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OPENSEQ.org
4HEA_H - 4HEA_N
UniProt: Q60019 - Q56229 Query Sequences:

 Download Alignment
We filter this alignment to remove positions that have > 75% gaps before running GREMLIN.
Length: 792
Sequences: 3573
Seq/Len: 4.87
I_Prob: 0.15
GREMLIN Results (Scaled_score > 1):

Legend: The darker and larger the blue dots, the higher strength in coevolution. Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on HHsearch results which uses the overall probability and per-site alignment confidence. Inter-chain contacts in the pdb are in shades of red.
4heaHQ:NV:MU:LTContact Map
4he8CH:IN:GM:FLContact Map


 Residue pairs sorted by strength in coevolution signal:
i j Scaled Score I_Prob
232_Y 265_H 1.15 0.15
285_F 96_H 1.09 0.12
265_G 260_Y 1.05 0.11
261_T 147_F 1.01 0.10
72_I 150_G 0.98 0.09
309_G 194_F 0.98 0.09
83_V 221_A 0.97 0.09
199_A 312_L 0.96 0.08
122_I 211_M 0.94 0.08
85_A 223_L 0.94 0.08
181_N 299_L 0.93 0.07
182_L 331_L 0.93 0.07
179_S 237_V 0.92 0.07
115_V 192_F 0.92 0.07
183_N 203_S 0.92 0.07
266_G 366_V 0.91 0.07
14_A 286_L 0.90 0.07
125_L 242_V 0.88 0.06
85_A 254_A 0.88 0.06
214_A 199_V 0.88 0.06
170_L 368_S 0.88 0.06
195_L 325_A 0.87 0.06
203_F 258_L 0.86 0.06
176_L 322_L 0.85 0.06
322_L 175_A 0.85 0.06
260_P 96_H 0.85 0.06
322_L 327_L 0.84 0.05
149_L 331_L 0.83 0.05
304_Q 253_E 0.83 0.05
132_A 138_L 0.83 0.05
173_P 298_V 0.83 0.05
183_N 300_S 0.83 0.05
261_T 157_A 0.82 0.05
220_D 112_E 0.82 0.05
116_I 151_A 0.82 0.05
128_V 360_V 0.82 0.05
238_S 203_S 0.82 0.05
132_A 236_L 0.82 0.05
142_A 184_G 0.81 0.05
63_A 115_S 0.81 0.05
85_A 194_F 0.81 0.05
243_L 143_A 0.81 0.05
183_N 327_L 0.81 0.05
180_L 220_F 0.81 0.05
95_L 123_T 0.80 0.05
100_I 367_T 0.80 0.05
100_I 192_F 0.80 0.05
27_A 330_M 0.80 0.05
173_P 358_W 0.80 0.05
69_K 112_E 0.80 0.05
26_T 99_A 0.80 0.05
124_Y 192_F 0.80 0.05
264_L 326_F 0.80 0.05
282_K 259_A 0.79 0.04
72_I 189_L 0.79 0.04
145_S 338_P 0.78 0.04
268_T 224_L 0.78 0.04
175_L 117_P 0.78 0.04
132_A 368_S 0.78 0.04
316_L 93_L 0.78 0.04
170_L 350_A 0.77 0.04
237_S 94_G 0.77 0.04
98_G 97_L 0.77 0.04
243_L 141_A 0.77 0.04
228_L 149_Y 0.77 0.04
250_I 221_A 0.77 0.04
202_A 94_G 0.76 0.04
100_I 286_L 0.75 0.04
321_F 220_F 0.75 0.04
179_S 139_L 0.75 0.04
224_A 103_H 0.75 0.04
96_A 327_L 0.75 0.04
276_Y 235_L 0.74 0.04
95_L 319_D 0.74 0.04
44_V 331_L 0.74 0.04
85_A 230_P 0.74 0.04
208_I 175_A 0.74 0.04
128_V 366_V 0.74 0.04
238_S 379_G 0.73 0.04
266_G 294_L 0.73 0.04
185_I 256_R 0.73 0.04
247_A 213_T 0.73 0.04
196_F 286_L 0.73 0.04
177_V 311_A 0.73 0.04
187_N 289_V 0.73 0.04
40_A 247_A 0.73 0.04
79_R 295_A 0.73 0.04
96_A 275_T 0.72 0.04
283_I 232_A 0.72 0.04
185_I 373_Y 0.72 0.03
318_L 339_L 0.72 0.03
180_L 221_A 0.72 0.03
266_G 274_Y 0.72 0.03
167_G 192_F 0.72 0.03
297_W 264_A 0.72 0.03
283_I 129_G 0.72 0.03
180_L 367_T 0.72 0.03
285_F 233_L 0.72 0.03
238_S 121_L 0.72 0.03
87_L 290_L 0.71 0.03
221_L 198_D 0.71 0.03
63_A 144_A 0.71 0.03
80_F 258_L 0.71 0.03
117_N 189_L 0.71 0.03
196_F 358_W 0.71 0.03
136_I 376_L 0.71 0.03
316_L 300_S 0.71 0.03
280_F 264_A 0.71 0.03
265_G 218_A 0.71 0.03
180_L 275_T 0.71 0.03
131_L 368_S 0.71 0.03
309_G 200_Y 0.70 0.03
101_P 135_K 0.70 0.03
287_L 324_L 0.70 0.03
293_I 238_A 0.70 0.03
289_F 322_L 0.70 0.03
38_L 150_G 0.70 0.03
46_M 250_A 0.70 0.03
246_M 102_R 0.69 0.03
165_G 204_P 0.69 0.03
322_L 234_A 0.69 0.03
188_W 226_V 0.69 0.03
281_L 284_Y 0.69 0.03
283_I 226_V 0.69 0.03
316_L 365_L 0.69 0.03
254_T 271_L 0.69 0.03
260_P 241_V 0.69 0.03
266_G 212_A 0.69 0.03
94_L 249_L 0.69 0.03
246_M 149_Y 0.69 0.03
66_S 257_L 0.69 0.03
206_Y 265_H 0.69 0.03
228_L 220_F 0.69 0.03
174_V 280_A 0.69 0.03
132_A 212_A 0.68 0.03
Legend: The i (protein A) and j (protein B) are positions as given in the UniProt sequences. The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction.

Scaled Score = raw_score/average(raw_scores)
I_Prob = P(contact | scaled_score, seq/len, top_inter_score)

Text file of predictions (includes both intra and inter preds)
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