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OPENSEQ.org
iscuiscs
Genes: A B A+B
Length: 128 404 509
Sequences: 1939 20044 1854
Seq/Len: 15.15 49.61 3.64
MirrorTree (Pazo et al. 2001) 0.82
Download Alignment
We filter this alignment to remove positions that have > 75% gaps before running GREMLIN.

[Show Jackhmmer results] - Maybe useful in deciding what regions to trim.
Δgene Ratio of paralogs Joined
A B Seq/Len
1 0.00 0.12 3.40
2 0.00 0.13 3.45
5 0.00 0.15 3.48
10 0.00 0.18 3.50
20 0.00 0.19 3.51
100 0.01 0.23 3.67
∞ 0.02 0.28 3.94
Paired alignment generation
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
Sequence A E-value:
Iterations:
Sequence B E-value:
Iterations:
Δgene MSA
Figure 1: The effect of Δgene on ratio of paralogs in the genome for each gene, and the number of sequences in the resulting joined alignment. Figure 2: Distribution of Δgene across all genomes. Figure 3: Current parameters. You can use the form to adjust the parameters and resubmit the job!
GREMLIN results (Scaled_score > 1):
Figure 4: The darker and larger the blue dots, the higher strength in coevolution. 		Inter Residue pairs sorted by strength in coevolution signal:
i j Scaled Score Prob I_Prob
100_P 36_P 0.77 0.41 0.00
58_F 210_P 0.67 0.30 0.00
36_A 334_E 0.63 0.25 0.00
87_A 135_K 0.62 0.25 0.00
47_V 25_Q 0.62 0.25 0.00
38_G 309_E 0.62 0.24 0.00
110_A 45_W 0.62 0.24 0.00
84_E 21_E 0.62 0.24 0.00
36_A 344_L 0.61 0.24 0.00
34_A 346_D 0.61 0.23 0.00
11_Y 290_N 0.60 0.23 0.00
34_A 105_K 0.60 0.23 0.00
77_V 287_V 0.60 0.22 0.00
38_G 311_E 0.60 0.22 0.00
56_A 273_L 0.59 0.22 0.00
51_G 196_K 0.59 0.22 0.00
118_I 358_G 0.57 0.20 0.00
73_V 20_A 0.57 0.20 0.00
46_K 364_E 0.56 0.19 0.00
65_S 360_F 0.55 0.18 0.00
116_A 170_C 0.55 0.18 0.00
Figure 5: The i (protein A) and j (protein B) are positions as given in the query sequences.

Scaled Score = raw_score/average(raw_scores)
Prob = P(contact | scaled_score, seq/len)
I_Prob = P(contact | scaled_score, seq/len, top_inter_score)
ID Seq/Len Name Options I_Prob Status
2042 3.61 IscUIscSmaxdist2 Δgene:(1, 2) A:(1E-20, 8) B:(1E-20, 8) msa: Jackhmmer (2015_03) 0.00 Done - Shared
1966 1.65 iscuiscs Δgene:(1, 2) A:(1E-20, 2) B:(1E-20, 2) msa: Jackhmmer (2015_03) 0.00 Done - Shared
1493 3.64 iscuiscs Δgene:(1, 5) A:(1E-20, 8) B:(1E-20, 8) msa: Jackhmmer (2015_03) 0.00 Done - Shared
1474 3.72 iscuiscs Δgene:(1, ∞) A:(1E-10, 4) B:(1E-20, 4) msa: Jackhmmer (2014_03) 0.00 Done - Shared
1460 2.84 iscuiscs Δgene:(1, 1) A:(1E-20, 4) B:(1E-20, 4) msa: Jackhmmer (2014_03) 0.00 Done - Shared
1448 3.45 iscuiscs Δgene:(1, 20) A:(1E-06, 8) B:(1E-06, 8) msa: Jackhmmer (2014_03) 0.00 Done - Shared
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