D 124_E 0.90 0.18 0.00
160_E 103_Q 0.89 0.18 0.00
135_V 23_T 0.89 0.18 0.00
164_A 31_A 0.89 0.18 0.00
108_D 78_I 0.89 0.18 0.00
158_T 33_A 0.88 0.17 0.00
161_K 162_S 0.87 0.17 0.00
18_A 62_E 0.87 0.17 0.00
70_I 19_L 0.86 0.17 0.00
34_R 15_R 0.86 0.17 0.00
66_G 88_A 0.85 0.16 0.00
58_I 32_G 0.85 0.16 0.00
167_D 129_I 0.85 0.16 0.00
56_P 19_L 0.84 0.15 0.00
130_F 124_E 0.83 0.15 0.00
160_E 28_T 0.83 0.15 0.00
69_Y 38_L 0.83 0.15 0.00
106_A 60_G 0.83 0.15 0.00
176_V 27_G 0.83 0.15 0.00
185_S 28_T 0.83 0.15 0.00
103_I 80_R 0.83 0.15 0.00
68_P 122_A 0.82 0.15 0.00
125_S 58_V 0.82 0.15 0.00
117_I 22_A 0.82 0.15 0.00
58_I 182_L 0.82 0.15 0.00
61_C 9_G 0.82 0.15 0.00
39_I 94_L 0.82 0.15 0.00
115_E 58_V 0.82 0.15 0.00
195_L 47_D 0.82 0.15 0.00
170_A 93_D 0.81 0.15 0.00
75_V 79_R 0.81 0.15 0.00
137_C 170_A 0.81 0.15 0.00
129_R 98_I 0.81 0.15 0.00
170_A 178_V 0.81 0.15 0.00
72_A 187_I 0.81 0.14 0.00
36_Q 128_M 0.81 0.14 0.00
72_A 54_I 0.81 0.14 0.00
77_T 41_Q 0.81 0.14 0.00
3_R 129_I 0.80 0.14 0.00
58_I 167_R 0.80 0.14 0.00
14_E 185_T 0.80 0.14 0.00
53_L 94_L 0.80 0.14 0.00
216_D 125_W 0.80 0.14 0.00
119_P 70_K 0.80 0.14 0.00
196_A 94_L 0.80 0.14 0.00
196_A 67_L 0.80 0.14 0.00
12_S 124_E 0.80 0.14 0.00
142_T 186_T 0.80 0.14 0.00
165_L 98_I 0.80 0.14 0.00
148_Q 138_V 0.80 0.14 0.00
120_E 61_V 0.80 0.14 0.00
72_A 122_A 0.79 0.14 0.00
Figure 5: The i (protein A) and j (protein B) are positions as given in the query sequences.

Scaled Score = raw_score/average(raw_scores)
Prob = P(contact | scaled_score, seq/len)
I_Prob = P(contact | scaled_score, seq/len, top_inter_score)
ID Seq/Len Name Options I_Prob Status
3023 0.57 cI_E_4_cIII_isp_2_Pdenitr Δgene:(1, ∞) A:(1E-04, 8) B:(1E-02, 8) msa: Jackhmmer (2015_06) 0.01 Done - Shared
3022 0.58 cI_E_2_cIII_isp_4_Pdenitr Δgene:(1, ∞) A:(1E-02, 8) B:(1E-04, 8) msa: Jackhmmer (2015_06) 0.00 Done - Shared
2799 0.56 cI_E_cIII_isp_Pdenitr Δgene:(1, ∞) A:(1E-04, 8) B:(1E-04, 8) msa: Jackhmmer (2015_06) 0.00 Done - Shared
Page generated in 0.3678 seconds.